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View article: Economic Impact of a Precision Nutrition Digital Therapeutic on Employer Health Costs: A Multi-Employer and Multi-Year Claims Analysis
Economic Impact of a Precision Nutrition Digital Therapeutic on Employer Health Costs: A Multi-Employer and Multi-Year Claims Analysis Open
Background: Obesity, gastrointestinal disorders, and mental health conditions are major drivers of employer healthcare expenditures, yet nutrition-focused interventions are infrequently reimbursed by health insurance. Precision nutrition, …
View article: Economic Impact of a Precision Nutrition Digital Therapeutic on Employer Health Costs: A Multi-Employer and Multi-Year Claims Analysis
Economic Impact of a Precision Nutrition Digital Therapeutic on Employer Health Costs: A Multi-Employer and Multi-Year Claims Analysis Open
Obesity, gastrointestinal disorders, and mental health conditions are major drivers of employer healthcare expenditures, yet nutrition-based interventions are rarely reimbursed by health insurance. Precision nutrition, which integrates gen…
View article: Interactions Between Gut Microbiome, Genetic Risk, and Obesity: Insights into Metabolic Pathways and Host-Microbe Dynamics
Interactions Between Gut Microbiome, Genetic Risk, and Obesity: Insights into Metabolic Pathways and Host-Microbe Dynamics Open
Background Obesity is a multifactorial metabolic disorder driven by genetic predisposition and gut microbiome composition, influencing key metabolic pathways through the gut-brain axis, gut-liver interactions, immune modulation, and insuli…
View article: Microbiome and Genetic Predictors of Weight Loss 12 Months Post Sleeve Gastrectomy: Insights from a Pilot Retrospective Cohort Study
Microbiome and Genetic Predictors of Weight Loss 12 Months Post Sleeve Gastrectomy: Insights from a Pilot Retrospective Cohort Study Open
Background Gut microbiome and genetic biomarkers are increasingly guiding obesity treatment. Bariatric surgery leads to shifts in gut microbial composition and function, while genome-wide association studies reveal genetic underpinnings of…
View article: Longitudinal gut microbial signals are associated with weight loss: insights from a digital therapeutics program
Longitudinal gut microbial signals are associated with weight loss: insights from a digital therapeutics program Open
Introduction The gut microbiome’s influence on weight management has gained significant interest for its potential to support better obesity therapeutics. Patient stratification leading to personalized nutritional intervention has shown be…
View article: Individualized Coexpression Network Strategies Employing Transcriptomic Data to Address Challenges in Stratification
Individualized Coexpression Network Strategies Employing Transcriptomic Data to Address Challenges in Stratification Open
The traditional network approach in gene expression analysis focuses on identifying relationships among gene expression patterns and associating them with metadata. In contrast, individualized coexpression networks offer a unique perspecti…
View article: Corrigendum: Unraveling patient heterogeneity in complex diseases through individualized co-expression networks: a perspective
Corrigendum: Unraveling patient heterogeneity in complex diseases through individualized co-expression networks: a perspective Open
[This corrects the article DOI: 10.3389/fgene.2023.1209416.].
View article: Unraveling patient heterogeneity in complex diseases through individualized co-expression networks: a perspective
Unraveling patient heterogeneity in complex diseases through individualized co-expression networks: a perspective Open
This perspective highlights the potential of individualized networks as a novel strategy for studying complex diseases through patient stratification, enabling advancements in precision medicine. We emphasize the impact of interpatient het…
View article: Longitudinal gut microbial signals are associated with weight loss: insights from a digital therapeutics program
Longitudinal gut microbial signals are associated with weight loss: insights from a digital therapeutics program Open
Obesity is a significant health problem due to its profound health deteriorating effects and high costs for healthcare systems. There exist lifestyle and pharmacological interventions available to prevent and reverse obesity; however, at t…
View article: Mental Health Symptom Reduction Using Digital Therapeutics Care Informed by Genomic SNPs and Gut Microbiome Signatures
Mental Health Symptom Reduction Using Digital Therapeutics Care Informed by Genomic SNPs and Gut Microbiome Signatures Open
Neuropsychiatric diseases and obesity are major components of morbidity and health care costs, with genetic, lifestyle, and gut microbiome factors linked to their etiology. Dietary and weight-loss interventions can help improve mental heal…
View article: Mental Health Symptom Reduction Using Digital Therapeutics Care Informed by Genomic SNPs and Gut Microbiome Signatures
Mental Health Symptom Reduction Using Digital Therapeutics Care Informed by Genomic SNPs and Gut Microbiome Signatures Open
Background Mental health diseases are a major component of morbidity and health care costs. Obesity and gut disorders are comorbid with mental health, with the gut microbiome hypothesized to play a key mechanistic role in linking them. Pha…
View article: Draft Genome Sequence of Bacillus safensis RP10, Isolated from Soil in the Atacama Desert, Chile
Draft Genome Sequence of Bacillus safensis RP10, Isolated from Soil in the Atacama Desert, Chile Open
Genome analysis of Bacillus safensis RP10, a strain from the soil of Atacama Desert in northern Chile, reflects a bacterium adapted to live in soil containing high levels of heavy metals, high salt conditions, and low carbon and energy sou…
View article: Initial Sequencing and Characterization of Gastrointestinal and Oral Microbiota in Urban Pakistani Adults Reveals Abnormally High Levels of Potentially Starch Metabolizing Bacteria in the General Population
Initial Sequencing and Characterization of Gastrointestinal and Oral Microbiota in Urban Pakistani Adults Reveals Abnormally High Levels of Potentially Starch Metabolizing Bacteria in the General Population Open
We describe the characterization of the gastrointestinal tract (gut) and oral microbiota (bacteria) in 32 urban Pakistani adults representing seven major geographies and six ethnicities in the country. Study participants were between ages …
View article: Neurogenomic Signatures of Successes and Failures in Life-History Transitions in a Key Insect Pollinator
Neurogenomic Signatures of Successes and Failures in Life-History Transitions in a Key Insect Pollinator Open
Life-history transitions require major reprogramming at the behavioral and physiological level. Mating and reproductive maturation are known to trigger changes in gene transcription in reproductive tissues in a wide range of organisms, but…
View article: FORGE: multivariate calculation of gene-wide p-values from Genome-Wide Association Studies Authors and Affiliations
FORGE: multivariate calculation of gene-wide p-values from Genome-Wide Association Studies Authors and Affiliations Open
Genome-wide association studies (GWAS) have proven a valuable tool to explore the genetic basis of many traits. However, many GWAS lack statistical power and the commonly used single-point analysis method needs to be complemented to enhanc…