Ingrid Casper
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View article: Severity assessment of food allergies according to DEFASE criteria in the German healthcare system (d-DEFASE)
Severity assessment of food allergies according to DEFASE criteria in the German healthcare system (d-DEFASE) Open
Summary Background There is currently no standardized evaluation system in Germany for defining and classifying the severity of IgE-mediated food allergies (FA). Following the development of the international classification system named DE…
View article: Multiomics approaches disclose very-early molecular and cellular switches during insect-venom allergen-specific immunotherapy: an observational study
Multiomics approaches disclose very-early molecular and cellular switches during insect-venom allergen-specific immunotherapy: an observational study Open
Allergen-specific immunotherapy (AIT) induces immune tolerance, showing the highest success rate (>95%) for insect venom while a much lower chance for pollen allergy. However, the molecular switches leading to successful durable tolerance …
View article: Evaluation of ongoing mepolizumab treatment in chronic rhinosinusitis with nasal polyps
Evaluation of ongoing mepolizumab treatment in chronic rhinosinusitis with nasal polyps Open
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial inflammatory disease of the mucous membranes of the nose and paranasal sinuses. Eosinophilic inflammation is described as a common endotype. The anti-interleukin-5 (IL-5…
View article: Monitoring mepolizumab treatment in chronic rhinosinusitis with nasal polyps (CRSwNP): Discontinue, change, continue therapy?
Monitoring mepolizumab treatment in chronic rhinosinusitis with nasal polyps (CRSwNP): Discontinue, change, continue therapy? Open
Understanding the immunological basis of CRSwNP opens up new non-surgical therapeutic approaches with biologics for patients with severe, uncontrolled courses. Here, we provide recommendations for follow-up, adherence to therapy intervals,…
View article: EGPA: Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) as a special presentation of chronic rhinosinusitis with nasal polyps (CRSwNP)
EGPA: Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) as a special presentation of chronic rhinosinusitis with nasal polyps (CRSwNP) Open
Characterization of mucosal airway inflammation through biomarker determination is meaningful and occasionally makes the difference for targeted therapy.
View article: Eosinophil granulocytes in chronic inflammatory respiratory diseases and CRSwNP: Function, immunological basis, and clinical significance
Eosinophil granulocytes in chronic inflammatory respiratory diseases and CRSwNP: Function, immunological basis, and clinical significance Open
The important role of eosinophils in immunological processes in the airway mucosa is comprehensively analyzed and can serve as a basis for current and future treatment approaches.
View article: Allergen immunotherapy in house dust mite-associated allergic rhinitis: efficacy of the 300 IR mite tablet
Allergen immunotherapy in house dust mite-associated allergic rhinitis: efficacy of the 300 IR mite tablet Open
Background A perennial house dust mite-associated allergic rhinitis has a major impact on the quality of life of patients and is associated with a high socioeconomic burden. The most common symptoms of allergic rhinitis include a runny nos…
View article: Avoidance measures for mite allergy—an update
Avoidance measures for mite allergy—an update Open
House dust mites are a major source of allergens in house dust and, thus, the main trigger of perennial allergic respiratory diseases [1–5]. Scientific research on the life cycle, diet, and reproductive behavior of dust mites and on the bi…
View article: Indicating biologics for chronic rhinosinusitis with nasal polyps (CRSwNP)
Indicating biologics for chronic rhinosinusitis with nasal polyps (CRSwNP) Open
Summary Background Chronic rhinosinusitis with nasal polyps (CRSwNP), an inflammatory disease of the paranasal mucosa, is primarily characterized by type 2 inflammation. Three antibodies (dupilumab, omalizumab, and mepolizumab) are now app…
View article: Epithelial immune regulation of inflammatory airway diseases: Chronic rhinosinusitis with nasal polyps (CRSwNP)
Epithelial immune regulation of inflammatory airway diseases: Chronic rhinosinusitis with nasal polyps (CRSwNP) Open
Treatment with TSLP-blocking monoclonal antibodies could therefore open up interesting therapeutic options. The long-term safety and effectiveness of TSLP blockade has yet to be investigated.
View article: Immunological background for treatments with biologicals in CRSwNP
Immunological background for treatments with biologicals in CRSwNP Open
Background: Chronic rhinosinusitis (CRS) is a heterogeneous and multifactorial inflammatory disease of the nasal and paranasal mucosa. To date, no internationally standardized uniform classification has been developed for this disease. Usu…
View article: Therapy of allergic rhinitis in routine care: evidence-based benefit assessment of freely combined use of various active ingredients
Therapy of allergic rhinitis in routine care: evidence-based benefit assessment of freely combined use of various active ingredients Open
Background Allergic rhinitis (AR) continues to increase in incidence and is the most common allergic disease. If abstention of the allergen triggering substances is not possible, allergen-specific immunotherapy (AIT) as causal treatment or…
View article: Correction to “ARIA guideline 2019: treatment of allergic rhinitis in the German health system”
Correction to “ARIA guideline 2019: treatment of allergic rhinitis in the German health system” Open
Correction to: Allergo J Int 2019 https://doi.org/10.1007/s40629-019-00110-9 Affiliation and disclaimer have been misrepresented and are hereby corrected: Vera Mahler: Affiliation: Med. Faculty, Friedrich-Alexander-University (FAU) Erlange…
View article: Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic
Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic Open
The use of biologicals for the treatment of bronchial asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps, and spontaneous urticaria should be continued as usual in patients without suspected infection or proven SARS-CoV-2 …
View article: ARIA guideline 2019: treatment of allergic rhinitis in the German health system
ARIA guideline 2019: treatment of allergic rhinitis in the German health system Open
Background The number of patients affected by allergies is increasing worldwide. The resulting allergic diseases are leading to significant costs for health care and social systems. Integrated care pathways are needed to enable comprehensi…
View article: ARIA guideline 2019: treatment of allergic rhinitis in the German health system
ARIA guideline 2019: treatment of allergic rhinitis in the German health system Open
A comprehensive ICP guideline can reflect real-life care better than traditional guideline models.
View article: Evaluation of land use land cover changes using remote sensing Landsat images and pastoralists perceptions on range cover changes in Borana rangelands, Southern Ethiopia
Evaluation of land use land cover changes using remote sensing Landsat images and pastoralists perceptions on range cover changes in Borana rangelands, Southern Ethiopia Open
Studies on land-use/land cover (LULC) changes through remote sensing techniques represent vital tools for generating rational information for sound decision making on natural resources management. Related to the launching of the first Land…