Inka C. Didelija
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View article: Enteral and intravenous supplementation of arginine and citrulline fail to prevent necrotizing enterocolitis in preterm neonatal pigs
Enteral and intravenous supplementation of arginine and citrulline fail to prevent necrotizing enterocolitis in preterm neonatal pigs Open
Background Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in preterm infants with a morality rate that approaches 50%. Arginine has been widely studied in the field of clinical nutrition as a supplement for p…
View article: Elevated level of extracellular vimentin is associated with an increased fibrin formation potential in sepsis: ex vivo swine study
Elevated level of extracellular vimentin is associated with an increased fibrin formation potential in sepsis: ex vivo swine study Open
View article: Citrulline and ADI-PEG20 reduce inflammation in a juvenile porcine model of acute endotoxemia
Citrulline and ADI-PEG20 reduce inflammation in a juvenile porcine model of acute endotoxemia Open
Background Arginine is a conditionally essential amino acid that is depleted in critically ill or surgical patients. In pediatric and adult patients, sepsis results in an arginine-deficient state, and the depletion of plasma arginine is as…
View article: PB0790 Pediatric Swine Model of Escherichia coli Sepsis - Induced Disseminated Intravascular Coagulation (DIC) and Multiple Organ Dysfunction Syndrome (MODS)
PB0790 Pediatric Swine Model of Escherichia coli Sepsis - Induced Disseminated Intravascular Coagulation (DIC) and Multiple Organ Dysfunction Syndrome (MODS) Open
Background: Sepsis-induced DIC is associated with a high mortality.Currently, no therapy exists for sepsis and/or DIC other than supportive care.We previously established a swine model of Staphylococcus aureus sepsis-induced coagulopathy.U…
View article: Pediatric Swine Model of Methicillin-Resistant Staphylococcus aureus Sepsis-Induced Coagulopathy, Disseminated Microvascular Thrombosis, and Organ Injuries
Pediatric Swine Model of Methicillin-Resistant Staphylococcus aureus Sepsis-Induced Coagulopathy, Disseminated Microvascular Thrombosis, and Organ Injuries Open
CONTEXT: Sepsis-induced coagulopathy leading to disseminated microvascular thrombosis is associated with high mortality and has no existing therapy. Despite the high prevalence of Gram-positive bacterial sepsis, especially methicillin-resi…
View article: Blood Flow Within Bioengineered 3D Printed Vascular Constructs Using the Porcine Model
Blood Flow Within Bioengineered 3D Printed Vascular Constructs Using the Porcine Model Open
Recently developed biofabrication technologies are enabling the production of three-dimensional engineered tissues containing vascular networks which can deliver oxygen and nutrients across large tissue volumes. Tissues at this scale show …
View article: Correction: A randomized trial to study the comparative efficacy of phenylbutyrate and benzoate on nitrogen excretion and ureagenesis in healthy volunteers
Correction: A randomized trial to study the comparative efficacy of phenylbutyrate and benzoate on nitrogen excretion and ureagenesis in healthy volunteers Open
View article: Pegylated arginine deiminase depletes plasma arginine but maintains tissue arginine availability in young pigs
Pegylated arginine deiminase depletes plasma arginine but maintains tissue arginine availability in young pigs Open
Pegylated arginine deiminase depletes circulating arginine, but the citrulline generated is utilized by multiple tissues to regenerate arginine and sustain local arginine availability. Preempting the arginine depletion that occurs as resul…
View article: Modeling age‐dependent developmental changes in the expression of genes involved in citrulline synthesis using pig enteroids
Modeling age‐dependent developmental changes in the expression of genes involved in citrulline synthesis using pig enteroids Open
Under culture conditions used in our study, enteroids derived from jejunal crypts of pigs at different ages failed to replicate the gene expression observed in whole tissue and whole body citrulline production. Additional extracellular cue…
View article: Arginase II Plays a Central Role in the Sexual Dimorphism of Arginine Metabolism in C57BL/6 Mice
Arginase II Plays a Central Role in the Sexual Dimorphism of Arginine Metabolism in C57BL/6 Mice Open
View article: Developmental changes in the utilization of citrulline by neonatal pigs
Developmental changes in the utilization of citrulline by neonatal pigs Open
Developmental changes in the renal expression and activity of argininosuccinate synthase (ASS1) and argininosuccinate lyase (ASL), enzymes that use citrulline for the production of arginine, have been reported. Thus, the ability of neonate…
View article: SEPSIS CAUSES DIAPHRAGM DYSFUNCTION INDEPENDENT OF MECHANICAL VENTILATION IN A PEDIATRIC SWINE MODEL OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) SEPSIS-INDUCED MULTIPLE ORGAN DYSFUNCTION SYNDROME (MODS)
SEPSIS CAUSES DIAPHRAGM DYSFUNCTION INDEPENDENT OF MECHANICAL VENTILATION IN A PEDIATRIC SWINE MODEL OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) SEPSIS-INDUCED MULTIPLE ORGAN DYSFUNCTION SYNDROME (MODS) Open
View article: Citrulline Generation Test: What Does It Measure?
