Io Dolka
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View article: An Inducible and Reversible Mouse Genetic Rescue System
An Inducible and Reversible Mouse Genetic Rescue System Open
Inducible and reversible regulation of gene expression is a powerful approach for uncovering gene function. We have established a general method to efficiently produce reversible and inducible gene knockout and rescue in mice. In this syst…
View article: Large-scale, saturating insertional mutagenesis of the mouse genome
Large-scale, saturating insertional mutagenesis of the mouse genome Open
We describe the construction of a large-scale, orderly assembly of mutant ES cells, generated with retroviral insertions and having mutational coverage in >90% of mouse genes. We also describe a method for isolating ES cell clones with mut…