Iosif Taleb
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View article: Hospital costs associated with mechanical left ventricular mechanical unloading devices during VA ECMO for adult cardiogenic shock
Hospital costs associated with mechanical left ventricular mechanical unloading devices during VA ECMO for adult cardiogenic shock Open
Importance No works to-date have described the financial burden and behaviors of left ventricular mechanical unloading (LVMU) for patients on veno-arterial extracorporeal membrane oxygenation (VA ECMO). Given the uptrending use of VA ECMO,…
View article: Informing Management of Patients Developing Cardiogenic Shock at a Spoke and Being Transferred to a Hub
Informing Management of Patients Developing Cardiogenic Shock at a Spoke and Being Transferred to a Hub Open
Background Multidisciplinary teams and regionalized care systems have been suggested to improve cardiogenic shock (CS) outcomes. We sought to identify clinical factors associated with successful outcomes for patients developing CS at an ou…
View article: A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease
A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease Open
BACKGROUND: Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate of ≈0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial. METHODS…
View article: Derivation and validation of a multicenter model to identify candidates for advanced HF therapies with high potential to achieve post-LVAD reverse cardiac remodeling
Derivation and validation of a multicenter model to identify candidates for advanced HF therapies with high potential to achieve post-LVAD reverse cardiac remodeling Open
Background A subset of advanced heart failure (HF) patients can experience significant improvement in their cardiac structure and function while on left ventricular assist device (LVAD) support, which is among the prerequisites for LVAD we…
View article: Impact of Diabetes and Glycemia on Cardiac Improvement and Adverse Events Following Mechanical Circulatory Support
Impact of Diabetes and Glycemia on Cardiac Improvement and Adverse Events Following Mechanical Circulatory Support Open
Background Type 2 diabetes is prevalent in cardiovascular disease and contributes to excess morbidity and mortality. We sought to investigate the effect of glycemia on functional cardiac improvement, morbidity, and mortality in durable lef…
View article: Bridge‐to‐transplant temporary mechanical circulatory support and risk of allosensitization
Bridge‐to‐transplant temporary mechanical circulatory support and risk of allosensitization Open
Introduction Since the 2018 change in the US adult heart allocation policy, more patients are bridged‐to‐transplant on temporary mechanical circulatory support (tMCS). Previous studies indicate that durable left ventricular assist devices …
View article: Integrating molecular and clinical variables to predict myocardial recovery
Integrating molecular and clinical variables to predict myocardial recovery Open
Mechanical unloading and circulatory support with left ventricular assist devices (LVADs) mediate significant myocardial improvement in a subset of advanced heart failure (HF) patients. The clinical and biological phenomena associated with…
View article: Artificial intelligence predictive analytics in heart failure: results of the pilot phase of a pragmatic randomized clinical trial
Artificial intelligence predictive analytics in heart failure: results of the pilot phase of a pragmatic randomized clinical trial Open
Objectives We conducted an implementation planning process during the pilot phase of a pragmatic trial, which tests an intervention guided by artificial intelligence (AI) analytics sourced from noninvasive monitoring data in heart failure …
View article: Machine Learning Multicenter Risk Model to Predict Right Ventricular Failure After Mechanical Circulatory Support
Machine Learning Multicenter Risk Model to Predict Right Ventricular Failure After Mechanical Circulatory Support Open
Importance The existing models predicting right ventricular failure (RVF) after durable left ventricular assist device (LVAD) support might be limited, partly due to lack of external validation, marginal predictive power, and absence of in…
View article: A latent cardiomyocyte regeneration potential in human heart disease
A latent cardiomyocyte regeneration potential in human heart disease Open
Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate around 0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial. Using retrospect…
View article: Distinct Transcriptomic and Proteomic Profile Specifies Patients Who Have Heart Failure With Potential of Myocardial Recovery on Mechanical Unloading and Circulatory Support
