Iokfai Cheang
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View article: The association of serum GDF-15 level with the improvement of left ventricular ejection fraction in patients with heart failure and reduced ejection fraction
The association of serum GDF-15 level with the improvement of left ventricular ejection fraction in patients with heart failure and reduced ejection fraction Open
Background: Heart failure with improved ejection fraction (HFimpEF) is a distinct subtype of heart failure. Growth differentiation factor-15 (GDF-15), a biomarker linked to adverse cardiovascular outcomes, could help predict left ventricul…
View article: Prognostic Significance of Cardiac Output in Postcapillary Pulmonary Hypertension: Estimated Fick vs. Thermodilution
Prognostic Significance of Cardiac Output in Postcapillary Pulmonary Hypertension: Estimated Fick vs. Thermodilution Open
Background: The prognostic value of cardiac output measured by the estimated Fick method and thermodilution in patients with postcapillary pulmonary hypertension (pc-PH) is unclear. We aimed to compare the correlations and consistency of c…
View article: Impacts of COPD exacerbation history on mortality and severe cardiovascular events among patients with COPD in China: a retrospective cohort study
Impacts of COPD exacerbation history on mortality and severe cardiovascular events among patients with COPD in China: a retrospective cohort study Open
View article: Cardiovascular risks associated with adjuvant endocrine therapy in women with breast cancer: a population-based cohort study
Cardiovascular risks associated with adjuvant endocrine therapy in women with breast cancer: a population-based cohort study Open
View article: Treatment Patterns and Triple Therapy Utilization in Chinese Patients with Chronic Obstructive Pulmonary Disease: An Analysis of Real-World Data from the Yinzhou Database
Treatment Patterns and Triple Therapy Utilization in Chinese Patients with Chronic Obstructive Pulmonary Disease: An Analysis of Real-World Data from the Yinzhou Database Open
Our study assessed treatment patterns and triple therapy utilization among patients with COPD in China. The majority of patients were treated with ICS+LABA dual therapy. Triple therapy was also widely used, with most patients transitioning…
View article: Interaction of Body Mass Index and Glycemic Status on Cardiovascular Outcomes in Patients With Cancer Treated With Anthracyclines
Interaction of Body Mass Index and Glycemic Status on Cardiovascular Outcomes in Patients With Cancer Treated With Anthracyclines Open
Background Anthracycline‐based chemotherapy is a vital treatment for various cancers but carries notable risks of cardiotoxicity. This study aimed to assess how different body mass index values and glycemic status influence the risk of maj…
View article: Comparative Discrimination of Life’s Simple 7, Life’s Essential 8, and Life’s Crucial 9: Evaluating the impact of added complexity on mortality prediction
Comparative Discrimination of Life’s Simple 7, Life’s Essential 8, and Life’s Crucial 9: Evaluating the impact of added complexity on mortality prediction Open
View article: Macrophage <scp>A2aR</scp> Alleviates <scp>LPS</scp>‐Induced Vascular Endothelial Injury and Inflammation via Inhibiting <scp>M1</scp> Polarisation and Oxidative Stress
Macrophage <span>A2aR</span> Alleviates <span>LPS</span>‐Induced Vascular Endothelial Injury and Inflammation via Inhibiting <span>M1</span> Polarisation and Oxidative Stress Open
Vascular inflammation and endothelial dysfunction secondary to unchecked activation of endothelium are key mechanisms underlying sepsis and organ failure. However, the intrinsic processes that mitigate excessive endothelial cell activation…
View article: Current Understanding and Evidence Regarding Qiliqiangxin (QLQX) in Heart Failure Treatment: From Basic to Clinical Research
Current Understanding and Evidence Regarding Qiliqiangxin (QLQX) in Heart Failure Treatment: From Basic to Clinical Research Open
Qiliqiangxin (QLQX), a traditional Chinese medicine (TCM) formulation, has shown therapeutic potential in heart failure (HF) through its multifaceted mechanisms. This review synthesizes preclinical and clinical evidence, highlighting the a…
View article: Prognosis Prediction of Cardiovascular Event With Glucose‐Albumin Ratio on Patients With Cancer and Prescribed With Anthracycline
Prognosis Prediction of Cardiovascular Event With Glucose‐Albumin Ratio on Patients With Cancer and Prescribed With Anthracycline Open
