Ingvild Birschmann
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View article: Rapid assessment of direct oral anticoagulants in acute stroke—An educational systematic review
Rapid assessment of direct oral anticoagulants in acute stroke—An educational systematic review Open
Purpose: To provide an overview on commercially available point-of-care tests (POCT) for rapid assessment of direct oral anticoagulant (DOAC) activity, their diagnostic accuracy in identifying blood samples containing clinically relevant D…
View article: The Diagnostic Assessment of Platelet Function Defects - Part 2: Update on Platelet Disorders
The Diagnostic Assessment of Platelet Function Defects - Part 2: Update on Platelet Disorders Open
Congenital platelet disorders are rare and targeted treatment is usually not possible. Inherited platelet function disorders (iPFDs) can affect surface receptors and multiple platelet responses such as defects of platelet granules, signal …
View article: The Diagnostic Assessment of Inherited Platelet Function Defects - Part 1: An Overview of the Diagnostic Approach and Laboratory Methods
The Diagnostic Assessment of Inherited Platelet Function Defects - Part 1: An Overview of the Diagnostic Approach and Laboratory Methods Open
In this article, our goal is to offer an introduction and overview of the diagnostic approach to inherited platelet function defects (iPFDs) for clinicians and laboratory personnel who are beginning to engage in the field. We describe the …
View article: Anticoagulant Management After Emergency Surgery or Major Bleeding in Anticoagulated Patients—Results of the Prospective RADOA Registry
Anticoagulant Management After Emergency Surgery or Major Bleeding in Anticoagulated Patients—Results of the Prospective RADOA Registry Open
Background: Major bleeding or emergency surgery are the most frequently observed emergency situations in patients anticoagulated with vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs). The restart of anticoagulation after …
View article: Aspirin resistance in patients with ventricular assist devices: A follow‐up study
Aspirin resistance in patients with ventricular assist devices: A follow‐up study Open
Background Despite combined anticoagulation therapy consisting of a vitamin K antagonist and an antiplatelet agent, thromboembolic complications often occur in patients with a left ventricular assist device (LVAD). In addition, bleeding ev…
View article: German Society for Clinical Chemistry and Laboratory Medicine – areas of expertise: Division reports from the German Congress of Laboratory Medicine 2022 in Mannheim, 13–14 October 2022
German Society for Clinical Chemistry and Laboratory Medicine – areas of expertise: Division reports from the German Congress of Laboratory Medicine 2022 in Mannheim, 13–14 October 2022 Open
The programme of the German Congress for Laboratory Medicine 2022 was essentially designed by the divisions of the German Society for Clinical Chemistry and Laboratory Medicine (DGKL). Almost all chairpersons of the divisions organised a 9…
View article: Clinical Course and Management of Patients with Emergency Surgery Treated with Direct Oral Anticoagulants or Vitamin K Antagonists—Results of the German Prospective RADOA-Registry
Clinical Course and Management of Patients with Emergency Surgery Treated with Direct Oral Anticoagulants or Vitamin K Antagonists—Results of the German Prospective RADOA-Registry Open
(1) Background: The clinical management of anticoagulated patients treated with direct oral anticoagulants (DOAC) or Vitamin K antagonists (VKA) needing emergency surgery is challenging. (2) Methods: The prospective German RADOA registry i…
View article: PB1080 Clinical Course and Management of Patients with Emergency Surgeries Treated with Direct Oral Anticoagulants or Vitamin K Antagonists – Results of the German Prospective RADOA-Registry
PB1080 Clinical Course and Management of Patients with Emergency Surgeries Treated with Direct Oral Anticoagulants or Vitamin K Antagonists – Results of the German Prospective RADOA-Registry Open
Background: Vitamin K antagonists are the anticoagulation therapy available for the primary and secondary prevention of venous and arterial thrombosis.The strict control of anticoagulant therapy through the INR reduces the risk of thrombos…
