Inna Rozenberg
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View article: JIP4 and RILPL1 utilize opposing motor force to dynamically regulate lysosomal tubulation
JIP4 and RILPL1 utilize opposing motor force to dynamically regulate lysosomal tubulation Open
Lysosomes are dynamic organelles that remodel their membrane in response to stimuli. We previously uncovered a process we term LYsosomal Tubulation/sorting driven by LRRK2 (LYTL), wherein damaged lysosomes generate tubules sorted into vesi…
View article: Hexim1 heterozygosity stabilizes atherosclerotic plaque and decreased steatosis in ApoE null mice fed atherogenic diet
Hexim1 heterozygosity stabilizes atherosclerotic plaque and decreased steatosis in ApoE null mice fed atherogenic diet Open
Hexim-1 is an inhibitor of RNA polymerase II transcription elongation. Decreased Hexim-1 expression in animal models of chronic diseases such as left ventricular hypertrophy, obesity and cancer triggered significant changes in adaptation a…
View article: Hexim1, a Novel Regulator of Leptin Function, Modulates Obesity and Glucose Disposal
Hexim1, a Novel Regulator of Leptin Function, Modulates Obesity and Glucose Disposal Open
Leptin triggers signaling events with significant transcriptional responses that are essential to metabolic processes affecting obesity and glucose disposal. We asked whether hexamethylene bis-acetamide inducible-1 (Hexim1), an inhibitor o…