Ioana Cristina Marinaș
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View article: Piper nigrum Extract as an Adjuvant in a Collagen System for Infected Wound Healing: Therapeutic Synergy and Biocompatibility
Piper nigrum Extract as an Adjuvant in a Collagen System for Infected Wound Healing: Therapeutic Synergy and Biocompatibility Open
Background/Objectives: Natural plant-based compounds, especially black pepper extract, are known to have anti-inflammatory, antibacterial, and antioxidant qualities that promote procollagen formation and wound healing. This study focused o…
View article: Multifunctional protective strategies for wooden cultural heritage: antimicrobial efficacy of polyacrylic resins, siloxane coupling agents, and silver nanoparticles
Multifunctional protective strategies for wooden cultural heritage: antimicrobial efficacy of polyacrylic resins, siloxane coupling agents, and silver nanoparticles Open
Introduction This study evaluates two innovative protective treatments for wooden cultural heritage objects vulnerable to biodeterioration. The first involves polyacrylic resin solutions embedded with silver nanoparticles (AgNPs), while th…
View article: Piercing the future of vaccination: the revolutionary role of microneedle-based systems in healthcare advancements
Piercing the future of vaccination: the revolutionary role of microneedle-based systems in healthcare advancements Open
Microneedle (MNs)-based vaccine systems have emerged as a groundbreaking innovation in healthcare, presenting an alternative to conventional vaccine delivery approaches. This study provides an extensive review of the role of MNs in enhanci…
View article: Unlocking the potential of trifluoromethyl pyrrole derivatives in chronic wounds management: rapid synthesis, structural insights, and potent antimicrobial activity
Unlocking the potential of trifluoromethyl pyrrole derivatives in chronic wounds management: rapid synthesis, structural insights, and potent antimicrobial activity Open
Using a one-pot, three-component approach, we synthesised 25 dihydropyrrol-2-one and two 5-oxo-2,5-dihydrofuran compounds, each featuring two trifluoromethyl groups. This method emphasises timeliness and cost-effectiveness, crucial in drug…
View article: Review-Controlled Release of Essential Oils: Mechanisms, Biocompatibility, and Application Perspectives
Review-Controlled Release of Essential Oils: Mechanisms, Biocompatibility, and Application Perspectives Open
The efficient control of essential oils (EOs) active compounds release is essential, especially in pharmaceutical formulations, where the stability and bioavailability of active compounds are critical. The use of an encapsulation matrix wi…
View article: Antifungal and Antioxidant Activity of Thiourea Derivatives Against Nosocomial Candida auris Strains Isolated in Romania
Antifungal and Antioxidant Activity of Thiourea Derivatives Against Nosocomial Candida auris Strains Isolated in Romania Open
Nosocomial fungal infections caused by Candida auris pose a threat to public health due to their increased resistance to common antifungal drugs. Four thiourea derivatives of 2-thiophenecarboxylic acid were evaluated for their antifungal a…
View article: Copper Methacrylate Complexes with Benzimidazole Derivatives: Structural Characterization and Antimicrobial Assays
Copper Methacrylate Complexes with Benzimidazole Derivatives: Structural Characterization and Antimicrobial Assays Open
In order to design antimicrobial species, a series of methacrylate (Macr) complexes, [Cu(HBzIm)2(Macr)2] (1), [Cu2(HBzIm)2(Macr)4] (2), [Cu(2-MeBzIm)2(Macr)2] (3), [Cu2(2-MeBzIm)2(Macr)4] (4), and [Cu(5,6-Me2BzIm)2(Macr)2] (5) (HBzIm = ben…
View article: Postbiotic-Based Extracts from Native Probiotic Strains: A Promising Strategy for Food Preservation and Antimicrobial Defense
Postbiotic-Based Extracts from Native Probiotic Strains: A Promising Strategy for Food Preservation and Antimicrobial Defense Open
