Explanipedia

Children with Recurrent Infections: Perspective of Immunoglobulin G Subclasses Deficiency and Impaired Specific Antibody Responses Open

Jalilah Jamaluddin, Siti Mardhiana Mohamad, Intan Hakimah Ismail · 2025

Children with recurrent infections present a diagnostic challenge due to the wide overlap between normal childhood infections and primary immunodeficiency diseases (PIDs). Predominantly antibody deficiencies (PADs) are the most common cate…

Antimicrobial activity of Malaysian Heterotrigona itama propolis against Enterococcus faecalis ATCC 4082: A study in endodontic applications Open

Adzzie Shazleen Azman, Rosharina Azian Hasirin, Hasnah Begum Said Gulam Khan, Z. Shafiei, Intan Hakimah Ismail · 2025

Reference Range for B-Cell Subpopulations in Peripheral Blood of Healthy Malaysian Children Aged 2 to 15 years. Open

Intan Hakimah Ismail, Jalilah Jamaluddin, Mohd Azri Zainal Abidin, Siti Mardhiana Mohamad, Hasni Mahayidin · 2025

Physicians rely on reference values from healthy populations to guide clinical decisions regarding B-cell subpopulations in primary immunodeficiency. While age-dependent reference ranges have been reported in several populations, no study …

Healthcare resources for inborn errors of immunity in the Asia-Pacific region Open

Motoi Yamashita, Yunfei An, Dharmagat Bhattarai, Vicky Wee Eng-Binas, Suravat Homvises , et al. · 2025

This questionnaire-based study provides insights into the current healthcare infrastructure used to diagnose and manage inborn errors of immunity across countries and regions involved in the Asia-Pacific Society for Immunodeficiencies.

A 19-year-old male with truncus arteriosus type I: a rare case report from Syria Open

Intan Hakimah Ismail, Abdulkader Bitar, Mouhammed Sleiay, M-Jaber Kojak, Molham Homsi , et al. · 2025

Introduction and importance: Truncus arteriosus type I is an uncommon congenital heart anomaly distinguished by the presence of a single arterial trunk emanating from the heart, resulting in the mixing of oxygenated and deoxygenated blood.…

Newborn screening for severe combined immunodeficiency in Malaysia: current status, challenges and progress Open

Wai Leng Chang, Lokman Mohd Noh, Amir Hamzah Abdul Latiff, Kent Chee Keen Woo, Intan Hakimah Ismail , et al. · 2024

Introduction Early diagnosis of Severe Combined Immunodeficiency (SCID) increases survival outcomes and quality of life while significantly minimizing healthcare burden and costs. Despite growing evidence supporting the benefits and cost-e…

Knowledge, awareness, and perception on genetic testing for primary immunodeficiency disease among parents in Malaysia: a qualitative study Open

Ahmad Hazim Syakir Ahmad Azahari, Farheen Hakim Zada, Intan Hakimah Ismail, Intan Juliana Abd Hamid, Bruce Wee Diong Lim , et al. · 2024

Background Primary Immunodeficiency Disease (PID), also known as Inborn Errors of Immunity (IEI), comprises a group of rare genetic disorders that impair the body’s immune responses. These conditions result from monogenic germline mutation…

Variants of<i>LYST</i>and Novel<i>STK4</i>Gene Mutation in a Child With Accelerated Chediak Higashi Syndrome Open

Asrar Abu Bakar, Haema Shunmugarajoo, Jeyaseelan P. Nachiappan, Intan Hakimah Ismail · 2024

Severe Combined Immunodeficiency in Malaysia: It’s Time to Shape a Future with No-One Left Behind Open

Intan Hakimah Ismail · 2023

Clinical features and mutational analysis of X-linked agammaglobulinemia patients in Malaysia Open

Chai Teng Chear, Intan Hakimah Ismail, Kwai Cheng Chan, Lokman Mohd Noh, Asiah Kassim , et al. · 2023

Background Bruton’s tyrosine kinase (BTK) is a cytoplasmic protein involved in the B cell development. X-linked agammaglobulinemia (XLA) is caused by mutation in the BTK gene, which results in very low or absent B cells. Affected males hav…

Transition practice for primary immunodeficiency diseases in Southeast Asia: a regional survey Open

Chee Mun Chan, Amir Hamzah Abdul Latiff, Lokman Mohd Noh, Intan Hakimah Ismail, Intan Juliana Abd Hamid , et al. · 2023

Introduction With increased diagnostic capabilities and treatment modalities in the field of primary immunodeficiencies (PID), many pediatric patients survive beyond childhood and experience a change of care to the adult-oriented healthcar…

