Explanipedia

Outcome of patients scheduled for CRS and HIPEC yet only undergoing explorative laparotomy Open

Valentinus Valdimarsson, Ingvar Syk, Victor J. Verwaal · 2025

Background: Some patients scheduled for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) only undergo explorative laparotomy (open/close procedure) due to extensive tumor spread or challenges in achieving c…

Postoperative leukopenia after cytoreductive surgery and hypertherm intraperitoneal chemotherapy for colorectal carcinomatosis– causes and implication on outcomes in a population-based study Open

Mattias Lepsenyi, Valentinus Valdimarsson, Nader Algethami, Henrik Thorlacius, Lana Ghanipour , et al. · 2025

Comparison of the C-REX LapAid and Circular Stapled Colorectal Anastomoses in an Experimental Model Open

Dadi Vilhjalmsson, Anders Grönberg, Ingvar Syk, Henrik Thorlacius · 2025

Introduction: The rate of colorectal anastomotic leakage has remained unchanged for the last decades. The limitations of current anastomotic methods have generated an interest in alternative anastomotic techniques, such as compression anas…

More vs Less Frequent Follow-Up Testing and 10-Year Mortality in Patients With Stage II or III Colorectal Cancer Open

Henrik Toft Sørensen, Erzsébet Horváth–Puhó, Sune Høirup Petersen, Torben Jørgensen, Ingvar Syk , et al. · 2024

Importance Although intensive follow-up of patients after curative surgery for colorectal cancer is common in clinical practice, evidence for a long-term survival benefit of more frequent testing is limited. Objective To examine overall an…

72196 - Outcome is not associated with advanced age after CRS and HIPEC for Colorectal peritoneal metastases: a population-based study Open

Tamara Yousef Yacoub, Peter Matthiessen, Wilhelm Graf, Peter Cashin, Gabriella Jansson Palmer , et al. · 2024

Introduction Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) has entailed better prognosis and overall survival for patients with peritoneal metastasis (PM) from colorectal cancer (CRC). However, data on pe…

A Validation of the Swedish Colorectal Cancer Register – With Focus on Histopathology, Complications and Recurrences Open

Örvar Arnarson, Peter Moberger, Filip Sköldberg, Kenneth Smedh, Helgi Birgisson , et al. · 2024

Validation of the SCRCR data showed high validity of pathology data and recurrence rates, whereas detailed data on recurrence were not as good. Data on postoperative complications were less reliable, although the incidence and Clavien-Dind…

Correction: CXCL2-CXCR2 axis mediates αV integrin-dependent peritoneal metastasis of colon cancer cells Open

Mattias Lepsenyi, Nader Algethami, Amr Al‐Haidari, Anwar Algaber, Ingvar Syk , et al. · 2024

ACBC Study Protocol – Acute Colon Resection Versus Bridge to Colon Surgery with Stent Placement or Stoma Diversion: A Prospective Cohort Study Open

Tobias Axmarker, Fredrik Jörgren, Kalle Landerholm, Daniel Asklid, Niklas Damkilde , et al. · 2024

Background: Approximately 70% of all colon cancer emergencies result from colonic obstruction. Data from the Swedish Colorectal Cancer Registry indicate that patients undergoing emergency surgical resections for colon cancer face higher ov…

Secondary cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for recurrent colorectal peritoneal metastases Open

Peter Cashin, Dan Asplund, Elinor Bexe Lindskog, Lana Ghanipour, Ingvar Syk , et al. · 2024

After matching for relevant factors, the hazard ratio for death was significantly reduced in patients who were offered a secondary CRS + HIPEC procedure for recurrent peritoneal disease. Selection bias is inherent, but survival outcomes we…

Risk of recurrence in high-risk T1 colon cancer following endoscopic and surgical resection: registry-based cohort study Open

Emelie Nilsson, Erik Wetterholm, Ingvar Syk, Henrik Thorlacius, Carl-Fredrik Rönnow · 2024