Aims This study aimed to investigate the clinical value of the glucose‐albumin ratio (GAR) in predicting the prognosis of cancer patients prescribed anthracycline‐based chemotherapy. Methods We included cancer patients who underwent anthra…
View article: Prognostic value of mechanical dyssynchrony in patients with heart failure: a systematic review
Prognostic value of mechanical dyssynchrony in patients with heart failure: a systematic review Open
Background Heart failure (HF) significantly impacts quality of life and healthcare systems worldwide. Assessing left ventricular mechanical dyssynchrony (LVMD) is crucial for understanding cardiac function and optimizing treatments like ca…
View article: Translational Research and Clinical Application of Traditional Chinese Medicine in Cardiovascular Diseases
Translational Research and Clinical Application of Traditional Chinese Medicine in Cardiovascular Diseases Open
Luobing theory is based on the principles of traditional Chinese medicine (TCM) and focuses on the regulation of blood circulation. The translation of Luobing theory into clinical practice has shown promising results in the treatment of ca…
View article: The traditional Chinese medicine Qiliqiangxin in heart failure with reduced ejection fraction: a randomized, double-blind, placebo-controlled trial
The traditional Chinese medicine Qiliqiangxin in heart failure with reduced ejection fraction: a randomized, double-blind, placebo-controlled trial Open
Previous findings have indicated the potential benefits of the Chinese traditional medicine Qiliqiangxin (QLQX) in heart failure. Here we performed a double-blind, randomized controlled trial to evaluate the efficacy and safety of QLQX in …
View article: Impacts of COPD Exacerbation History on Mortality and Severe Cardiovascular Events among Patients with COPD in China: A Retrospective Cohort Study
Impacts of COPD Exacerbation History on Mortality and Severe Cardiovascular Events among Patients with COPD in China: A Retrospective Cohort Study Open
Background Chronic Obstructive Pulmonary Disease (COPD) exacerbations are associated with increased mortality and cardiovascular events. However, there is limited evidence on the relationship between COPD exacerbations and mortality and ca…
View article: Correction: Trends in cardiovascular risk factor prevalence, treatment, and control among US adolescents aged 12 to 19 years, 2001 to March 2020
Correction: Trends in cardiovascular risk factor prevalence, treatment, and control among US adolescents aged 12 to 19 years, 2001 to March 2020 Open
View article: Trends in cardiovascular risk factor prevalence, treatment, and control among US adolescents aged 12 to 19 years, 2001 to March 2020
Trends in cardiovascular risk factor prevalence, treatment, and control among US adolescents aged 12 to 19 years, 2001 to March 2020 Open
View article: Glycated Hemoglobin Variability Is Associated With Adverse Outcomes in Patients With Heart Failure Irrespective of Diabetic Status
Glycated Hemoglobin Variability Is Associated With Adverse Outcomes in Patients With Heart Failure Irrespective of Diabetic Status Open
Background The effect of glycated hemoglobin (HbA 1c ) variability on adverse outcomes in patients with heart failure (HF) is unclear. We aim to investigate the predictive value of HbA 1c variability on the risks of all‐cause death and HF …
View article: Guideline-directed medical therapy in chemotherapy-induced cardiotoxicity and heart failure: current perspectives and practices
Guideline-directed medical therapy in chemotherapy-induced cardiotoxicity and heart failure: current perspectives and practices Open
Chemotherapy-induced cardiotoxicity and heart failure have become significant concerns in cancer treatment. Advancements in cancer therapies have increased survival rates, with consequent increase in the prevalence of chemotherapy-induced …
View article: Risk of hyperkalaemia in patients with type 2 diabetes mellitus prescribed with SGLT2 versus DPP-4 inhibitors
Risk of hyperkalaemia in patients with type 2 diabetes mellitus prescribed with SGLT2 versus DPP-4 inhibitors Open
Aims To investigate the risk of hyperkalaemia in new users of sodium–glucose cotransporter 2 (SGLT2) inhibitors vs. dipeptidyl peptidase-4 (DPP-4) inhibitors among patients with type 2 diabetes mellitus (T2DM). Methods and results Patients…
View article: Low lean mass with obesity in older adults with hypertension: prevalence and association with mortality rate