Background/Objectives: The deterioration of food quality and safety is often linked to the presence of pathogenic and spoilage microorganisms. Postbiotics, including organic acids, enzymes, and bacteriocins produced by lactic acid bacteria…
View article: Novel Buccal Xanthan Gum–Hyaluronic Acid Eutectogels with Dual Anti-Inflammatory and Antimicrobial Properties
Novel Buccal Xanthan Gum–Hyaluronic Acid Eutectogels with Dual Anti-Inflammatory and Antimicrobial Properties Open
Buccal drug delivery systems often struggle with poor drug solubility, limited adhesion, and rapid clearance, leading to suboptimal therapeutic outcomes. To address these limitations, we developed a novel hybrid eutectogel composed of xant…
View article: Complexes of Cd(II) with Nicotinamide, Nitrate, and Oxalate as Mixed Ligands: Synthesis, Characterization, and Biological Activity
Complexes of Cd(II) with Nicotinamide, Nitrate, and Oxalate as Mixed Ligands: Synthesis, Characterization, and Biological Activity Open
Three complexes of Cd(II), [Cd(NA)2(NO3)2(H2O)2] (1), [Cd(NA)2(NO3)2(H2O)2]·2NA (2), and [Cd(ox)(NA)(H2O)]·H2O (3) (NA = nicotinamide, ox = oxalate) were synthesized and characterized. Complexes (1) and (2) are mononuclear, while complex (…
View article: Emerging Resistance and Virulence Patterns in Salmonella enterica: Insights into Silver Nanoparticles as an Antimicrobial Strategy
Emerging Resistance and Virulence Patterns in Salmonella enterica: Insights into Silver Nanoparticles as an Antimicrobial Strategy Open
Background/Objectives: This study aims to characterize antibiotic resistance (AR) and virulence markers in Salmonella spp. isolated from Romanian outpatients’ stool samples. Methods: In 2019, community-acquired Salmonella strains were coll…
View article: Horticultural Plants and By-Products as Sources of Biological Active Compounds
Horticultural Plants and By-Products as Sources of Biological Active Compounds Open
Horticultural plants and their by-products from vegetable, herb and fruit cultivation, as well as from food industry operations, warehouses, and retail trade, are abundant in biologically active compounds such as polyphenols, flavonoids, c…
View article: Multi-shell gold nanoparticles functionalized with methotrexate: a novel nanotherapeutic approach for improved antitumoral and antioxidant activity and enhanced biocompatibility
Multi-shell gold nanoparticles functionalized with methotrexate: a novel nanotherapeutic approach for improved antitumoral and antioxidant activity and enhanced biocompatibility Open
Methotrexate (MTX) is a folic acid antagonist routinely used in cancer treatment, characterized by poor water solubility and low skin permeability. These issues could be mitigated by using drug delivery systems, such as functionalized gold…
View article: Phenotypic and Genotypic Characterization of Resistance and Virulence Markers in Candida spp. Isolated from Community-Acquired Infections in Bucharest, and the Impact of AgNPs on the Highly Resistant Isolates
Phenotypic and Genotypic Characterization of Resistance and Virulence Markers in Candida spp. Isolated from Community-Acquired Infections in Bucharest, and the Impact of AgNPs on the Highly Resistant Isolates Open
Background: This study aimed to determine, at the phenotypic and molecular levels, resistance and virulence markers in Candida spp. isolated from community-acquired infections in Bucharest outpatients during 2021, and to demonstrate the ef…
View article: Physico-Chemical Properties of Copper-Doped Hydroxyapatite Coatings Obtained by Vacuum Deposition Technique
Physico-Chemical Properties of Copper-Doped Hydroxyapatite Coatings Obtained by Vacuum Deposition Technique Open
The hydroxyapatite and copper-doped hydroxyapatite coatings (Ca10−xCux(PO4)6(OH)2; xCu = 0, 0.03; HAp and 3CuHAp) were obtained by the vacuum deposition technique. Then, both coatings were analyzed by the X-ray diffraction (XRD), scanning …
View article: Antioxidant, Antitumoral, Antimicrobial, and Prebiotic Activity of Magnetite Nanoparticles Loaded with Bee Pollen/Bee Bread Extracts and 5-Fluorouracil
