Ioannis Anestopoulos
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View article: Transformative Bioactive Wear Resistant Ti <sub>3</sub> Au:N and Ti <sub>3</sub> Au:O Coatings for Medical Implants and Devices
Transformative Bioactive Wear Resistant Ti <sub>3</sub> Au:N and Ti <sub>3</sub> Au:O Coatings for Medical Implants and Devices Open
Current biomedical implants have high mechanical strength and corrosion resistance, but are highly susceptible to wear and lack antimicrobial properties to fight infection. Here, nitrogen and oxygen‐doped Ti 3 Au structures are successfull…
View article: Isothiocyanates Enhance the Anti-melanoma Effect of Entinostat Through Modulation of Apoptosis and HDACs’ Expression Patterns in an <i>In Vitro</i> Model of Human Malignant Melanoma
Isothiocyanates Enhance the Anti-melanoma Effect of Entinostat Through Modulation of Apoptosis and HDACs’ Expression Patterns in an <i>In Vitro</i> Model of Human Malignant Melanoma Open
We show evidence of an optimized experimental protocol capable of potentiating the anti-melanoma efficacy of ENT while maintaining a non-cytotoxic profile in non-tumorigenic cells.
View article: Precision depth-controlled isolated silver nanoparticle-doped diamond-like carbon coatings with enhanced ion release, biocompatibility, and mechanical performance
Precision depth-controlled isolated silver nanoparticle-doped diamond-like carbon coatings with enhanced ion release, biocompatibility, and mechanical performance Open
Silver doped diamond-like carbon (Ag/DLC) coatings are in high demand for biomedical applications such as artificial implants, surgical instruments, and medical devices. However, recent reports indicate that the excess Ag concentration req…
View article: Naturally-derived phenethyl isothiocyanate modulates apoptotic induction through regulation of the intrinsic cascade and resulting apoptosome formation in human malignant melanoma cells
Naturally-derived phenethyl isothiocyanate modulates apoptotic induction through regulation of the intrinsic cascade and resulting apoptosome formation in human malignant melanoma cells Open
Malignant melanoma is the most aggressive type of skin cancer with increasing incidence rates worldwide. On the other hand, watercress is a rich source of phenethyl isothiocyanate (PEITC), among others, which has been widely investigated f…
View article: Isothiocyanates Potentiate Tazemetostat-Induced Apoptosis by Modulating the Expression of Apoptotic Genes, Members of Polycomb Repressive Complex 2, and Levels of Tri-Methylating Lysine 27 at Histone 3 in Human Malignant Melanoma Cells
Isothiocyanates Potentiate Tazemetostat-Induced Apoptosis by Modulating the Expression of Apoptotic Genes, Members of Polycomb Repressive Complex 2, and Levels of Tri-Methylating Lysine 27 at Histone 3 in Human Malignant Melanoma Cells Open
In this study, we utilized an in vitro model consisting of human malignant melanoma as well as non-tumorigenic immortalized keratinocyte cells with the aim of characterizing the therapeutic effectiveness of the clinical epigenetic drug Taz…
View article: Biomechanical characteristics of silver enriched diamond-like carbon coatings for medical applications
Biomechanical characteristics of silver enriched diamond-like carbon coatings for medical applications Open
Silver enriched diamond-like carbon (Ag/DLC) coatings are gaining a reputation for medical applications as Ag doping improves the intrinsic biocompatibility and antimicrobial features of DLC, and higher Ag amounts improve its hemocompatibi…
View article: Multi-method biophysical analysis in discovery, identification, and in-depth characterization of surface‐active compounds
Multi-method biophysical analysis in discovery, identification, and in-depth characterization of surface‐active compounds Open
Synthetic surfactants are used in several industries, including manufacturing, pharmaceutical and cosmetic’s, food and feed, agriculture, petroleum and environmental remediation for their ability to adsorb to fluid and solid-water interfac…
View article: Expression of CD47 and SIRPα Macrophage Immune-Checkpoint Pathway in Non-Small-Cell Lung Cancer
Expression of CD47 and SIRPα Macrophage Immune-Checkpoint Pathway in Non-Small-Cell Lung Cancer Open
Background: Cancer cells escape macrophage phagocytosis by expressing the CD47 integrin-associated protein that binds to the SIRPα ligand (signal regulatory protein alpha) expressed by macrophages. Immunotherapy targeting this pathway is u…
View article: Cereal and Confectionary Packaging: Background, Application and Shelf-Life Extension
Cereal and Confectionary Packaging: Background, Application and Shelf-Life Extension Open
In both public and private sectors, one can notice a strong interest in the topic of sustainable food and packaging. For a long time, the spotlight for optimization was placed on well-known examples of high environmental impacts, whether r…
View article: Evaluation of Bioactive Properties of Lipophilic Fractions of Edible and Non-Edible Parts of Nasturtium officinale (Watercress) in a Model of Human Malignant Melanoma Cells
