Ingrid Saba
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Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus Open
MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered thera…
Structure of MHC-Independent TCRs and Their Recognition of Native Antigen CD155 Open
During normal T cell development in the thymus, αβ TCRs signal immature thymocytes to differentiate into mature T cells by binding to peptide–MHC ligands together with CD4/CD8 coreceptors. Conversely, in MHC and CD4/CD8 coreceptor-deficien…
Engineering Tissues without the Use of a Synthetic Scaffold: A Twenty-Year History of the Self-Assembly Method Open
Twenty years ago, Dr. François A. Auger, the founder of the Laboratory of Experimental Organogenesis (LOEX), introduced the self-assembly technique. This innovative technique relies on the ability of dermal fibroblasts to produce and assem…
New and Improved Tissue Engineering Techniques: Production of Exogenous Material-Free Stroma by the Self-Assembly Technique Open
Tissue engineering results from the use of cells and scaffolds to reproduce structural and spatial organization or function of a tissue. The Production of an ideal engineered tissue depends on its designed purpose. For clinical application…
Development of a three-dimensional cell culture tissue that mimics female genital mucosae as an infection model Open
Event Abstract Back to Event Development of a three-dimensional cell culture tissue that mimics female genital mucosae as an infection model Ingrid Saba1, Corinne Barat2, Maude Leclerc1, Hazem O. Orabi1, Michel J. Tremblay2 and Stephane Bo…