Ioannis Kyriakidis
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View article: Health-Related Quality of Life and Social Outcomes in Adolescents and Young Adult Survivors of Childhood Cancer: A Single-Center Case–Control Study from Crete, Greece
Health-Related Quality of Life and Social Outcomes in Adolescents and Young Adult Survivors of Childhood Cancer: A Single-Center Case–Control Study from Crete, Greece Open
Background: Recent advances in childhood cancer treatment and increased survival rates have led to a growing number of adolescents and young adults (AYAs) who are survivors of childhood cancer (CCSs). This study aimed to examine health sta…
View article: AutoML identification of microRNA biomarkers in high-risk pediatric acute lymphoblastic leukemia
AutoML identification of microRNA biomarkers in high-risk pediatric acute lymphoblastic leukemia Open
Despite significant advancements in overall survival rates for childhood acute lymphoblastic leukemia (ALL), relapse continues to pose a major challenge. MicroRNAs have proven valuable for improving diagnosis, treatment, and survival outco…
View article: Association of DROSHA Variants with Susceptibility and Outcomes in Childhood Acute Lymphoblastic Leukemia
Association of DROSHA Variants with Susceptibility and Outcomes in Childhood Acute Lymphoblastic Leukemia Open
MicroRNAs are key regulators of lymphoid differentiation, exhibiting a pivotal role in acute lymphoblastic leukemia (ALL) biology and prognosis. The initial steps of canonical miRNA biogenesis involve the microprocessor complex processing …
View article: Pre-analytical considerations for microRNA quantification in childhood leukemia research
Pre-analytical considerations for microRNA quantification in childhood leukemia research Open
Background: MicroRNAs (miRNAs) have gained significant attention as potential biomarkers in childhood leukemia, offering insights into diagnosis, prognosis, and therapeutic targeting. However, the clinical translation of miRNA biomarkers f…
View article: Approach to Macrodactyly: A Case Report and Diagnostic Algorithm for Syndromic and Isolated Forms
Approach to Macrodactyly: A Case Report and Diagnostic Algorithm for Syndromic and Isolated Forms Open
Background: Macrodactyly (megalodactyly or digital gigantism) is a rare condition of overgrowth affecting one or more fingers or toes. Methods: We report a case of a 16-year-old Caucasian male with macrodactyly, lipomas, nevi, dysmorphic f…
View article: Epidemiology of Invasive Fungal Diseases: A 10-Year Experience in a Tertiary Pediatric Hematology–Oncology Department in Greece
Epidemiology of Invasive Fungal Diseases: A 10-Year Experience in a Tertiary Pediatric Hematology–Oncology Department in Greece Open
Although advances in the management of pediatric neoplasms have profoundly improved infectious disease outcomes, invasive fungal diseases (IFDs) remain a major cause of morbidity and mortality in children and adolescents with high-risk hem…
View article: Central Line-Associated Bloodstream Infection Due to Elizabethkingia anophelis: Case Report and Literature Review on Pediatric Infections
Central Line-Associated Bloodstream Infection Due to Elizabethkingia anophelis: Case Report and Literature Review on Pediatric Infections Open
Elizabethkingia anophelis is an opportunistic pathogen causing lifethreatening infections in humans, particularly in immunocompromised patients, neonates and the elderly. We report a case of central line-associated bloodstream infection by…
View article: B–NHL Cases in a Tertiary Pediatric Hematology—Oncology Department: A 20-Year Retrospective Cohort Study
B–NHL Cases in a Tertiary Pediatric Hematology—Oncology Department: A 20-Year Retrospective Cohort Study Open
Non-Hodgkin lymphoma (NHL) is among the five most common pediatric cancer diagnoses in children and adolescents and consists of a heterogeneous group of lymphoid tissue malignancies –with B-cell-derived NHL accounting for nearly 80% of cas…
View article: Central Line-Associated Bloodstream Infection Due to Elizabethkingia anophelis: Case Report and Literature Review on Pediatric Infections
Central Line-Associated Bloodstream Infection Due to Elizabethkingia anophelis: Case Report and Literature Review on Pediatric Infections Open
Elizabethkingia anophelis is an opportunistic pathogen causing lifethreatening infections in humans, particularly in immunocompromised patients, neonates and elderly. Infections caused by this species are exceptionally challenging to treat…
View article: The Diverse Genomic Landscape of Diamond–Blackfan Anemia: Two Novel Variants and a Mini-Review
The Diverse Genomic Landscape of Diamond–Blackfan Anemia: Two Novel Variants and a Mini-Review Open
Diamond–Blackfan anemia (DBA) is a ribosomopathy characterized by bone marrow erythroid hypoplasia, which typically presents with severe anemia within the first months of life. DBA is typically attributed to a heterozygous mutation in a ri…