View article: PB1177 Preliminary Performance Data of an Anti-Xa Assay for the Quantitative Determination of Edoxaban
PB1177 Preliminary Performance Data of an Anti-Xa Assay for the Quantitative Determination of Edoxaban Open
Correlation of platelet aggregation using EBCT and non-
View article: Changes in the Proteome of Platelets from Patients with Critical Progression of COVID-19
Changes in the Proteome of Platelets from Patients with Critical Progression of COVID-19 Open
Platelets, the smallest cells in human blood, known for their role in primary hemostasis, are also able to interact with pathogens and play a crucial role in the immune response. In severe coronavirus disease 2019 (COVID-19) cases, platele…
View article: Immature platelets in COVID-19
Immature platelets in COVID-19 Open
Platelets play a critical role in immune response. Coronavirus disease 2019 (COVID-19) patients with a severe course often show pathological coagulation parameters including thrombocytopenia, and at the same time the proportion of immature…
View article: Pharmacokinetics of Phenprocoumon in Emergency Situations–Results of the Prospective Observational RADOA-Registry (Reversal Agent Use in Patients Treated with Direct Oral Anticoagulants or Vitamin K Antagonists Registry)
Pharmacokinetics of Phenprocoumon in Emergency Situations–Results of the Prospective Observational RADOA-Registry (Reversal Agent Use in Patients Treated with Direct Oral Anticoagulants or Vitamin K Antagonists Registry) Open
Background: Phenprocoumon has been used as an oral anticoagulant in patients with thromboembolic disease for more than 40 years. So far its pharmacokinetics have not been analyzed in emergency situations. Methods: Phenprocoumon-treated pat…
View article: The Human Myofibroblast Marker Xylosyltransferase-I: A New Indicator for Macrophage Polarization
The Human Myofibroblast Marker Xylosyltransferase-I: A New Indicator for Macrophage Polarization Open
Chronic inflammation and excessive synthesis of extracellular matrix components, such as proteoglycans (PG), by fibroblast- or macrophage-derived myofibroblasts are the hallmarks of fibrotic diseases, including systemic sclerosis (SSc). Hu…
View article: Retrospective study shows that early administration of convalescent plasma in hospitalized COVID‐19 patients may have a positive effect on disease progression
Retrospective study shows that early administration of convalescent plasma in hospitalized COVID‐19 patients may have a positive effect on disease progression Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) which can occur with varying severity. Hospitalization rates and morbidity are particularly elevated in older adults and those with com…
View article: The impact of acquired coagulation factor XIII deficiency in traumatic bleeding and wound healing
The impact of acquired coagulation factor XIII deficiency in traumatic bleeding and wound healing Open
Factor XIII (FXIII) is a protein involved in blood clot stabilisation which also plays an important role in processes including trauma, wound healing, tissue repair, pregnancy, and even bone metabolism. Following surgery, low FXIII levels …
View article: Evidence of Long-Lasting Humoral and Cellular Immunity against SARS-CoV-2 Even in Elderly COVID-19 Convalescents Showing a Mild to Moderate Disease Progression
Evidence of Long-Lasting Humoral and Cellular Immunity against SARS-CoV-2 Even in Elderly COVID-19 Convalescents Showing a Mild to Moderate Disease Progression Open
We here evaluate the humoral and cellular immune response against SARS-CoV-2 in 41 COVID-19 convalescents. As previous studies mostly included younger individuals, one advantage of our study is the comparatively high mean age of the conval…
View article: Pharmacokinetics of Direct Oral Anticoagulants in Emergency Situations: Results of the Prospective Observational RADOA-Registry
Pharmacokinetics of Direct Oral Anticoagulants in Emergency Situations: Results of the Prospective Observational RADOA-Registry Open
Background Direct oral anticoagulants (DOACs) are increasingly used worldwide. Little is known so far about their pharmacokinetics in emergency situations. Methods A prospective, observational registry was performed to determine the clinic…
