Ingo Bechmann
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View article: Diet-Driven Microglial Activation: Region-Specific Neuroinflammation in the Mouse Brain
Diet-Driven Microglial Activation: Region-Specific Neuroinflammation in the Mouse Brain Open
Background: High-fat diet (HFD) consumption is commonly linked to low-grade brain inflammation and increased risk of neurodegeneration. However, in our previous research, HFD exposure for up to 24 weeks did not increase pro-inflammatory cy…
View article: Exploring the Impact of a High‐Fat Diet on Brain Homeostasis: A Comprehensive Analysis of the Absence of Inflammation
Exploring the Impact of a High‐Fat Diet on Brain Homeostasis: A Comprehensive Analysis of the Absence of Inflammation Open
Excessive fat consumption increases the risk of Alzheimer's disease (AD), potentially through diet‐induced neuroinflammation. Microglia, the brain's immune cells, are affected by obesity and diet. Phytosterols (PS), plant‐derived cholester…
View article: Personalized drug stratification using endoscopic samples to assess ex vivo gastric cancer tissue susceptibility to chemotherapy and immune checkpoint inhibitors
Personalized drug stratification using endoscopic samples to assess ex vivo gastric cancer tissue susceptibility to chemotherapy and immune checkpoint inhibitors Open
Customizing drug treatments based on individual tumor susceptibility and patient-specific factors is a complex task, highlighting the need for better predictive models tailored to each patient. Preserving tumor architecture is one strategy…
View article: Intranasal Application of Peptides Modulating the Neuropeptide Y System
Intranasal Application of Peptides Modulating the Neuropeptide Y System Open
The neuropeptide Y multireceptor-multiligand system plays an important role in multiple physiological processes. Targeting the neuropeptide Y1 (Y1R) and Y2 (Y2R) receptors has gained interest in treating weight and mental disorders. Nose-t…
View article: Noncanonical microglial IL-1β maturation in chronic kidney disease
Noncanonical microglial IL-1β maturation in chronic kidney disease Open
Background Organ transplantation reverses cognitive impairment in chronic kidney disease (CKD), indicating that cognitive impairment driven by CKD is therapeutically amendable. We recently demonstrated that impaired cognition in CKD is lin…
View article: Peptidoglycan accumulates in distinct brain regions and cell types over lifetime but is absent in newborns
Peptidoglycan accumulates in distinct brain regions and cell types over lifetime but is absent in newborns Open
Peptidoglycan (PGN) is a large complex polymer critical to structure and function of all bacterial species. Intact PGN and its fragments are inflammatory, contributing to infectious and autoimmune disease. Recent studies show that PGN phys…
View article: Chronic kidney disease leads to microglial potassium efflux and inflammasome activation in the brain
Chronic kidney disease leads to microglial potassium efflux and inflammasome activation in the brain Open
Cognitive impairment is common in extracerebral diseases such as chronic kidney disease (CKD). Kidney transplantation reverses cognitive impairment, indicating that cognitive impairment driven by CKD is therapeutically amendable. However, …
View article: Melanocortin-4 Receptor PLC Activation Is Modulated by an Interaction with the Monocarboxylate Transporter 8
Melanocortin-4 Receptor PLC Activation Is Modulated by an Interaction with the Monocarboxylate Transporter 8 Open
The melanocortin-4 receptor (MC4R) is a key player in the hypothalamic leptin–melanocortin pathway that regulates satiety and hunger. MC4R belongs to the G protein-coupled receptors (GPCRs), which are known to form heterodimers with other …
View article: Myeloid cell-derived interleukin-6 induces vascular dysfunction and vascular and systemic inflammation
Myeloid cell-derived interleukin-6 induces vascular dysfunction and vascular and systemic inflammation Open
Aims The cytokine interleukin-6 (IL-6) plays a central role in the inflammation cascade as well as cardiovascular disease progression. Since myeloid cells are a primary source of IL-6 formation, we aimed to generate a mouse model to study …
View article: Chronic kidney disease leads to microglial potassium efflux and inflammasome activation in the brain
Chronic kidney disease leads to microglial potassium efflux and inflammasome activation in the brain Open
Cognitive impairment is common in peripheral diseases such as chronic kidney disease (CKD). Kidney transplantation reverses cognitive impairment, indicating that cognitive impairment driven by CKD is therapeutically amendable. Yet, we lack…