View article: Infectious Complications of Targeted Therapies in Children with Leukemias and Lymphomas
Infectious Complications of Targeted Therapies in Children with Leukemias and Lymphomas Open
The aim of this review is to highlight mechanisms of immunosuppression for each agent, along with pooled analyses of infectious complications from the available medical literature. Rituximab confers no increase in grade ≥3 infectious risks…
View article: MicroRNAs and the Diagnosis of Childhood Acute Lymphoblastic Leukemia: Systematic Review, Meta-Analysis and Re-Analysis with Novel Small RNA-Seq Tools
MicroRNAs and the Diagnosis of Childhood Acute Lymphoblastic Leukemia: Systematic Review, Meta-Analysis and Re-Analysis with Novel Small RNA-Seq Tools Open
MicroRNAs (miRNAs) have been implicated in childhood acute lymphoblastic leukemia (ALL) pathogenesis. We performed a systematic review and meta-analysis of miRNA single-nucleotide polymorphisms (SNPs) in childhood ALL compared with healthy…
View article: MicroRNAs and the diagnosis of childhood acute lymphoblastic leukemia: systematic review, meta-analysis and re-analysis with novel SmallRNA-seq tools
MicroRNAs and the diagnosis of childhood acute lymphoblastic leukemia: systematic review, meta-analysis and re-analysis with novel SmallRNA-seq tools Open
MicroRNAs (miRNAs) have been under the spotlight during the last three dec- 17 ades. These non-coding RNAs seem to be dynamic regulators of mRNA stability and translation, 18 while they seem to interfere with transcription as well. Circula…
View article: Acinetobacter baumannii Antibiotic Resistance Mechanisms
Acinetobacter baumannii Antibiotic Resistance Mechanisms Open
Acinetobacter baumannii is a Gram-negative ESKAPE microorganism that poses a threat to public health by causing severe and invasive (mostly nosocomial) infections linked with high mortality rates. During the last years, this pathogen displ…
View article: Invasive Fungal Diseases in Children with Hematological Malignancies Treated with Therapies That Target Cell Surface Antigens: Monoclonal Antibodies, Immune Checkpoint Inhibitors and CAR T-Cell Therapies
Invasive Fungal Diseases in Children with Hematological Malignancies Treated with Therapies That Target Cell Surface Antigens: Monoclonal Antibodies, Immune Checkpoint Inhibitors and CAR T-Cell Therapies Open
Since 1985 when the first agent targeting antigens on the surface of lymphocytes was approved (muromonab-CD3), a multitude of such therapies have been used in children with hematologic malignancies. A detailed literature review until Janua…
View article: Data regarding 2D:4D and other digit ratios in Greek population
Data regarding 2D:4D and other digit ratios in Greek population Open
View article: Hemoglobinopatisi olan bir bebekte biliyer atrezi komplikasyonu olarak kandidemi
Hemoglobinopatisi olan bir bebekte biliyer atrezi komplikasyonu olarak kandidemi Open
Both biliary atresia and hemoglobinopathies have been associated with a higher incidence of bloodstream infections. We hereby present the case of a female infant of Nigerian descent with extrahepatic biliary atresia and double heterozygoci…
View article: Extrahepatic biliary atresia, liver function tests, and hemoglobin variants
Extrahepatic biliary atresia, liver function tests, and hemoglobin variants Open
View article: Primary EBV infection and hypersensitivity to mosquito bites: a case report
Primary EBV infection and hypersensitivity to mosquito bites: a case report Open
View article: A Generic Preprocessing Optimization Methodology when Predicting Time-Series Data
A Generic Preprocessing Optimization Methodology when Predicting Time-Series Data Open
A general Methodology referred to as Daphne is introduced which is used to find optimum combinations of methods to preprocess and forecast for time-series datasets. The Daphne Optimization Methodology (DOM) is based on the idea of quantify…
View article: Lumbar puncture complicated by spinal epidural hematoma in a child with leukemia
Lumbar puncture complicated by spinal epidural hematoma in a child with leukemia Open
Key Clinical Message We report a case of spinal epidural hematoma ( SEH ) preceded by diagnostic lumbar puncture ( LP ) in a 5‐year‐old boy with acute lymphoblastic leukemia. MRI confirmed the presence of SEH between T7 and L5 levels, but …
View article: Bilateral eyelid ptosis, attributed to vincristine, treated successfully with pyridoxine and thiamine in a child with acute lymphoblastic leukemia
Bilateral eyelid ptosis, attributed to vincristine, treated successfully with pyridoxine and thiamine in a child with acute lymphoblastic leukemia Open
Vincristine-induced neurotoxicity is an adverse effect commonly seen in pediatric patients treated for cancer. We hereby present a case of a 6-year-old boy with acute lymphoblastic leukemia, who developed bilateral eyelid ptosis 25 days af…