Distinct Transcriptomic and Proteomic Profile Specifies Patients Who Have Heart Failure With Potential of Myocardial Recovery on Mechanical Unloading and Circulatory Support Open
Background: Extensive evidence from single-center studies indicates that a subset of patients with chronic advanced heart failure (HF) undergoing left ventricular assist device (LVAD) support show significantly improved heart function and …
View article: Effect of Portable, In-Hospital Extracorporeal Membrane Oxygenation on Clinical Outcomes
Effect of Portable, In-Hospital Extracorporeal Membrane Oxygenation on Clinical Outcomes Open
The time between onset of cardiogenic shock and initiation of mechanical circulatory support is inversely related to patient survival as delays in transporting patients to the operating room (OR) for venoarterial extracorporeal membrane ox…
View article: LVAD as a Bridge to Remission from Advanced Heart Failure: Current Data and Opportunities for Improvement
LVAD as a Bridge to Remission from Advanced Heart Failure: Current Data and Opportunities for Improvement Open
Left ventricular assist devices (LVADs) are an established treatment modality for advanced heart failure (HF). It has been shown that through volume and pressure unloading they can lead to significant functional and structural cardiac impr…
View article: FGF21 (Fibroblast Growth Factor 21) Defines a Potential Cardiohepatic Signaling Circuit in End-Stage Heart Failure
FGF21 (Fibroblast Growth Factor 21) Defines a Potential Cardiohepatic Signaling Circuit in End-Stage Heart Failure Open
Background: Extrinsic control of cardiomyocyte metabolism is poorly understood in heart failure (HF). FGF21 (Fibroblast growth factor 21), a hormonal regulator of metabolism produced mainly in the liver and adipose tissue, is a prime candi…
View article: Circulating and Myocardial Cytokines Predict Cardiac Structural and Functional Improvement in Patients With Heart Failure Undergoing Mechanical Circulatory Support
Circulating and Myocardial Cytokines Predict Cardiac Structural and Functional Improvement in Patients With Heart Failure Undergoing Mechanical Circulatory Support Open
Background Recent prospective multicenter data from patients with advanced heart failure demonstrated that left ventricular assist device (LVAD) support combined with standard heart failure medications, induced significant cardiac structur…
View article: Baseline QRS Duration Associates with Cardiac Recovery in Patients with Continuous-Flow Left Ventricular Assist Device Implantation
Baseline QRS Duration Associates with Cardiac Recovery in Patients with Continuous-Flow Left Ventricular Assist Device Implantation Open
BACKGROUND In chronic heart failure (HF) patients supported with continuous-flow left ventricular assist device (CF-LVAD), we aimed to assess the clinical association of baseline QRS duration (QRSd) with post-LVAD cardiac recovery, and its…
View article: Framework to Classify Reverse Cardiac Remodeling With Mechanical Circulatory Support: The Utah-Inova Stages
Framework to Classify Reverse Cardiac Remodeling With Mechanical Circulatory Support: The Utah-Inova Stages Open
Background: Variable definitions and an incomplete understanding of the gradient of reverse cardiac remodeling following continuous flow left ventricular assist device (LVAD) implantation has limited the field of myocardial plasticity. We …
View article: Predicting mortality in cardiogenic shock secondary to <scp>ACS</scp> requiring <scp>short‐term</scp> mechanical circulatory support: The <scp>ACS‐MCS</scp> score
Predicting mortality in cardiogenic shock secondary to <span>ACS</span> requiring <span>short‐term</span> mechanical circulatory support: The <span>ACS‐MCS</span> score Open
Objective To identify predictors of 30‐day all‐cause mortality for patients with cardiogenic shock secondary to acute coronary syndrome (ACS‐CS) who require short‐term mechanical circulatory support (ST‐MCS). Background ACS‐CS mortality is…
View article: Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1
Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1 Open
The transcriptional regulatory machinery in mitochondrial bioenergetics is complex and is still not completely understood. We previously demonstrated that the histone methyltransferase Smyd1 regulates mitochondrial energetics. Here, we ide…
View article: The Role of Nonglycolytic Glucose Metabolism in Myocardial Recovery Upon Mechanical Unloading and Circulatory Support in Chronic Heart Failure
The Role of Nonglycolytic Glucose Metabolism in Myocardial Recovery Upon Mechanical Unloading and Circulatory Support in Chronic Heart Failure Open
Background: Significant improvements in myocardial structure and function have been reported in some patients with advanced heart failure (termed responders [R]) following left ventricular assist device (LVAD)–induced mechanical unloading.…