Evaluation of Bioactive Properties of Lipophilic Fractions of Edible and Non-Edible Parts of Nasturtium officinale (Watercress) in a Model of Human Malignant Melanoma Cells Open
Watercress is an enriched source of phenethyl isothiocyanate (PEITC), among other phytochemicals, with an antioxidant capacity. The aim of this study was to (i) chemically characterize and (ii) biologically evaluate the profile of the main…
View article: Targeting the Epigenome in Malignant Melanoma: Facts, Challenges and Therapeutic Promises
Targeting the Epigenome in Malignant Melanoma: Facts, Challenges and Therapeutic Promises Open
View article: Chemical and Biological Characterization of the Anticancer Potency of Salvia fruticosa in a Model of Human Malignant Melanoma
Chemical and Biological Characterization of the Anticancer Potency of Salvia fruticosa in a Model of Human Malignant Melanoma Open
Malignant melanoma is one of the most aggressive types of skin cancer with an increasing incidence worldwide. Thus, the development of innovative therapeutic approaches is of great importance. Salvia fruticosa (SF) is known for its antican…
View article: A novel methylated analogue of L-Mimosine exerts its therapeutic potency through ROS production and ceramide-induced apoptosis in malignant melanoma
A novel methylated analogue of L-Mimosine exerts its therapeutic potency through ROS production and ceramide-induced apoptosis in malignant melanoma Open
View article: A novel methylated analogue of L-Mimosine exerts its therapeutic potency through ROS production and ceramide-induced apoptosis in malignant melanoma
A novel methylated analogue of L-Mimosine exerts its therapeutic potency through ROS production and ceramide-induced apoptosis in malignant melanoma Open
Melanoma is an aggressive and highly metastatic type of skin cancer where the design of new therapies is of utmost importance for the clinical management of the disease. Thus, we have aimed to investigate the mode of action by which a nove…
View article: An Evaluation of the Anti-Carcinogenic Response of Major Isothiocyanates in Non-Metastatic and Metastatic Melanoma Cells
An Evaluation of the Anti-Carcinogenic Response of Major Isothiocyanates in Non-Metastatic and Metastatic Melanoma Cells Open
Malignant melanoma is one of the most deadly types of solid cancers, a property mainly attributed to its highly aggressive metastatic form. On the other hand, different classes of isothiocyanates, a class of phytochemicals, present in cruc…
View article: The anticancer potential of silibinin is associated with alterations in gene expression levels of major epigenetic enzymes in prostate carcinoma
The anticancer potential of silibinin is associated with alterations in gene expression levels of major epigenetic enzymes in prostate carcinoma Open
Silibinin, a diastereoisomeric mixture extracted from Silybum marianum L, with established anti-prostate cancer activity, has been associated with considerable anti-neoplastic ability, in a variety of human cancer types, through interferen…
View article: Isothiocyanate-induced Cell Cycle Arrest in a Novel<i>In Vitro</i>Exposure Protocol of Human Malignant Melanoma (A375) Cells
Isothiocyanate-induced Cell Cycle Arrest in a Novel<i>In Vitro</i>Exposure Protocol of Human Malignant Melanoma (A375) Cells Open
ITCs induced cell-cycle arrest in A375 cells.
View article: Hyperthermia induces therapeutic effectiveness and potentiates adjuvant therapy with non-targeted and targeted drugs in an in vitro model of human malignant melanoma
Hyperthermia induces therapeutic effectiveness and potentiates adjuvant therapy with non-targeted and targeted drugs in an in vitro model of human malignant melanoma Open
View article: A Novel Role of Silibinin as a Putative Epigenetic Modulator in Human Prostate Carcinoma
A Novel Role of Silibinin as a Putative Epigenetic Modulator in Human Prostate Carcinoma Open
Silibinin, extracted from milk thistle (Silybum marianum L.), has exhibited considerable preclinical activity against prostate carcinoma. Its antitumor and chemopreventive activities have been associated with diverse effects on cell cycle,…
View article: Development of a Novel Experimental In Vitro Model of Isothiocyanate-induced Apoptosis in Human Malignant Melanoma Cells
Development of a Novel Experimental In Vitro Model of Isothiocyanate-induced Apoptosis in Human Malignant Melanoma Cells Open
Utilization of low isothiocyanate concentrations (under the conditions described herein) exerts an anti-cancer effect specific to human malignant melanoma cells thus providing a therapeutic basis for their utilization in management of the …
View article: Antioxidant and Antiproliferative Properties of the Essential Oils of Satureja thymbra and Satureja parnassica and their Major Constituents
Antioxidant and Antiproliferative Properties of the Essential Oils of Satureja thymbra and Satureja parnassica and their Major Constituents Open
S. thymbra and S. parnassica essential oils exhibit significant but diverse antioxidant and antiproliferative activities, mainly attributed to their main components, carvacrol and thymol.