Ingo Stricker
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View article: Machine Learning–based Identification of Prognostic Factors for Surgical Management in Patients With NOS Sarcoma
Machine Learning–based Identification of Prognostic Factors for Surgical Management in Patients With NOS Sarcoma Open
Background: Non-otherwise specified (NOS) sarcomas, a diverse and diagnostically challenging group of mesenchymal malignancies, pose significant clinical dilemmas due to their variable clinical trajectories and therapeutic responses. This …
View article: Histology of neurogenic heterotopic ossification and comparison with its radiological expression in acute spinal cord injured patients
Histology of neurogenic heterotopic ossification and comparison with its radiological expression in acute spinal cord injured patients Open
Study design Clinical prospective study. Objectives To histologically examine puncture biopsies of early neurogenic heterotopic ossification (NHO) in spinal cord injured individuals. Setting University of Bochum, Germany. Methods After acu…
View article: THE FATE OF IMPLANTED BIOBRIDGE™ COLLAGEN MATRIX – FINDINGS IN HISTOLOGY, SCANNING, AND TRANSMISSION ELECTRON MICROSCOPY
THE FATE OF IMPLANTED BIOBRIDGE™ COLLAGEN MATRIX – FINDINGS IN HISTOLOGY, SCANNING, AND TRANSMISSION ELECTRON MICROSCOPY Open
The technique of lymphangioplasty or capillary thread drainage was historically performed with subcutaneously implanted surgical threads. It has recently been revived by introducing a thread-like aligned nanofibrillar collagen matrix (BioB…
View article: Risk Stratification with Sarculator and MSKCC in Patients with Primary and Secondary Angiosarcoma
Risk Stratification with Sarculator and MSKCC in Patients with Primary and Secondary Angiosarcoma Open
Background: Sarculator and Memorial Sloan Kettering Cancer Center (MSKCC) nomograms are freely available risk prediction scores for surgically treated patients with primary sarcomas. Due to the rarity of angiosarcomas, these scores have on…
View article: Explanted Skull Flaps after Decompressive Hemicraniectomy Demonstrate Relevant Bone Avitality-Is Their Reimplantation Worth the Risk?
Explanted Skull Flaps after Decompressive Hemicraniectomy Demonstrate Relevant Bone Avitality-Is Their Reimplantation Worth the Risk? Open
Background: Reimplantations of autologous skull flaps after decompressive hemicraniectomies (DHs) are associated with high rates of postoperative bone flap resorption (BFR). We histologically assessed the cell viability of explanted bone f…
View article: Explanted skull flaps after decompressive hemicraniectomy demonstrate relevant bone avitality. Is their reimplantation worth of the risk?
Explanted skull flaps after decompressive hemicraniectomy demonstrate relevant bone avitality. Is their reimplantation worth of the risk? Open
Objective Reimplantations of autologous skull flaps after decompressive hemicraniectomies (DH) are associated with dramatic high rates of postoperative bone flap resorption (BFR). In the context of our clinical trial DRKS00023283, we asses…
View article: Complete mesocolic excision for right colonic cancer: prospective multicentre study
Complete mesocolic excision for right colonic cancer: prospective multicentre study Open
Background Complete mesocolic excision (CME) for right colonic cancer is a more complex operation than standard right hemicolectomy but evidence to support its routine use is still limited. This prospective multicentre study evaluated the …
View article: Undifferentiated pleomorphic sarcoma of the breast with neoplastic fever: case report and genomic characterization
Undifferentiated pleomorphic sarcoma of the breast with neoplastic fever: case report and genomic characterization Open
Purpose Primary breast sarcomas are extraordinary rare, in particular undifferentiated pleomorphic sarcoma (UPS). UPS with neoplastic fever (UPS-NF) of the breast has not been reported yet. Here, we present an extended UPS-NF of the breast…
View article: Predictive factors for long-term survival after surgery for pancreatic ductal adenocarcinoma: Making a case for standardized reporting of the resection margin using certified cancer center data
Predictive factors for long-term survival after surgery for pancreatic ductal adenocarcinoma: Making a case for standardized reporting of the resection margin using certified cancer center data Open
Factors for overall survival after pancreatic ductal adenocarcinoma (PDAC) seem to be nodal status, chemotherapy administration, UICC staging, and resection margin. However, there is no consensus on the definition for tumor free resection …