Background Endoscopic resection of T1 colon cancer (CC) is currently limited by guidelines related to risk of lymph node metastases. However, clinical outcome following endoscopic and surgical resection is poorly investigated. Method A ret…

Efficacy of hyperthermic intraperitoneal chemotherapy in colorectal cancer: A phase I and III open label randomized controlled registry-based clinical trial protocol Open

Lana Ghanipour, Gabriella Jansson Palmer, Per J. Nilsson, Caroline Nordenvall, Jan‐Erik Frödin , et al. · 2024

Standard treatment for patient with peritoneal metastases from colorectal cancer is cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). In recent years, the efficacy of oxaliplatin-based HIPEC has been challe…

Author Correction: MicroRNA-340-5p inhibits colon cancer cell migration via targeting of RhoA Open

Anwar Algaber, Amr Al‐Haidari, Raed Madhi, Milladur Rahman, Ingvar Syk , et al. · 2024

Correction to: Evolution of surgical approach to rectal cancer resection: A multinational registry assessment Open

Julie Sijmons, Jan Willem T. Dekker, Jurriaan B. Tuynman, Helen Mohan, Philip Smart , et al. · 2024

Evolution of surgical approach to rectal cancer resection: A multinational registry assessment Open

Julie Sijmons, Jan Willem T. Dekker, Jurriaan B. Tuynman, Helen Mohan, Philip Smart , et al. · 2024

Risk Factors for Postoperative Complications Following Resection of Colorectal Liver Metastases and the Impact on Long‐Term Survival: A Population‐Based National Cohort Study Open

Peter Scherman, Ingvar Syk, Erik Holmberg, Peter Naredi, Magnus Rizell · 2023

Background Postoperative complications (POCs) following resection of colorectal liver metastases (CRLM) are common. The objective of this study was to evaluate risk factors for developing complications and their impact on survival consider…

Transanal formation of anastomosis using C-REX device is feasible and effective in high anterior resection Open

Dadi Vilhjalmsson, Mattias Lepsenyi, Ingvar Syk, Anders Grönberg, Henrik Thorlacius · 2023

CRCBaSe: a Swedish register-based resource for colorectal adenocarcinoma research Open

Caroline E. Weibull, Sol Erika Boman, Bengt Glimelius, Ingvar Syk, Peter Matthiessen , et al. · 2023

To facilitate high-quality register-based research on colorectal cancer (CRC) in Sweden by constructing a database consisting of CRC patients, matched comparators, and relatives. Patients with adenocarcinoma in the colon and/or rectum were…

Abdominal Closure With Reinforcing Suture Decreases Incisional Hernia Incidence After CRS/HIPEC Open

Charlotta Wenzelberg, Ulf Petersson, Ingvar Syk, Olle Ekberg, Peder Rogmark · 2023

Background: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) entails several risk factors for incisional hernia (IH). A few reports available showing incidences between 7% and 17%. At our institution fascia…

High resection rates of colorectal liver metastases after standardized follow-up and multimodal management: an outcome study within the COLOFOL trial Open

Peter Scherman, Pernilla Hansdotter, Erik Holmberg, Frank Viborg Mortensen, Sune Høirup Petersen , et al. · 2023

A high proportion of metachronous CRLM was possible to treat with curative intent, yielding high survival rates. More intense follow-up after colorectal cancer resection might be of value in high-risk patients.

