Kalliopi Ioannidou
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View article: Bcl6 expression is associated with a distinct immune landscape and spatial transcriptome in COVID-19
Bcl6 expression is associated with a distinct immune landscape and spatial transcriptome in COVID-19 Open
The regulation of follicular (F) and germinal center (GC) immune reactivity in human lymph nodes (LNs), particularly during the acute stages of viral infection, remains poorly understood. We have analyzed lung-draining lymph nodes (LD-LNs)…
View article: Binding of RHOA G17V to p300 enhances its HAT activity: a new mechanism of epigenetic deregulation in TFH lymphoma
Binding of RHOA G17V to p300 enhances its HAT activity: a new mechanism of epigenetic deregulation in TFH lymphoma Open
The RHOA G17V mutation is highly recurrent in T follicular helper (TFH) cell lymphoma of the angioimmunoblastic type (AITL; 60%-70% of cases) and frequently associated with mutations in other T-cell receptor signaling genes, including CD28…
View article: Cellular and molecular determinants mediating the dysregulated germinal center immune dynamics in systemic lupus erythematosus
Cellular and molecular determinants mediating the dysregulated germinal center immune dynamics in systemic lupus erythematosus Open
Introduction Systemic lupus erythematosus (SLE) is characterized by dysregulated humoral immunity, leading to the generation of autoreactive B cells that can differentiate both within and outside of lymph node (LN) follicles. Methods Here,…
View article: Follicular Bcl6 reactivity is associated with a unique immune landscape and spatial transcriptome in COVID-19
Follicular Bcl6 reactivity is associated with a unique immune landscape and spatial transcriptome in COVID-19 Open
The regulation of follicular (F) and germinal center (GC) immune reactivity in human lymph nodes (LNs), particularly during the early stages of viral infections, remains poorly understood. We have analyzed lung-draining lymph nodes (LD-LNs…
View article: HIV infection is associated with compromised tumor microenvironment adaptive immune reactivity in Hodgkin lymphoma
HIV infection is associated with compromised tumor microenvironment adaptive immune reactivity in Hodgkin lymphoma Open
The impact of HIV infection on the tumor microenvironment (TME) of classic Hodgkin lymphoma (cHL), one of the most common comorbidities after HIV infection, is not well understood. Here, we have used multiplexed immunofluorescence and spat…
View article: PD1 inhibits PKCθ-dependent phosphorylation of cytoskeleton-related proteins and immune synapse formation
PD1 inhibits PKCθ-dependent phosphorylation of cytoskeleton-related proteins and immune synapse formation Open
The inhibitory surface receptor programmed cell death protein 1 (PD1) is a major target for antibody–based cancer immunotherapies. Nevertheless, a substantial number of patients fail to respond to the treatment or experience adverse effect…
View article: Multilevel human secondary lymphoid immune system compartmentalization revealed by complementary imaging approaches
Multilevel human secondary lymphoid immune system compartmentalization revealed by complementary imaging approaches Open
Secondary human lymphoid tissue immune reactions take place in a highly coordinated environment with compartmentalization representing a fundamental feature of this organization. In situ profiling methodologies are indispensable for…
View article: Multilevel human secondary lymphoid immune system compartmentalization revealed by complementary multiplexing and mass spectrometry imaging approaches
Multilevel human secondary lymphoid immune system compartmentalization revealed by complementary multiplexing and mass spectrometry imaging approaches Open
Secondary human lymphoid tissue immune reactions take place in a highly coordinated environment with compartmentalization representing a fundamental feature of this organization. In situ profiling methodologies are indispensable for the un…
View article: Addendum: Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma
Addendum: Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma Open
de la recherche sur l'être humain du canton de Vaud (CER-VD), in line with the legal requirements.Patients signed a general consent for use of health-related data.
View article: Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation
Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation Open
View article: Postmortem Cardiopulmonary Pathology in Patients with COVID-19 Infection: Single-Center Report of 12 Autopsies from Lausanne, Switzerland
Postmortem Cardiopulmonary Pathology in Patients with COVID-19 Infection: Single-Center Report of 12 Autopsies from Lausanne, Switzerland Open
We report postmortem cardio-pulmonary findings including detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in formalin-fixed paraffin embedded tissue in 12 patients with COVID-19. The 5 women and 7 men (median age: …
View article: Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma
Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma Open
Although tumor-associated lymphangiogenesis correlates with metastasis and poor prognosis in several cancers, it also supports T cell infiltration into the tumor and predicts favorable outcome to immunotherapy. The role of lymphatic vessel…
View article: Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer
Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer Open
Fully functional, tumor-specific, SLAMF7-expressing cytotoxic CD4 T cells directly mediate immunity against human cancer.
View article: In Situ Characterization of Follicular Helper CD4 T Cells Using Multiplexed Imaging
In Situ Characterization of Follicular Helper CD4 T Cells Using Multiplexed Imaging Open
Follicular helper CD4 T (Tfh) cells play an essential role in the formation of germinal centers (GCs), where mature B cells proliferate, differentiate, and provide long-term protective humoral responses. Despite the extensive phenotypic ch…
View article: 545 Tumor-specific cytolytic CD4 T cells mediate protective immunity against human cancer
545 Tumor-specific cytolytic CD4 T cells mediate protective immunity against human cancer Open
Background CD4 T cells have been implicated in cancer immunity for their helper functions. However, their direct cytotoxic potential remains elusive in cancer patients. Here, we aimed at assessing the presence, rate and cytotoxic function …
View article: Low Avidity T Cells Do Not Hinder High Avidity T Cell Responses Against Melanoma
Low Avidity T Cells Do Not Hinder High Avidity T Cell Responses Against Melanoma Open
The efficacy of T cells depends on their functional avidity, i. e., the strength of T cell interaction with cells presenting cognate antigen. The overall T cell response is composed of multiple T cell clonotypes, involving different T cell…
View article: Lymph node migratory dendritic cells modulate HIV-1 transcription through PD-1 engagement
Lymph node migratory dendritic cells modulate HIV-1 transcription through PD-1 engagement Open
T-follicular helper (Tfh) cells, co-expressing PD-1 and TIGIT, serve as a major cell reservoir for HIV-1 and are responsible for active and persistent HIV-1 transcription after prolonged antiretroviral therapy (ART). However, the precise m…
View article: Lymphatic vessel density is associated with CD8<sup>+</sup> T cell infiltration and immunosuppressive factors in human melanoma
Lymphatic vessel density is associated with CD8<sup>+</sup> T cell infiltration and immunosuppressive factors in human melanoma Open
Increased density of tumor-associated lymphatic vessels correlates with poor patient survival in melanoma and other cancers, yet lymphatic drainage is essential for initiating an immune response. Here we asked whether and how lymphatic ves…
View article: T cell–induced CSF1 promotes melanoma resistance to PD1 blockade
T cell–induced CSF1 promotes melanoma resistance to PD1 blockade Open
T cells promote immunosuppression in melanoma through CSF1 induction and macrophage recruitment.
View article: Immune Monitoring of Blood and Tumor Microenvironment
Immune Monitoring of Blood and Tumor Microenvironment Open
Immune responses can lead to treatment success in cancer patients. Tumor antigen-specific T cells play leading roles, and a large number of additional biological mechanisms can influence the clinical outcome. Monitoring immune responses in…
View article: Heterogeneity assessment of functional T cell avidity
Heterogeneity assessment of functional T cell avidity Open