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View article: Maternal antibiotic exposure-mediated alterations in basal, and allergen-induced lung function are associated with altered recruitment of eosinophils to the developing lung
Maternal antibiotic exposure-mediated alterations in basal, and allergen-induced lung function are associated with altered recruitment of eosinophils to the developing lung Open
Introduction Early-life dysbiosis is associated with increased risk of asthma development but the underlying mechanisms remain unclear. Although eosinophils have been reported in the developing lung, their contributions to alveolar morphog…
View article: Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice
Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice Open
Microbial maturation disrupted by early-life dysbiosis has been linked with increased asthma risk and severity; however, the immunological mechanisms underpinning this connection are poorly understood. We sought to understand how delaying …
View article: Intravital imaging of mucus transport in asthmatic mice using microscopic optical coherence tomography
Intravital imaging of mucus transport in asthmatic mice using microscopic optical coherence tomography Open
Asthma is one of the most common chronic diseases. Mucus overproduction is consistently linked to asthma morbidity and mortality. Despite the knowledge of the importance of mucus, little data exist on how mucus is transported in asthma and…
View article: Prenatal antibiotics exposure does not influence experimental allergic asthma in mice
Prenatal antibiotics exposure does not influence experimental allergic asthma in mice Open
Changes in microbiome (dysbiosis) contribute to severity of allergic asthma. Preexisting epidemiological studies in humans correlate perinatal dysbiosis with increased long-term asthma severity. However, these studies cannot discriminate b…
View article: Distribution and Interaction of Murine Pulmonary Phagocytes in the Naive and Allergic Lung
Distribution and Interaction of Murine Pulmonary Phagocytes in the Naive and Allergic Lung Open
The division of labor between pulmonary phagocytic subsets [macrophage/monocyte and dendritic cell (DC) subpopulations] has been described at the functional level. However, whether these lung phagocytes also display unique spatial distribu…
View article: Differential regulation of C5a receptor 1 in innate immune cells during the allergic asthma effector phase
Differential regulation of C5a receptor 1 in innate immune cells during the allergic asthma effector phase Open
C5a drives airway constriction and inflammation during the effector phase of allergic asthma, mainly through the activation of C5a receptor 1 (C5aR1). Yet, C5aR1 expression on myeloid and lymphoid cells during the allergic effector phase i…
View article: Origin, Localization, and Immunoregulatory Properties of Pulmonary Phagocytes in Allergic Asthma
Origin, Localization, and Immunoregulatory Properties of Pulmonary Phagocytes in Allergic Asthma Open
Allergic asthma is a chronic inflammatory disease of the airways that is driven by maladaptive T helper 2 (Th2) and Th17 immune responses against harmless, airborne substances. Pulmonary phagocytes represent the first line of defense in th…