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View article: Visualizing the Invisible: Dual Click Imaging of Ruthenium-Based Photoactivated Chemotherapy Agents and Their DNA Synthesis Inhibition in Fixed Cancer Cells
Visualizing the Invisible: Dual Click Imaging of Ruthenium-Based Photoactivated Chemotherapy Agents and Their DNA Synthesis Inhibition in Fixed Cancer Cells Open
Like many drugs, ruthenium-based photoactivated chemotherapy (PACT) complexes are hard to follow in cells due to their absence of emissive properties. Here, two alkyne-functionalized Ru-based PACT compounds with the formula [Ru(HCC-tpy)(N̂N…
View article: Redox-Active Quinazolinone Thioamide Ag(I) Complexes with Potent Antibacterial Activity: Mechanistic Insights and Hydrogel-Enhanced Efficacy
Redox-Active Quinazolinone Thioamide Ag(I) Complexes with Potent Antibacterial Activity: Mechanistic Insights and Hydrogel-Enhanced Efficacy Open
The antibacterial properties of Ag(I) coordination compounds are well documented; however, their effectiveness is highly dependent on the choice of appropriate ligands, and it is frequently hindered by their low water solubility and limite…
View article: Group 10 and Group 11 Metal Complexes of a Thermally Stable N‐Heterocyclic Carbene with a 1,1′‐Ferrocenylene Backbone
Group 10 and Group 11 Metal Complexes of a Thermally Stable N‐Heterocyclic Carbene with a 1,1′‐Ferrocenylene Backbone Open
The reaction of the stable ferrocene‐based N‐heterocyclic carbene (NHC) fc[N(CH 2 Mes)] 2 C ( A ; fc = 1,1 ′ ‐ferrocenylene, Mes = mesityl) with CuX (1 equivalent; X = Cl, Br, I, Mes) afforded [CuX( A )]. [AgCl( A )] is synthesized analogo…
View article: Potent inhibition of SARS-CoV-2 proteases PLpro and 3CLpro by selected gold(III)-dithiocarbamato complexes showing strong and selective antiviral activity against HCoV-OC43
Potent inhibition of SARS-CoV-2 proteases PLpro and 3CLpro by selected gold(III)-dithiocarbamato complexes showing strong and selective antiviral activity against HCoV-OC43 Open
Selected gold(III)-dithiocarbamato complexes were identified as potent inhibitors of two critical enzymes involved in the SARS-CoV-2 replication cycle, the papain-line protease (PLpro) and the 3-chymotrypsin-like protease (3CLpro), showing…
View article: Gold‐Dithiocarbamato Glycoconjugates as Potential Anticancer Agents: Design, Physico‐Chemical Characterization, and <i>In Vitro</i> Biological Activity
Gold‐Dithiocarbamato Glycoconjugates as Potential Anticancer Agents: Design, Physico‐Chemical Characterization, and <i>In Vitro</i> Biological Activity Open
To develop new metal‐based glycoconjugates as potential anticancer agents, three gold(III)‐dithiocarbamato glycoconjugates of the type [Au III Br 2 (SSC‐Inp‐GlcN)] ( Au3‐5 ), their gold(I)‐phosphine counterparts [Au I (SSC‐Inp‐GlcN)(PPh 3 …
View article: Silver N‐Heterocyclic Biscarbene Complexes: Potent Inhibitors of Thioredoxin Reductase with Anticancer Activity in Vitro and in Vivo
Silver N‐Heterocyclic Biscarbene Complexes: Potent Inhibitors of Thioredoxin Reductase with Anticancer Activity in Vitro and in Vivo Open
Silver N ‐heterocyclic carbene (NHC) complexes are known to form biscarbene species from monocarbene analogs in protic polar solvents. However, the effect of the respective species of silver NHC complexes on their biological activity again…
View article: Synthesis and Biological Evaluation of a New Biphenyl-Based Organogold(III) Complex with In Vitro and In Vivo Anticancer Activity
Synthesis and Biological Evaluation of a New Biphenyl-Based Organogold(III) Complex with In Vitro and In Vivo Anticancer Activity Open
Despite recent advances in cancer treatment, there is still a need for novel compounds with antineoplastic activity. Among 11 biphenyl-based organogold(III) N-heterocyclic carbene (NHC) (BGC) complexes of general formula [(C^C)Au(NHC-pyr)X…
View article: A new generation of N-heterocyclic carbene (NHC) gold–selenolato complexes as potent anticancer agents: distinct synthetic routes and evaluation in 2D and 3D cancer models
A new generation of N-heterocyclic carbene (NHC) gold–selenolato complexes as potent anticancer agents: distinct synthetic routes and evaluation in 2D and 3D cancer models Open
Two distinct synthetic pathways are disclosed that lead to new gold–selenolato complexes, stabilized by N-heterocyclic carbenes (NHCs).
View article: Modulation of the mechanism of action of antibacterial silver N-heterocyclic carbene complexes by variation of the halide ligand
Modulation of the mechanism of action of antibacterial silver N-heterocyclic carbene complexes by variation of the halide ligand Open
The halide ligand of silver N-heterocyclic carbene complexes governs their antibacterial activity and mechanism of action.
View article: Antiproliferative effects, mechanism of action and tumor reduction studies in a lung cancer xenograft mouse model of an organometallic gold(<scp>i</scp>) alkynyl complex
Antiproliferative effects, mechanism of action and tumor reduction studies in a lung cancer xenograft mouse model of an organometallic gold(<span>i</span>) alkynyl complex Open
An organometallic anticancer drug candidate with a mechanism related to TrxR inhibition and mitochondrial respiration inhibition shows efficient in vivo antitumor efficacy.