View article: Interleukin-36γ is causative for liver damage upon infection with Rift Valley fever virus in type I interferon receptor-deficient mice
Interleukin-36γ is causative for liver damage upon infection with Rift Valley fever virus in type I interferon receptor-deficient mice Open
Type I interferons (IFN) are pro-inflammatory cytokines which can also exert anti-inflammatory effects via the regulation of interleukin (IL)-1 family members. Several studies showed that interferon receptor (IFNAR)-deficient mice develop …
View article: SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19
SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19 Open
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has been associated mainly with a range of neurological symptoms, including brain fog and brain tissue loss, raising conc…
View article: Characterization of Non-Cholesterol Sterols in Microglia Cell Membranes Using Targeted Mass Spectrometry
Characterization of Non-Cholesterol Sterols in Microglia Cell Membranes Using Targeted Mass Spectrometry Open
Background: Non-cholesterol sterols, as well as plant sterols, cross the blood–brain barrier and, thus, can be incorporated into cell membranes, affecting the cell’s inflammatory response. The aim of our work was to develop an analytical p…
View article: Noncanonical Il-1β maturation in microglia impairs cognition in chronic kidney disease via neuronal IL-1R signaling
Noncanonical Il-1β maturation in microglia impairs cognition in chronic kidney disease via neuronal IL-1R signaling Open
While cognitive impairment is common in peripheral diseases such as chronic kidney disease (CKD), mechanistic insights and effective therapies are lacking 1,2 . Organ substitution reverses cognitive impairment, indicating that cognitive im…
View article: <scp>IGF1R</scp> expression by adult oligodendrocytes is not required in the steady‐state but supports neuroinflammation
<span>IGF1R</span> expression by adult oligodendrocytes is not required in the steady‐state but supports neuroinflammation Open
In the central nervous system (CNS), insulin‐like growth factor 1 (IGF‐1) regulates myelination by oligodendrocyte (ODC) precursor cells and shows anti‐apoptotic properties in neuronal cells in different in vitro and in vivo systems. Previ…
View article: Is microglial dystrophy a form of cellular senescence? An analysis of senescence markers in the aged human brain
Is microglial dystrophy a form of cellular senescence? An analysis of senescence markers in the aged human brain Open
Aging can cause morphological transformation in human microglia indicative of cell senescence, termed microglial dystrophy. However, cellular senescence is characterized by additional changes, such as an irregular cell cycle arrest, and a …
View article: Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in neuroinflammation
Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in neuroinflammation Open
SUMMARY The meninges of the brain are an important component of neuroinflammatory response. Diverse immune cells move from the calvaria marrow into the dura mater via recently discovered skull-meninges connections (SMCs). However, how the …
View article: RNA sequencing of glioblastoma tissue slice cultures reveals the effects of treatment at the transcriptional level
RNA sequencing of glioblastoma tissue slice cultures reveals the effects of treatment at the transcriptional level Open
One of the major challenges in cancer research is finding models that closely resemble tumors within patients. Human tissue slice cultures are a promising approach to provide a model of the patient's tumor biology ex vivo . Recently, it wa…
View article: Plant Sterol-Poor Diet Is Associated with Pro-Inflammatory Lipid Mediators in the Murine Brain
Plant Sterol-Poor Diet Is Associated with Pro-Inflammatory Lipid Mediators in the Murine Brain Open
Plant sterols (PSs) cannot be synthesized in mammals and are exclusively diet-derived. PSs cross the blood-brain barrier and may have anti-neuroinflammatory effects. Obesity is linked to lower intestinal uptake and blood levels of PSs, but…
View article: Long-term diet-induced obesity does not lead to learning and memory impairment in adult mice
Long-term diet-induced obesity does not lead to learning and memory impairment in adult mice Open
Obesity arising from excessive dietary fat intake is a risk factor for cognitive decline, dementia and neurodegenerative diseases, including Alzheimer’s disease. Here, we studied the effect of long-term high-fat diet (HFD) (24 weeks) and r…