View article: Combination Therapy of a Host Defense-Like Lytic Peptide and Continuous Low-Dose Doxorubicin Inhibits Tumor Growth in a Syngeneic Immunocompetent Murine Fibrosarcoma (BFS-1) Model
Combination Therapy of a Host Defense-Like Lytic Peptide and Continuous Low-Dose Doxorubicin Inhibits Tumor Growth in a Syngeneic Immunocompetent Murine Fibrosarcoma (BFS-1) Model Open
Background: The concept of a multimodality therapy in the treatment of soft tissue sarcomas (STS) has been discussed with controversy. Surgical resection with clear margins and radiation therapy remain gold standard in STS therapy. It is s…
View article: The Impact of Surgical Margins and Adjuvant Radiotherapy in Patients with Undifferentiated Pleomorphic Sarcomas of the Extremities: A Single-Institutional Analysis of 192 Patients
The Impact of Surgical Margins and Adjuvant Radiotherapy in Patients with Undifferentiated Pleomorphic Sarcomas of the Extremities: A Single-Institutional Analysis of 192 Patients Open
Background: Undifferentiated pleomorphic sarcomas are a frequent subtype within the heterogeneous group of soft tissue sarcomas. As the attainment of negative margins can be complicated at the extremities, we determined the prognostic sign…
View article: Long-term Outcome of 181 Patients With Liposarcomas of the Extremity and Truncal Wall
Long-term Outcome of 181 Patients With Liposarcomas of the Extremity and Truncal Wall Open
Negative margins were not an independent prognostic factor in our series. Tumor biology reflected by histologic grade dictated the outcome.
View article: Long-term outcomes of patients with soft tissue sarcoma of the chest wall: Analysis of the prognostic significance of microscopic margins
Long-term outcomes of patients with soft tissue sarcoma of the chest wall: Analysis of the prognostic significance of microscopic margins Open
Data on prognostic factors and treatment outcomes for chest wall soft tissue sarcomas (STS) are sparse. Wide resections with negative margins are the mainstay of therapy, but the prognostic impact of surgical margins remains controversial.…
View article: Effect of surgical margins on prognosis in aggressive fibromatosis: A single‑institutional analysis of 90�patients
Effect of surgical margins on prognosis in aggressive fibromatosis: A single‑institutional analysis of 90�patients Open
The treatment of aggressive fibromatosis poses a therapeutic challenge in an interdisciplinary setting. The extent of surgical resection is still discussed controversially. The present retrospective analysis aimed to determine prognostic f…
View article: Soft Tissue Sarcomas of the Extremities: Surgical Margins Can Be Close as Long as the Resected Tumor Has No Ink on It
Soft Tissue Sarcomas of the Extremities: Surgical Margins Can Be Close as Long as the Resected Tumor Has No Ink on It Open
Background Soft tissue sarcomas (STS) arising in the extremities pose a therapeutic challenge due to concerns of functional morbidity. Resections with negative margins are the mainstay of therapy, but the prognostic significance of surgica…
View article: A single-institutional review of 68 patients with dermatofibrosarcoma protuberans: wide re-excision after inadequate previous surgery results in a high rate of local control
A single-institutional review of 68 patients with dermatofibrosarcoma protuberans: wide re-excision after inadequate previous surgery results in a high rate of local control Open
The data from this study underscore the long-term benefit of negative margins. In our analysis, re-excisions were an effective method to achieve a high rate of local control in patients who presented after R1 or marginal R0 resection. To e…
View article: A single-institutional review of 68 patients with dermatofibrosarcoma protuberans
A single-institutional review of 68 patients with dermatofibrosarcoma protuberans Open
\(\textbf {Background:}\) Dermatofibrosarcoma protuberans (DFSP) is a cutaneous soft tissue sarcoma characterized by an indolent but aggressive local growth. Unplanned excisions with positive margins are common, and the prognostic impact o…
View article: Evaluation of the safety and efficacy of TRAIL and taurolidine use on human fibrosarcoma xenografts in vivo
Evaluation of the safety and efficacy of TRAIL and taurolidine use on human fibrosarcoma xenografts in vivo Open
Fibrosarcomas are rare malignant soft tissue tumours that exhibit a poor response to current therapeutic regimens. Previously, tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and taurolidine were observed to induce apoptos…