View article: An organometallic hybrid antibiotic of metronidazole with a Gold(I) N-Heterocyclic Carbene overcomes metronidazole resistance in Clostridioides difficile
An organometallic hybrid antibiotic of metronidazole with a Gold(I) N-Heterocyclic Carbene overcomes metronidazole resistance in Clostridioides difficile Open
Antimicrobial resistance (AMR) has been emerging as a major global health threat and calls for the development of novel drug candidates. Metal complexes have been demonstrating high efficiency as antibacterial agents that differ substantia…
View article: Silver Organometallics that are Highly Potent Thioredoxin and Glutathione Reductase Inhibitors: Exploring the Correlations of Solution Chemistry with the Strong Antibacterial Effects
Silver Organometallics that are Highly Potent Thioredoxin and Glutathione Reductase Inhibitors: Exploring the Correlations of Solution Chemistry with the Strong Antibacterial Effects Open
The antibacterial activity of silver species is well-established; however, their mechanism of action has not been adequately explored. Furthermore, issues of low-molecular silver compounds with cytotoxicity, stability, and solubility hampe…
View article: Paraptotic Cell Death as an Unprecedented Mode of Action Observed for New Bipyridine-Silver(I) Compounds Bearing Phosphane Coligands
Paraptotic Cell Death as an Unprecedented Mode of Action Observed for New Bipyridine-Silver(I) Compounds Bearing Phosphane Coligands Open
In this work, we investigated the anticancer activity of several novel silver(I) 2,2'-bipyridine complexes containing either triphenylphosphane (PPh3) or 1,2-bis(diphenylphosphino)ethane (dppe) ligands. All compounds were characterized by …
View article: CCDC 2310641: Experimental Crystal Structure Determination
CCDC 2310641: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2310644: Experimental Crystal Structure Determination
CCDC 2310644: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2310643: Experimental Crystal Structure Determination
CCDC 2310643: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2310642: Experimental Crystal Structure Determination
CCDC 2310642: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2310639: Experimental Crystal Structure Determination
CCDC 2310639: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2310640: Experimental Crystal Structure Determination
CCDC 2310640: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2310645: Experimental Crystal Structure Determination
CCDC 2310645: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: A dual approach to cancer treatment: gold(<scp>i</scp>) terpyridine derivatives as DNA binders and inhibitors of mammalian thioredoxin reductase
A dual approach to cancer treatment: gold(<span>i</span>) terpyridine derivatives as DNA binders and inhibitors of mammalian thioredoxin reductase Open
Gold( i ) terpyridine derivatives exhibiting exceptional cytotoxic activity against critical cancer types are elucidated. Significantly, these compounds demonstrate dual functionality by interacting with DNA and inhibiting TrxR.
View article: Synthesis of N-heterocyclic carbene gold(<scp>i</scp>) complexes from the marine betaine 1,3-dimethylimidazolium-4-carboxylate
Synthesis of N-heterocyclic carbene gold(<span>i</span>) complexes from the marine betaine 1,3-dimethylimidazolium-4-carboxylate Open
The marine natural product norzooanemonin has been used to prepare a series of carboxyl-functionalized N-heterocyclic carbene (NHC) gold( i ) complexes with cytotoxic and antibacterial activity.
View article: Gold(<scp>i</scp>) and gold(<scp>iii</scp>) carbene complexes from the marine betaine norzooanemonin: inhibition of thioredoxin reductase, antiproliferative and antimicrobial activity
Gold(<span>i</span>) and gold(<span>iii</span>) carbene complexes from the marine betaine norzooanemonin: inhibition of thioredoxin reductase, antiproliferative and antimicrobial activity Open
Gold( i / iii ) complexes based on the marine natural betaine norzooanemonin display excellent antibacterial and cyctotoxic activity based on the nature of carboxylate functionalization.
View article: Potent Anticancer Activity of a Dinuclear Gold(I) bis‐<i>N</i>‐Heterocyclic Imine Complex Related to Thioredoxin Reductase Inhibition <i>in Vitro</i>
Potent Anticancer Activity of a Dinuclear Gold(I) bis‐<i>N</i>‐Heterocyclic Imine Complex Related to Thioredoxin Reductase Inhibition <i>in Vitro</i> Open
A dinuclear gold(I) complex featuring a strongly donating bis‐ N ‐heterocyclic imine ligand was synthesised and characterised by different methods, including single crystal X‐ray diffraction (SC‐XRD) analysis. The compound has been tested …
View article: Multitarget Thiol-Activated Tetrapyridyl Gold(III) Complexes for Hypoxic Cancer Therapy
Multitarget Thiol-Activated Tetrapyridyl Gold(III) Complexes for Hypoxic Cancer Therapy Open
Gold complexes have emerged as promising anticancer metallodrugs due to their efficient thioredoxin reductase (TrxR) inhibition, which disturbs the redox balance of cancer cells.However, in this model, the role of the ligand(s) coordinated…
View article: CCDC 2253347: Experimental Crystal Structure Determination
CCDC 2253347: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2253350: Experimental Crystal Structure Determination
CCDC 2253350: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2253353: Experimental Crystal Structure Determination
CCDC 2253353: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2253349: Experimental Crystal Structure Determination
CCDC 2253349: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2253352: Experimental Crystal Structure Determination
CCDC 2253352: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …