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View article: Oxygen regulates proliferation and phenotype in the RS0 SDH-deficient pheochromocytoma cell line
Oxygen regulates proliferation and phenotype in the RS0 SDH-deficient pheochromocytoma cell line Open
The RS0 cell line is a rat-derived pheochromocytoma line developed as a model to study pheochromocytoma/paraganglioma caused by hereditary mutations of the SDHB gene. Previous studies demonstrated that xenografts of the RS0 parent tumor re…
View article: A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/− rats
A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/− rats Open
27 part 6, pages 337-354.The error relates to the artwork of Table 1 on page 346, in which the units were given in micromoles per milligram of tissue, when the units should have been given in nanomoles per milligram of tissue.
View article: A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/− rats
A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/− rats Open
Tumors caused by loss-of-function mutations in genes encoding TCA cycle enzymes have been recently discovered and are now of great interest. Mutations in succinate dehydrogenase (SDH) subunits cause pheochromocytoma/paraganglioma (PCPG) an…
View article: A unique model for SDH-deficient GIST: an endocrine-related cancer
A unique model for SDH-deficient GIST: an endocrine-related cancer Open
We describe a unique patient-derived xenograft (PDX) and cell culture model of succinate dehydrogenase-deficient gastrointestinal stromal tumor (SDH-deficient GIST), a rare mesenchymal tumor that can occur in association with paraganglioma…