The Antimicrobial Properties of Malaysian Propolis as Intracanal Medicament in Endodontics Open

Norsalsabila Mohd Rosli, N.A. Che Elliaziz, Fouad Al‐Bayaty, Intan Hakimah Ismail · 2023

Numerous studies have shown that propolis, from the sting and stingless bees, possessed antimicrobial, antifungal, antidiabetic, antitumoral and antioxidant properties. Propolis produced by stingless bees, Heterotrigona itama, also possess…

The Effectiveness of Early Food Introduction in Preventing Childhood Allergic Diseases: Protocol for a Systematic Review and Meta-Analysis Open

Aisha Fadhilah Abang Abdullah, Nor Asiah Muhamad, Rimah Melati Ab Ghani, Nur Hasnah Maamor, Fatin Norhasny Leman , et al. · 2023

Background Allergic diseases affect around 40% of the pediatric population worldwide. The coexistence of asthma, allergic rhinitis, eczema, and food allergy renders allergy treatment and prevention challenging. Infant feeding strategies re…

Health-Related Quality of Life of Patients and Families with Primary Immunodeficiency in Malaysia: a Cross-Sectional Study Open

Ruwaydah Ahmed Meelad, Intan Juliana Abd Hamid, Zarina Thasneem Zainudeen, Ilie Fadzilah Hashim, Muhd Nur Akmal Azizuddin , et al. · 2023

The Effectiveness of Early Food Introduction in Preventing Childhood Allergic Diseases: Protocol for a Systematic Review and Meta-Analysis (Preprint) Open

Aisha Fadhilah Abang Abdullah, Nor Asiah Muhamad, Rimah Melati Ab Ghani, Nur Hasnah Maamor, Fatin Norhasny Leman , et al. · 2023

BACKGROUND Allergic diseases affect around 40% of the pediatric population worldwide. The coexistence of asthma, allergic rhinitis, eczema, and food allergy renders allergy treatment and prevention challenging. Infant feeding strategies r…

A Novel De Novo NFKBIA Missense Mutation Associated to Ectodermal Dysplasia with Dysgammaglobulinemia Open

Chai Teng Chear, Bader Abdul Kader El Farran, Marina Sham, Kavetha Ramalingam, Lokman Mohd Noh , et al. · 2022

Background: Inborn errors of immunity (IEIs) are comprised of heterogeneous groups of genetic disorders affecting immune function. In this report, a 17-month-old Malay patient suspected of having Hyper IgM syndrome, a type of IEIs, was des…

In-vitro Comparison of Antibacterial Activities on Stingless Bee Propolis using Selected Extraction Methods Open

OHH Al-Masoodi, HB Said Gulam Khan, IH Baharuddin, Intan Hakimah Ismail · 2022

This study aimed to compare the different selected extraction methods of propolis extracts against Enterococcus faecalis (E. faecalis). Extraction of Malaysian Propolis (MP) from Heterotrigona itama, was carried out using 70% ethanol. For …

Pharmacological Management of Allergic Rhinitis: A Consensus Statement from the Malaysian Society of Allergy and Immunology Open

Baharudin Abdullah, Amir Hamzah Abdul Latiff, Ari Manuel, Faizah Mohamed Jamli, Harvinder Singh , et al. · 2022

The goal of allergic rhinitis (AR) management is to achieve satisfactory symptom control to ensure good quality of life. Most patients with AR are currently treated with pharmacotherapy. However, knowledge gaps on the use of pharmacotherap…

Targeted Gene Sanger Sequencing Should Remain the First-Tier Genetic Test for Children Suspected to Have the Five Common X-Linked Inborn Errors of Immunity Open

Koon-Wing Chan, Chung-Yin Wong, Daniel Leung, Xingtian Yang, Susanna F. S. Fok , et al. · 2022

To address inborn errors of immunity (IEI) which were underdiagnosed in resource-limited regions, our centre developed and offered free genetic testing for the most common IEI by Sanger sequencing (SS) since 2001. With the establishment of…

Editorial: Creating Awareness for Primary Immunodeficiencies in the Southeast and East Asia Regions Open

Intan Hakimah Ismail, Hirokazu Kanegane, Xiaodong Zhao · 2022

EDITORIAL article Front. Immunol., 11 May 2022Sec. Primary Immunodeficiencies Volume 13 - 2022 | https://doi.org/10.3389/fimmu.2022.920819

Impact of Primary Immunodeficiency Diseases on the Life Experiences of Patients in Malaysia From the Caregivers’ Perspective: A Qualitative Study Open

Ruwaydah Ahmed Meelad, Intan Juliana Abd Hamid, Ilie Fadzilah Hashim, Zarina Thasneem Zainudeen, Firdaus Farhani Abu Bakar , et al. · 2022