View article: Pharmacokinetics and Biologic Activity of Apixaban in Healthy Dogs
Pharmacokinetics and Biologic Activity of Apixaban in Healthy Dogs Open
Thrombosis is common in critically ill dogs and causes considerable morbidity and mortality. The direct factor Xa inhibitor apixaban is safe, efficacious, and convenient in humans. This study aimed to determine the pharmacokinetics (PK), b…
View article: Point-of-care testing for emergency assessment of coagulation in patients treated with direct oral anticoagulants including edoxaban
Point-of-care testing for emergency assessment of coagulation in patients treated with direct oral anticoagulants including edoxaban Open
Background Direct oral anticoagulants (DOAC) including edoxaban are increasingly used for stroke prevention in atrial fibrillation. Despite treatment, annual stroke rate in these patients remains 1–2%. Rapid assessment of coagulation would…
View article: Graft-derived Cell-free DNA as a Noninvasive Biomarker of Cardiac Allograft Rejection: A Cohort Study on Clinical Validity and Confounding Factors
Graft-derived Cell-free DNA as a Noninvasive Biomarker of Cardiac Allograft Rejection: A Cohort Study on Clinical Validity and Confounding Factors Open
Background. Circulating graft-derived cell-free DNA (dd-cfDNA) is a new marker of cardiac allograft damage that is used for noninvasive rejection diagnostics. We performed dd-cfDNA (%) in heart transplant recipients during the first posttr…
View article: Evidence of long-lasting humoral and cellular immunity against SARS-CoV-2 even in elderly COVID-19 convalescents showing a mild to moderate disease progression
Evidence of long-lasting humoral and cellular immunity against SARS-CoV-2 even in elderly COVID-19 convalescents showing a mild to moderate disease progression Open
After the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in China in late 2019, a pandemic evolved that has claimed millions of lives so far. While about 80 % of infections cause mild or…
View article: Retrospective analysis of 426 donors of a convalescent collective after mild COVID-19
Retrospective analysis of 426 donors of a convalescent collective after mild COVID-19 Open
Background The novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread across the world. The aim of our study was to characterize mild courses and to determine the a…
View article: Specific Point-of-Care Testing of Coagulation in Patients Treated with Dabigatran
Specific Point-of-Care Testing of Coagulation in Patients Treated with Dabigatran Open
Background and Purpose Accurate and rapid assessment of coagulation status is necessary to guide thrombolysis or reversal of anticoagulation in stroke patients, but commercially available point-of-care (POC) assays are not suited for coagu…
View article: Point-of-care testing of coagulation in patients treated with edoxaban
Point-of-care testing of coagulation in patients treated with edoxaban Open
Edoxaban, alongside other direct oral anticoagulants (DOAC), is increasingly used for prevention of thromboembolism, including stroke. Despite DOAC therapy, however, annual stroke rate in patients with atrial fibrillation remains 1–2%. Rap…
View article: Pharmacokinetics and Pharmacodynamics of an Oral Formulation of Apixaban in Horses After Oral and Intravenous Administration
Pharmacokinetics and Pharmacodynamics of an Oral Formulation of Apixaban in Horses After Oral and Intravenous Administration Open
Horses with inflammatory and infectious disorders are often treated with injectable heparin anticoagulants to prevent thrombotic complications. In humans, a new class of direct oral acting anticoagulants (DOAC) appear as effective as hepar…
View article: Limitations of Specific Coagulation Tests for Direct Oral Anticoagulants: A Critical Analysis
Limitations of Specific Coagulation Tests for Direct Oral Anticoagulants: A Critical Analysis Open
Background During treatment with direct oral anticoagulants ( DOAC ), coagulation assessment is required before thrombolysis, surgery, and if anticoagulation reversal is evaluated. Limited data support the accuracy of DOAC ‐specific coagul…