José Manuel Lopes
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View article: #2810 Characterization of membranous glomerulonephritis in adults presenting with nephrotic syndrome: a 13-year observational study
#2810 Characterization of membranous glomerulonephritis in adults presenting with nephrotic syndrome: a 13-year observational study Open
Background and Aims Membranous glomerulonephritis (MGN) is a major cause of nephrotic syndrome (NS) and nephrotic-range proteinuria. To better understand the population presenting with NS due to MGN, we analyzed our NS cohort over a 13-yea…
View article: #2820 Plasmapheresis as a life-saving intervention in amiodarone-induced thyroid storm
#2820 Plasmapheresis as a life-saving intervention in amiodarone-induced thyroid storm Open
Background and Aims Amiodarone-induced thyroid storm (AITS) is a rare but life-threatening endocrine emergency caused by excessive thyroid hormone levels. When standard medical therapies fail to achieve stabilization, plasmapheresis can se…
View article: ESTRATÉGIAS DE PREVENÇÃO DO CÂNCER DE PELE EM JOVENS PRATICANTES DE SURF: RELATO DE EXPERIÊNCIA
ESTRATÉGIAS DE PREVENÇÃO DO CÂNCER DE PELE EM JOVENS PRATICANTES DE SURF: RELATO DE EXPERIÊNCIA Open
View article: Buschke-Lowenstein Tumor: An Unusual Therapeutic Approach
Buschke-Lowenstein Tumor: An Unusual Therapeutic Approach Open
Giant condyloma acuminatum, known as Buschke-Lowenstein tumor, is a rare benign tumor. Several risk factors are described, including immunosuppression, diabetes, tobacco use, and multiple sexual partners, with about 90% of cases being asso…
View article: Cutaneous lesions and articular manifestations in multicentric reticulohistiocytosis: a diagnostic challenge
Cutaneous lesions and articular manifestations in multicentric reticulohistiocytosis: a diagnostic challenge Open
View article: Expert consensus and current landscape of NUT carcinoma: A comprehensive strategy from diagnosis to treatment
Expert consensus and current landscape of NUT carcinoma: A comprehensive strategy from diagnosis to treatment Open
Nuclear protein of the testis (NUT) carcinoma is a rare and highly aggressive malignancy characterized by the rearrangement of the NUT midline carcinoma family member 1 (NUTM1) gene. Nevertheless, standardized strategies for its diagnosis …
View article: Série temporal: internação e mortalidade por HIV entre indivíduos de 20 a 59 anos no Estado do Pará de 2008 a 2023
Série temporal: internação e mortalidade por HIV entre indivíduos de 20 a 59 anos no Estado do Pará de 2008 a 2023 Open
Objetivo: Investigar como o número de internações e óbitos por HIV nessa faixa etária evoluiu ao longo dos anos no estado do Pará. Métodos: O estudo foi realizado por meio de uma análise ecológica de dados fornecidos pelo DATASUS referente…
View article: Estudo do perfil epidemiológico dos exames histopatológico de neoplasia mamária na região metropolitana de Belém, Pará
Estudo do perfil epidemiológico dos exames histopatológico de neoplasia mamária na região metropolitana de Belém, Pará Open
Objetivo: Realizar um estudo epidemiológico baseado nos exames histopatológicos da Região Metropolitana de Belém (RMB), dos anos de 2019 a 2023. Métodos: Trata-se de estudo epidemiológico observacional descritivo do tipo transversal e méto…
View article: Formação de servidores públicos: uma experiência do LaBIM-RS
Formação de servidores públicos: uma experiência do LaBIM-RS Open
A indústria da construção civil no âmbito do setor público enfrenta constantemente diversos desafios, tais como recursos humanos e econômicos limitados, juntamente com a baixa flexibilidade e a alta burocratização dos processos. Com o prop…
View article: Biomarker Profiling of Upper Tract Urothelial Carcinoma Only and with Synchronous or Metachronous Bladder Cancer
Biomarker Profiling of Upper Tract Urothelial Carcinoma Only and with Synchronous or Metachronous Bladder Cancer Open
Background: Molecular profiling in upper tract urothelial carcinoma (UTUC) with synchronous or metachronous urothelial bladder cancer (UBC) is scarce. We intended to assess immunohistochemical (IHC) and genetic differences between UTUC-onl…
View article: Recapitulation of clinical features in a patient-derived xenograft mouse model of VEXAS Syndrome
Recapitulation of clinical features in a patient-derived xenograft mouse model of VEXAS Syndrome Open
Patient-derived xenografts (PDX) are valuable tools to model human disease and test new therapies. Here, we report, for the first time, a PDX model recapitulating the unique characteristics of a VEXAS patient (unique patient number UPN1).