Transanal formation of anastomosis using C-REX device is safe and effective in high anterior resection Open

Dadi Vilhjalmsson, Mattias Lepsenyi, Ingvar Syk, Anders Grönberg, Henrik Thorlacius · 2023

Purpose C-REX is a novel instrument for creating stapleless colorectal anastomosis by compression. The aim of this study was to evaluate the safety and effectiveness of C-REX in open- and laparoscopic high anterior resections. Methods A pr…

Who should operate patients presenting with emergent colon cancer? A comparison of short- and long-term outcome depending on surgical sub-specialization Open

Örvar Arnarson, Ingvar Syk, Salma Butt · 2023

Treatment and survival of patients with metachronous colorectal lung metastases Open

Pernilla Hansdotter, Peter Scherman, Maziar Nikberg, Sune Høirup Petersen, Erik Holmberg , et al. · 2023

Introduction The lungs are the second most common site for metachronous metastases in colorectal cancer. No treatment algorithm is established, and the role of adjuvant chemotherapy is unclear. This study aimed to map pulmonary recurrences…

Low‐dose aspirin use and colorectal cancer survival in 32,195 patients—A national cohort study Open

Mehrnoosh Shahrivar, Caroline E. Weibull, Karin E. Smedby, Bengt Glimelius, Ingvar Syk , et al. · 2022

Background Results from previous studies indicate that use of aspirin may improve colorectal cancer (CRC) survival. The aim of this study was to assess whether use of aspirin influences overall survival or CRC‐specific survival in an unsel…

Delineating the intra-patient heterogeneity of molecular alterations in treatment-naïve colorectal cancer with peritoneal carcinomatosis Open

Christina Siesing, Alexandra Petersson, Thora Ulfarsdottir, Subhayan Chattopadhyay, Björn Nodin , et al. · 2022

O10 REINFORCED TENSION LINE SUTURE RESULTS IN LOW INCISIONAL HERNIA RATE AFTER CRS/HIPEC OPERATIONS Open

Charlotta Wenzelberg, Ulf Petersson, Ingvar Syk, Peder Rogmark · 2021

Aim Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis entails several risk factors for incisional hernia (IH). At our institution fascia closure has been performed in a 4:1 mann…

Cost comparisons of endoscopic and surgical resection of stage T1 rectal cancer Open

Victoria Arthursson, Roberto Rosén, Jenny M. Norlin, Katarina Gralén, Ervin Tόth , et al. · 2021

Background and study aims Management of T1 rectal cancer is complex and includes several resection methods, making cost comparisons challenging. The aim of this study was to compare costs of endoscopic and surgical resection and to investi…

Patterns and resectability of colorectal cancer recurrences: outcome study within the COLOFOL trial Open

Pernilla Hansdotter, Peter Scherman, Sune Høirup Petersen, Martynas Mikalonis, Erik Holmberg , et al. · 2021

Background Improvements in surgery, imaging, adjuvant treatment, and management of metastatic disease have led to modification of previous approaches regarding the risk of recurrence and prognosis in colorectal cancer. The aims of this stu…

CXCL2-CXCR2 axis mediates αV integrin-dependent peritoneal metastasis of colon cancer cells Open

Mattias Lepsenyi, Nader Algethami, Amr Al‐Haidari, Anwar Algaber, Ingvar Syk , et al. · 2021

Peritoneal metastasis is an insidious aspect of colorectal cancer. The aim of the present study was to define mechanisms regulating colon cancer cell adhesion and spread to peritoneal wounds after abdominal surgery. Mice was laparotomized …

No benefit of more intense follow-up after surgery for colorectal cancer in the risk group with elevated CEA levels – An analysis within the COLOFOL randomized clinical trial Open

Monika Egenvall, Anna Martling, Katalin Veres, Erzsébet Horváth–Puhó, Torben Jørgensen , et al. · 2021

Long-term survival after self-expanding metallic stent or stoma decompression as bridge to surgery in acute malignant large bowel obstruction Open

Tobias Axmarker, Märta Leffler, Mattias Lepsenyi, Henrik Thorlacius, Ingvar Syk · 2021

Aim Self-expanding metallic stents (SEMS) as bridge to surgery have been questioned due to the fear of perforation and tumour spread. This study aimed to compare SEMS and stoma as bridge to surgery in acute malignant large bowel obstructio…

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