Citrulline Generation Test: What Does It Measure? Open
Background The citrulline generation test (CGT) has been proposed as a tool to determine gut function. However, the increase in plasma citrulline concentration that follows a bolus dose of alanyl‐glutamine may also result from a reduction …
View article: Ex Vivo Enteroids Recapitulate In Vivo Citrulline Production in Mice
Ex Vivo Enteroids Recapitulate In Vivo Citrulline Production in Mice Open
View article: The Citrulline Recycling Pathway Sustains Cardiovascular Function in Arginine-Depleted Healthy Mice, but Cannot Sustain Nitric Oxide Production during Endotoxin Challenge
The Citrulline Recycling Pathway Sustains Cardiovascular Function in Arginine-Depleted Healthy Mice, but Cannot Sustain Nitric Oxide Production during Endotoxin Challenge Open
View article: A randomized trial to study the comparative efficacy of phenylbutyrate and benzoate on nitrogen excretion and ureagenesis in healthy volunteers
A randomized trial to study the comparative efficacy of phenylbutyrate and benzoate on nitrogen excretion and ureagenesis in healthy volunteers Open
View article: Ablation of Arginase II Spares Arginine and Abolishes the Arginine Requirement for Growth in Male Mice
Ablation of Arginase II Spares Arginine and Abolishes the Arginine Requirement for Growth in Male Mice Open
View article: The intestinal-renal axis for arginine synthesis is present and functional in the neonatal pig
The intestinal-renal axis for arginine synthesis is present and functional in the neonatal pig Open
The intestinal-renal axis for endogenous arginine synthesis is an interorgan process in which citrulline produced in the small intestine is utilized by the kidney for arginine synthesis. The function of this axis in neonates has been quest…
View article: Plasma Glutamine Is a Minor Precursor for the Synthesis of Citrulline: A Multispecies Study
Plasma Glutamine Is a Minor Precursor for the Synthesis of Citrulline: A Multispecies Study Open
View article: Supplemental Citrulline Is More Efficient Than Arginine in Increasing Systemic Arginine Availability in Mice
Supplemental Citrulline Is More Efficient Than Arginine in Increasing Systemic Arginine Availability in Mice Open
View article: Dietary Arginine Requirements for Growth Are Dependent on the Rate of Citrulline Production in Mice
Dietary Arginine Requirements for Growth Are Dependent on the Rate of Citrulline Production in Mice Open
View article: Arginine Depletion by Arginine Deiminase Does Not Affect Whole Protein Metabolism or Muscle Fractional Protein Synthesis Rate in Mice
Arginine Depletion by Arginine Deiminase Does Not Affect Whole Protein Metabolism or Muscle Fractional Protein Synthesis Rate in Mice Open
Due to the absolute need for arginine that certain cancer cells have, arginine depletion is a therapy in clinical trials to treat several types of cancers. Arginine is an amino acids utilized not only as a precursor for other important mol…