View article: Tomografia torácica em Pneumonia por COVID-19: prevalência dos achados de imagem e fatores preditivos de óbito
Tomografia torácica em Pneumonia por COVID-19: prevalência dos achados de imagem e fatores preditivos de óbito Open
Objetivo: Avaliar a prevalência dos achados de imagem em tomografias torácicas em pacientes internados por pneumonia por COVID-19 e identificar alterações associadas a desfecho fatal. Métodos: Foram analisados 295 adultos internados por CO…
View article: Cellular iron governs the host response to malaria
Cellular iron governs the host response to malaria Open
Malaria and iron deficiency are major global health problems with extensive epidemiological overlap. Iron deficiency-induced anaemia can protect the host from malaria by limiting parasite growth. On the other hand, iron deficiency can sign…
View article: Generation of an Obese Diabetic Mouse Model upon Conditional Atrx Disruption
Generation of an Obese Diabetic Mouse Model upon Conditional Atrx Disruption Open
Atrx loss was recently ascertained as insufficient to drive pancreatic neuroendocrine tumour (PanNET) formation in mice islets. We have identified a preponderant role of Atrx in the endocrine dysfunction in a Rip-Cre;AtrxKO genetically eng…
View article: Improving non-small-cell lung cancer survival through molecular characterization: Perspective of a multidisciplinary expert panel
Improving non-small-cell lung cancer survival through molecular characterization: Perspective of a multidisciplinary expert panel Open
View article: Renovascular Hypertension: Unraveling a Case of Mixed Histiocytosis
Renovascular Hypertension: Unraveling a Case of Mixed Histiocytosis Open
Renovascular hypertension is a cause of secondary hypertension. Atherosclerotic renal artery stenosis and fibromuscular dysplasia are the main causes, but other rare entities can involve the renal arteries. Erdheim-Chester disease is a non…
View article: Data from Impact of <i>EGFR</i> Genetic Variants on Glioma Risk and Patient Outcome
Data from Impact of <i>EGFR</i> Genetic Variants on Glioma Risk and Patient Outcome Open
Background: The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. Three EGFR polymorphisms have been described as having a transcriptional regulatory …
View article: Supplementary Table 7 from Impact of <i>EGFR</i> Genetic Variants on Glioma Risk and Patient Outcome
Supplementary Table 7 from Impact of <i>EGFR</i> Genetic Variants on Glioma Risk and Patient Outcome Open
PDF file - 65.8KB
View article: Data from Impact of <i>EGFR</i> Genetic Variants on Glioma Risk and Patient Outcome
Data from Impact of <i>EGFR</i> Genetic Variants on Glioma Risk and Patient Outcome Open
Background: The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. Three EGFR polymorphisms have been described as having a transcriptional regulatory …
View article: Supplementary Table 7 from Impact of <i>EGFR</i> Genetic Variants on Glioma Risk and Patient Outcome
Supplementary Table 7 from Impact of <i>EGFR</i> Genetic Variants on Glioma Risk and Patient Outcome Open
PDF file - 65.8KB
View article: Supplementary Tables 1 - 6 from Impact of <i>EGFR</i> Genetic Variants on Glioma Risk and Patient Outcome
Supplementary Tables 1 - 6 from Impact of <i>EGFR</i> Genetic Variants on Glioma Risk and Patient Outcome Open
PDF file - 107KB
View article: Supplementary Tables 1 - 6 from Impact of <i>EGFR</i> Genetic Variants on Glioma Risk and Patient Outcome
Supplementary Tables 1 - 6 from Impact of <i>EGFR</i> Genetic Variants on Glioma Risk and Patient Outcome Open
PDF file - 107KB
View article: Cellular iron governs the host response to malaria
Cellular iron governs the host response to malaria Open
