Ioannis Kienes
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View article: NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARγ target genes
NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARγ target genes Open
View article: Bacterial subversion of NLR-mediated immune responses
Bacterial subversion of NLR-mediated immune responses Open
Members of the mammalian Nod-like receptor (NLR) protein family are important intracellular sensors for bacteria. Bacteria have evolved under the pressure of detection by host immune sensing systems, leading to adaptive subversion strategi…
View article: 14-3-3 and erlin proteins differentially interact with RIPK2 complexes
14-3-3 and erlin proteins differentially interact with RIPK2 complexes Open
The receptor interacting serine/threonine kinase 2 (RIPK2) is essential for signal transduction induced by the pattern recognition receptors NOD1 and NOD2 (referred to collectively as NOD1/2). Upon NOD1/2 activation, RIPK2 forms complexes …
View article: DDX3X Links NLRP11 to the Regulation of Type I Interferon Responses and NLRP3 Inflammasome Activation
DDX3X Links NLRP11 to the Regulation of Type I Interferon Responses and NLRP3 Inflammasome Activation Open
Tight regulation of inflammatory cytokine and interferon (IFN) production in innate immunity is pivotal for optimal control of pathogens and avoidance of immunopathology. The human Nod-like receptor (NLR) NLRP11 has been shown to regulate …
View article: Role of NLRs in the Regulation of Type I Interferon Signaling, Host Defense and Tolerance to Inflammation
Role of NLRs in the Regulation of Type I Interferon Signaling, Host Defense and Tolerance to Inflammation Open
Type I interferon signaling contributes to the development of innate and adaptive immune responses to either viruses, fungi, or bacteria. However, amplitude and timing of the interferon response is of utmost importance for preventing an un…
View article: XIAP controls RIPK2 signaling by preventing its deposition in speck-like structures
XIAP controls RIPK2 signaling by preventing its deposition in speck-like structures Open
The receptor interacting serine/threonine kinase 2 (RIPK2) is essential for linking activation of the pattern recognition receptors NOD1 and NOD2 to cellular signaling events. Recently, it was shown that RIPK2 can form higher order molecul…
View article: XIAP controls RIPK2 signaling by preventing its deposition in speck-like structures
XIAP controls RIPK2 signaling by preventing its deposition in speck-like structures Open
The receptor interacting serine/threonine kinase 2 (RIPK2) is essential for linking activation of the pattern recognition receptors NOD1 and NOD2 to cellular signaling events. Recently, it was shown that RIPK2 forms higher order molecular …
View article: The NLR family pyrin domain–containing 11 protein contributes to the regulation of inflammatory signaling
The NLR family pyrin domain–containing 11 protein contributes to the regulation of inflammatory signaling Open
Mammalian Nod-like receptor (NLR) proteins contribute to the regulation and induction of innate and adaptive immunity in mammals, although the function of about half of the currently identified NLR proteins remains poorly characterized. He…