Introduction Primary immunodeficiency diseases (PIDs) are chronic diseases that affect the various aspects of a patient’s life. However, the impact of living with PIDs is poorly described. Objective This study aimed to explore the living e…

Ecthyma gangrenosum as a presenting feature of X-linked agammaglobulinemia: A case study Open

Intan Hakimah Ismail, Julia Adam · 2022

A previously healthy 5-year-old boy presented with symptoms of fever, vomiting, and diarrhea for three days. He had extensive erythematous skin lesions mainly over his bilateral lower limbs. His parents were nonconsanguineous, and his two …

Adaptation, Translation and Validation of the Food Allergy Quality of Life Questionnaire-Parent Form (FAQLQ-PF): The Malay Version Open

Izyana Syazlin Ibrahim, Noorhida Baharudin, Mohamad Rodi Isa, Intan Hakimah Ismail, Mohamed-Syarif Mohamed-Yassin , et al. · 2021

Food allergy has a significant impact on the quality of life (QoL) of children and can be measured using The Food Allergy Quality of Life Questionnaire-Parent Form (FAQLQ-PF). This study aimed to adapt, translate the FAQLQ-PF into Malay an…

Health-Related Quality of Life of Patients and Families with Primary Immunodeficiency in Malaysia: A Cross-Sectional Study Open

Ruwaydah Ahmed Meelad, Intan Juliana Abd Hamid, Zarina Thasneem Zainudeen, Ilie Fadzilah Hashim, Muhd Nur Akmal Azizuddin , et al. · 2021

Purpose: Primary immunodeficiency disease (PID) affects various aspects of a patient’s life. However, the health-related quality of life (HRQOL) of PID patients in Malaysia patients is poorly described. This study aimed to determine the qu…

Model to Aid Teaching of Electronic Apex Locator Use for Endodontics in Dental Pre-Clinical Training – A UiTM Experience Pilot Study Open

MA Berhanuddin, NF Mohamad, AA Ayoub, Mohd Asyran Safwan Kamaruzaman, IH Baharuddin , et al. · 2021

Background: Electronic Apex Locators (EAL) has been increasingly used to facilitate working length determination in endodontics. This instrument is becoming more important to be used in addition to radiographs. A steep learning curve has e…

Clinical and demographic pattern of chronic granulomatous disease (CGD) from a multicenter perspective: Malaysia’s experience over 26 years Open

Lokman Mohd Noh, Amir Hamzah Abdul Latiff, Intan Hakimah Ismail, Rahim Md Noah, Asrul Abdul Wahab , et al. · 2021

Clinical and Demographic Pattern of Chronic Granulomatous Disease (CGD) from a Multicenter Perspective: Malaysia’s Experience Over 26 Years Open

Lokman Mohd Noh, Amir Hamzah Abdul Latiff, Intan Hakimah Ismail, Rahim Md N, Asrul Abdul Wahab , et al. · 2021

Background:A retrospective review of clinical manifestations and demographic pattern of patients diagnosed as chronic granulomatous disease (CGD) from 7 hospitals in Malaysia.Methods: Data from the Malaysia Primary Immunodeficiency Network…

Maternal Vitamin D Levels during Late Pregnancy and Risk of Allergic Diseases and Sensitization during the First Year of Life—A Birth Cohort Study Open

Fui Chee Woon, Yit Siew Chin, Intan Hakimah Ismail, Amir Hamzah Abdul Latiff, Marijka Batterham , et al. · 2020

Allergic diseases are the most common chronic illness in childhood. Findings from developed countries have reported associations between Vitamin D levels during pregnancy and offspring allergy risk. This prospective cohort study aimed to d…

Anthropometry measurements to determine nutritional status among cerebral palsy children: a scoping review Open

Mahnon Suria Mokhy, Rosita Jamaluddin, Abd Rasyid Ismail, Woan Yie Siah, Norhasmah Sulaiman , et al. · 2020

This article aimed to review the available anthropometry measurements used in the assessment of nutritional status among Cerebral Palsy (CP) children. Searched journals were from Medline, PubMed and Ovid published from 2015 to 2018. The se…

Optimization of Protein Extraction Method for 2DE Proteomics of Goat’s Milk Open

Muzammeer Mansor, Jameel R. Al‐Obaidi, Nurain Nadiah Jaafar, Intan Hakimah Ismail, Atiqah Farah Zakaria , et al. · 2020

Two-dimensional electrophoretic (2DE)-based proteomics remains a powerful tool for allergenomic analysis of goat’s milk but requires effective extraction of proteins to accurately profile the overall causative allergens. However, there are…

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