Malaria and iron deficiency are major global health problems with extensive epidemiological overlap. Iron deficiency-induced anaemia can protect the host from malaria by limiting parasite growth. On the other hand, iron deficiency can sign…
View article: Prognostic Value of Bladder Involvement in the Outcome of Upper Tract Urothelial Carcinoma
Prognostic Value of Bladder Involvement in the Outcome of Upper Tract Urothelial Carcinoma Open
Accurately predicting the clinical prognosis of upper tract urothelial carcinoma (UTUC) seems crucial. We evaluated the effect of the involvement of urothelial bladder carcinoma (UBC) as a potential prognostic factor for overall survival (…
View article: An update on genetically engineered mouse models of pancreatic neuroendocrine neoplasms
An update on genetically engineered mouse models of pancreatic neuroendocrine neoplasms Open
Pancreatic neuroendocrine neoplasms (PanNENs) are rare and clinically challenging entities. At the molecular level, PanNENs’ genetic profile is well characterized, but there is limited knowledge regarding the contribution of the newly iden…
View article: Clinicopathological features of head and neck cutaneous basal cell carcinoma observed at the Centro Hospitalar de Trás-os-Montes e Alto Douro ENT Department
Clinicopathological features of head and neck cutaneous basal cell carcinoma observed at the Centro Hospitalar de Trás-os-Montes e Alto Douro ENT Department Open
Background: Cutaneous basal cell carcinoma (cBCC) incidence has been increasing, but there are no available data on its epidemiological, clinical, and pathological patterns in Northeast Portugal. cBCC is mainly located in the head and neck…
View article: Characterisation of an Atrx Conditional Knockout Mouse Model: Atrx Loss Causes Endocrine Dysfunction Rather Than Pancreatic Neuroendocrine Tumour
Characterisation of an Atrx Conditional Knockout Mouse Model: Atrx Loss Causes Endocrine Dysfunction Rather Than Pancreatic Neuroendocrine Tumour Open
ATRX is a chromatin remodeller that maintains telomere homeostasis. Loss of ATRX is described in approximately 10% of pancreatic neuroendocrine tumours (PanNETs) and associated with poorer prognostic features. Here, we present a geneticall…
View article: Connexin Expression in Pituitary Adenomas and the Effects of Overexpression of Connexin 43 in Pituitary Tumor Cell Lines
Connexin Expression in Pituitary Adenomas and the Effects of Overexpression of Connexin 43 in Pituitary Tumor Cell Lines Open
Gap junction intercellular communication (GJIC) is considered a key mechanism in the regulation of tissue homeostasis. GJIC structures are organized in two transmembrane channels, with each channel formed by connexins (Cxs). GJIC and Cxs e…
View article: TERTp mutations and p53 expression in head and neck cutaneous basal cell carcinomas with different aggressive features
TERTp mutations and p53 expression in head and neck cutaneous basal cell carcinomas with different aggressive features Open
Cutaneous basal cell carcinoma (cBCC) is an economic burden to health services, due to its great morbidity and increasing incidence in old people. Infiltrative cBCCs and cBCCs with micronodular pattern are considered as more aggressive. Th…
View article: Combinatorial Therapies to Overcome BRAF/MEK Inhibitors Resistance in Melanoma Cells: An in vitro Study
Combinatorial Therapies to Overcome BRAF/MEK Inhibitors Resistance in Melanoma Cells: An in vitro Study Open
Our results suggest that the combination of MAPK pathway inhibitors with mTOR pathway inhibitors and DCA should be considered as therapeutic options to treat melanoma patients, as the combinations potentiated the effects of each drug alone…