Low lean mass with obesity in older adults with hypertension: prevalence and association with mortality rate Open
View article: Associations of urinary di(2-ethylhexyl) phthalate metabolites with lipid profiles among US general adult population
Associations of urinary di(2-ethylhexyl) phthalate metabolites with lipid profiles among US general adult population Open
View article: Integrated Bioinformatic Analyses Reveal Immune Molecular Markers and Regulatory Networks for Cerebral Ischemia-Reperfusion
Integrated Bioinformatic Analyses Reveal Immune Molecular Markers and Regulatory Networks for Cerebral Ischemia-Reperfusion Open
Background: Cerebral ischemia-reperfusion injury (CIR) following a stroke results in secondary damage and is a leading cause of adult disability. The present study aimed to identify hub genes and networks in CIR to explore potential therap…
View article: Negative association between triglyceride glucose index and BMI-adjusted skeletal muscle mass index in hypertensive adults
Negative association between triglyceride glucose index and BMI-adjusted skeletal muscle mass index in hypertensive adults Open
Background The triglyceride glucose (TyG) index, an indicator of insulin resistance, is often associated with adverse outcomes in various cardiovascular diseases, while hypertension is associated with an increased risk of cardiovascular di…
View article: Prognostic value of ventricle epicardial fat volume by cardiovascular magnetic resonance in chronic heart failure
Prognostic value of ventricle epicardial fat volume by cardiovascular magnetic resonance in chronic heart failure Open
The purpose of this study is to explore the prognostic values of ventricle epicardial fat volume (EFV) calculated by cardiac magnetic resonance in patients with chronic heart failure (CHF). A total of 516 patients with CHF (left ventricula…
View article: Construction of a web‐based dynamic nomogram for predicting the prognosis in acute heart failure
Construction of a web‐based dynamic nomogram for predicting the prognosis in acute heart failure Open
Aims The early identification and appropriate management may provide clinically meaningful and substained benefits in patients with acute heart failure (AHF). This study aimed to develop an integrative nomogram with myocardial perfusion im…
View article: Associations of Serum Carotenoids With Risk of All‐Cause and Cardiovascular Mortality in Hypertensive Adults
Associations of Serum Carotenoids With Risk of All‐Cause and Cardiovascular Mortality in Hypertensive Adults Open
Background Systemic oxidative stress is involved in the development of hypertension, whereas carotenoids are a group of natural antioxidants. Our study aims to evaluate the relationships between the serum concentrations of major carotenoid…
View article: Efficacy and Safety of Qiliqiangxin in Patients with Heart Failure and Reduced Ejection Fraction:&nbsp;The QUEST Randomised Clinical Trial
Efficacy and Safety of Qiliqiangxin in Patients with Heart Failure and Reduced Ejection Fraction: The QUEST Randomised Clinical Trial Open
View article: CHA2DS2-VASc score for in-hospital recurrence risk stratification in patients with myocardial infarction
CHA2DS2-VASc score for in-hospital recurrence risk stratification in patients with myocardial infarction Open
Background Using the CHA 2 DS 2 -VASc score to recognize the risk of stroke in patients with atrial fibrillation has been well-established. However, few studies have assessed whether the CHA 2 DS 2 -VASc score has a similar predictive valu…
View article: Associations of Inflammation with Risk of Cardiovascular and All-Cause Mortality in Adults with Hypertension: An Inflammatory Prognostic Scoring System
Associations of Inflammation with Risk of Cardiovascular and All-Cause Mortality in Adults with Hypertension: An Inflammatory Prognostic Scoring System Open
Our results highlight that a higher IPS (system integrating the inflammatory markers) was associated with the increased risk of cardiovascular and all-cause mortality in patients with HTN, suggesting that IPS is a useful method for risk st…
View article: Inverse association of serum carotenoid levels with prevalence of hypertension in the general adult population
Inverse association of serum carotenoid levels with prevalence of hypertension in the general adult population Open
Carotenoid levels are inversely associated with blood pressure (BP). This study focused on the effects of individual and combined serum carotenoids on BP and hypertension, which have not been established to date. Data from National Health …