Ioannis Christodoulou
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View article: Living Labs as Ethical Spaces: Fostering Innovation and Sustainability in Food Systems
Living Labs as Ethical Spaces: Fostering Innovation and Sustainability in Food Systems Open
We examine the role of living labs as ethical spaces in driving sustainability transitions in food systems through participatory experimentation, stakeholder engagement, and knowledge exchange. We conceptualise living labs as dynamic envir…
View article: miRNA-Guided Regulation of Mesenchymal Stem Cells Derived from the Umbilical Cord: Paving the Way for Stem-Cell Based Regeneration and Therapy
miRNA-Guided Regulation of Mesenchymal Stem Cells Derived from the Umbilical Cord: Paving the Way for Stem-Cell Based Regeneration and Therapy Open
The human body is an abundant source of multipotent cells primed with unique properties that can be exploited in a multitude of applications and interventions. Mesenchymal stem cells (MSCs) represent a heterogenous population of undifferen…
View article: Real world data from a multi-centre study on the effects of cilostazol on pain symptoms and walking distance in patients with peripheral arterial disease
Real world data from a multi-centre study on the effects of cilostazol on pain symptoms and walking distance in patients with peripheral arterial disease Open
Objective to assess the effects of cilostazol on pain-free walking distance in PAD patients with IC at 3 and 6 months in a real world, prospective, observational study. We included 1015 PAD patients presenting with IC (71.3% men, 93.5% whi…
View article: Suitability of Human Mesenchymal Stem Cells Derived from Fetal Umbilical Cord (Wharton’s Jelly) as an Alternative In Vitro Model for Acute Drug Toxicity Screening
Suitability of Human Mesenchymal Stem Cells Derived from Fetal Umbilical Cord (Wharton’s Jelly) as an Alternative In Vitro Model for Acute Drug Toxicity Screening Open
Preclinical toxicity screening is the first and most crucial test that assesses the safety of new candidate drugs before their consideration for further evaluation in clinical trials. In vitro drug screening using stem cells has lately ari…
View article: Protective role of taurine against oxidative stress (Review)
Protective role of taurine against oxidative stress (Review) Open
Taurine is a fundamental mediator of homeostasis that exerts multiple roles to confer protection against oxidant stress. The development of hypertension, muscle/neuro‑associated disorders, hepatic cirrhosis, cardiac dysfunction and ischem…
View article: Ameliorative effect of taurine against diabetes and renal‑associated disorders (Review)
Ameliorative effect of taurine against diabetes and renal‑associated disorders (Review) Open
To develop novel therapeutic methods for both diabetic and renal disorders, scientists had initially focused on elucidating the molecular mechanisms of taurine in established cell lines and mouse models. Although a large amount of data hav…
View article: Potential Relationship Between Lifestyle Changes and Incidence of Hospital Admissions for Acute Coronary Syndrome During the COVID-19 Lockdown
Potential Relationship Between Lifestyle Changes and Incidence of Hospital Admissions for Acute Coronary Syndrome During the COVID-19 Lockdown Open
Aims: To evaluate the impact of lockdown during the COVID-19 pandemic on lifestyle changes of the general population, and on admissions for acute coronary syndrome (ACS). Methods and Results: All ACS admissions during the COVID-19 lockdown…
View article: Of numbers and movement – understanding transcription factor pathogenesis by advanced microscopy
Of numbers and movement – understanding transcription factor pathogenesis by advanced microscopy Open
Transcription factors (TFs) are life-sustaining and, therefore, the subject of intensive research. By regulating gene expression, TFs control a plethora of developmental and physiological processes, and their abnormal function commonly lea…
View article: Developmental Regulation of Mitotic Chromosome Formation Revealed by Condensin Reporter Mice
Developmental Regulation of Mitotic Chromosome Formation Revealed by Condensin Reporter Mice Open
Withdrawal Note: The authors have withdrawn their manuscript due to the discovery of artifacts that call into question key findings from the study. Both artifacts originate from cell-type differences that arose during sample processing, cr…
View article: Yorkie controls tube length and apical barrier integrity during airway development
Yorkie controls tube length and apical barrier integrity during airway development Open
Epithelial organ size and shape depend on cell shape changes, cell–matrix communication, and apical membrane growth. The Drosophila melanogaster embryonic tracheal network is an excellent model to study these processes. Here, we show that …
View article: Mesenchymal stem cells in preclinical cancer cytotherapy: a systematic review
Mesenchymal stem cells in preclinical cancer cytotherapy: a systematic review Open
Mesenchymal stem cells (MSC) comprise a heterogeneous population of rapidly proliferating cells that can be isolated from adult (e.g., bone marrow, adipose tissue) as well as fetal (e.g., umbilical cord) tissues (termed bone marrow (BM)-, …
View article: CRISPR therapeutic tools for complex genetic disorders and cancer (Review)
CRISPR therapeutic tools for complex genetic disorders and cancer (Review) Open
One of the fundamental discoveries in the field of biology is the ability to modulate the genome and to monitor the functional outputs derived from genomic alterations. In order to unravel new therapeutic options, scientists had initially …
View article: Genetically‑modified stem cells in treatment of human diseases: Tissue kallikrein (KLK1)‑based targeted therapy (Review)
Genetically‑modified stem cells in treatment of human diseases: Tissue kallikrein (KLK1)‑based targeted therapy (Review) Open
The tissue kallikrein‑kinin system (KKS) is an endogenous multiprotein metabolic cascade which is implicated in the homeostasis of the cardiovascular, renal and central nervous system. Human tissue kallikrein (KLK1) is a serine protease, c…
View article: Role of the CRISPR system in controlling gene transcription and monitoring cell fate (Review)
Role of the CRISPR system in controlling gene transcription and monitoring cell fate (Review) Open
Even though the accrual of transcripts is implicated in distinct disease states, our knowledge regarding their functional role remains obscure. The CRISPR system has surged at the forefront of genome engineering tools in the field of RNA m…