Antioxidant, Antitumoral, Antimicrobial, and Prebiotic Activity of Magnetite Nanoparticles Loaded with Bee Pollen/Bee Bread Extracts and 5-Fluorouracil Open
The gut microbiota dysbiosis that often occurs in cancer therapy requires more efficient treatment options to be developed. In this concern, the present research approach is to develop drug delivery systems based on magnetite nanoparticles…
View article: Antimicrobial and Antioxidant Properties of Polyvinyl Alcohol Biocomposite Films Containing Ferulic Acid and Cellulose Extracted from <i>Robinia Pseudoacacia</i> Pods
Antimicrobial and Antioxidant Properties of Polyvinyl Alcohol Biocomposite Films Containing Ferulic Acid and Cellulose Extracted from <i>Robinia Pseudoacacia</i> Pods Open
Capitalizing on invasive plant species and stopping their aggressive spread might be achieved by using them as a renewable source of useful products such as cellulose. The study aimed to develop new cellulose-based food packaging materials…
View article: New Library of Iodo-Quinoline Derivatives Obtained by an Alternative Synthetic Pathway and Their Antimicrobial Activity
New Library of Iodo-Quinoline Derivatives Obtained by an Alternative Synthetic Pathway and Their Antimicrobial Activity Open
6-Iodo-substituted carboxy-quinolines were obtained using a one-pot, three-component method with trifluoroacetic acid as a catalyst under acidic conditions. Iodo-aniline, pyruvic acid and 22 phenyl-substituted aldehydes (we varied the type…
View article: Synthesis of New Zinc and Copper Coordination Polymers Derived from Bis (Triazole) Ligands
Synthesis of New Zinc and Copper Coordination Polymers Derived from Bis (Triazole) Ligands Open
Recent research has focused on molecules with different aromatic nitrogen-containing moieties coupled to a biphenyl core, as an effective approach for the assembly of coordination polymers. This study presents the synthesis and characteriz…
View article: Salvia officinalis–Hydroxyapatite Nanocomposites with Antibacterial Properties
Salvia officinalis–Hydroxyapatite Nanocomposites with Antibacterial Properties Open
In the present study, sage-coated zinc-doped hydroxyapatite was incorporated into a dextran matrix (7ZnHAp-SD), and its physico-chemical and antimicrobial activities were investigated. A 7ZnHAp-SD nanocomposite suspension was obtained usin…
View article: CCDC 2247119: Experimental Crystal Structure Determination
CCDC 2247119: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Contribution to the Synthesis, Characterization, Separation and Quantification of New N-Acyl Thiourea Derivatives with Antimicrobial and Antioxidant Potential
Contribution to the Synthesis, Characterization, Separation and Quantification of New N-Acyl Thiourea Derivatives with Antimicrobial and Antioxidant Potential Open
The present study aimed to synthesize, characterize, and validate a separation and quantification method of new N-acyl thiourea derivatives (1a–1o), incorporating thiazole or pyridine nucleus in the same molecule and showing antimicrobial …
View article: Alternative mitigating solutions based on inorganic nanoparticles for the preservation of cultural heritage
Alternative mitigating solutions based on inorganic nanoparticles for the preservation of cultural heritage Open
Introduction: Biodeterioration is a big challenge for the preservation of cultural heritage objects and for the community’s safety, fostering the search for novel methods effective in removing microbial biofilms and subsequent biodeteriora…
View article: Phenotypic and Genotypic Characterization of Recently Isolated Multidrug-Resistant Acinetobacter baumannii Clinical and Aquatic Strains and Demonstration of Silver Nanoparticle Potency
Phenotypic and Genotypic Characterization of Recently Isolated Multidrug-Resistant Acinetobacter baumannii Clinical and Aquatic Strains and Demonstration of Silver Nanoparticle Potency Open
This study aims to demonstrate the effectiveness of silver nanoparticles (Ag NPs) on multidrug-resistant (MDR) Acinetobacter baumannii (AB) strains isolated from the clinical and aquatic environment. Three types of Ag NPs were investigated…