Iouri Chepelev
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View article: Sequencing and health data resource of children of African ancestry
Sequencing and health data resource of children of African ancestry Open
Purpose Individuals who self-report as Black or African American are historically underrepresented in genome-wide studies of disease risk, a disparity particularly evident in pediatric disease research. To address this gap, Cincinnati Chil…
View article: 703 Pervasive sharing of causal genetic risk factors contributes to clinical and molecular overlap between Sjögren’s Disease and SLE
703 Pervasive sharing of causal genetic risk factors contributes to clinical and molecular overlap between Sjögren’s Disease and SLE Open
Background/Purpose SLE (Systemic Lupus Erythematosus) and SjD (Sjögren's Disease) are similar diseases. Patients with these conditions share many overlapping features and some patients meet the classification criteria for both disease stat…
View article: 502 The epigenetics of the now known 330 lupus genetic risk loci in two ancestries are independently consonant with causal regulatory mechanisms involving epstein-barr virus (EBV)-encoded transcription co-factors expressed in EBV-infected, EBV latency III-expressing B cells (LCLs)
502 The epigenetics of the now known 330 lupus genetic risk loci in two ancestries are independently consonant with causal regulatory mechanisms involving epstein-barr virus (EBV)-encoded transcription co-factors expressed in EBV-infected, EBV latency III-expressing B cells (LCLs) Open
Background Multiple desperate results support the host immune response to Epstein-Barr virus (EBV) infection as a causal etiology for lupus with evidence supporting autoantibody generation through a molecular mimicry mechanism originating …
View article: 702 Comparative genome wide association studies (GWASs) of systemic lupus erythematosus (SLE) and multiple sclerosis (MS) from the million veteran program (MVP)
702 Comparative genome wide association studies (GWASs) of systemic lupus erythematosus (SLE) and multiple sclerosis (MS) from the million veteran program (MVP) Open
Background Strong evidence supports Epstein-Barr virus (EBV) being an original cause for most cases of both systemic lupus erythematosus (SLE) and multiple sclerosis (MS). The Million Veteran Program (MVP) data reduces artifacts from techn…
View article: 701 A million veteran program (MVP) genome-wide association study (GWAS) of systemic and cutaneous lupus erythematosus (SLE & CLE)
701 A million veteran program (MVP) genome-wide association study (GWAS) of systemic and cutaneous lupus erythematosus (SLE & CLE) Open
Background >36,000 Veterans have been diagnosed with systemic lupus erythematosus (SLE). With the SLE and cutaneous lupus (CLE) cases and unaffected controls in MVP, we performed a genome-wide association study (GWAS). Methods Cases with t…
View article: Modeling of horizontal pleiotropy identifies possible causal gene expression in systemic lupus erythematosus
Modeling of horizontal pleiotropy identifies possible causal gene expression in systemic lupus erythematosus Open
Background Systemic lupus erythematosus (SLE) is a chronic autoimmune condition with complex causes involving genetic and environmental factors. While genome-wide association studies (GWASs) have identified genetic loci associated with SLE…
View article: Pervasive Sharing of Causal Genetic Risk Factors Contributes to Clinical and Molecular Overlap between Sjögren’s Disease and Systemic Lupus Erythematosus
Pervasive Sharing of Causal Genetic Risk Factors Contributes to Clinical and Molecular Overlap between Sjögren’s Disease and Systemic Lupus Erythematosus Open
SjD (Sjögren’s Disease) and SLE (Systemic Lupus Erythematosus) are similar diseases. There is extensive overlap between the two in terms of both clinical features and pathobiologic mechanisms. Shared genetic risk is a potential explanation…
View article: LP-114 Lupus and multiple sclerosis may share an initiating pathogenesis: the anti- EBNA1 heuristic conjecture
LP-114 Lupus and multiple sclerosis may share an initiating pathogenesis: the anti- EBNA1 heuristic conjecture Open
Background In our studies of the relationship of the association of Epstein-Barr virus (EBV) infection with SLE we have also found an association of the anti-EBV Epstein-Barr Nuclear Antigen 1 (EBNA1) with SLE.1 Previously, we found that t…
View article: Correction: Stage-Dependent and Locus-Specific Role of Histone Demethylase Jumonji D3 (JMJD3) in the Embryonic Stages of Lung Development
Correction: Stage-Dependent and Locus-Specific Role of Histone Demethylase Jumonji D3 (JMJD3) in the Embryonic Stages of Lung Development Open
[This corrects the article DOI: 10.1371/journal.pgen.1004524.].
View article: 1401 A Genome Wide Association Scan of SLE genetic risk in a cohort of African-American persons
1401 A Genome Wide Association Scan of SLE genetic risk in a cohort of African-American persons Open
Systemic lupus erythematosus (SLE) is the prototypical multi-system autoimmune disease with diverse clinical features in persons with disease. SLE is also unified by characteristic autoimmunity directed against nucleic acid or nucleoprote…
View article: The US Department of Veterans Affairs Science and Health Initiative to Combat Infectious and Emerging Life-Threatening Diseases (VA SHIELD): A Biorepository Addressing National Health Threats
The US Department of Veterans Affairs Science and Health Initiative to Combat Infectious and Emerging Life-Threatening Diseases (VA SHIELD): A Biorepository Addressing National Health Threats Open
Background The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has demonstrated the need to share data and biospecimens broadly to optimize clinical outcomes for US …
View article: 101 Anti-EBNA1 molecular mimicry initiates cross-reacting autoantibodies in Systemic Lupus Erythematosus (SLE) & Multiple Sclerosis (MS)
101 Anti-EBNA1 molecular mimicry initiates cross-reacting autoantibodies in Systemic Lupus Erythematosus (SLE) & Multiple Sclerosis (MS) Open
Recent results1-3 support the hypothesis that SLE & MS autoantibodies arise from the anti- EBNA1 heteroimmune response. For example, SLE anti-SmB/B' autoantibodies appear to begin with a proline rich sequence from EBNA1 that differs from …
View article: 909 Haplotype-specific chromatin looping reveals genetic interactions of regulatory regions modulating gene expression at the SLE susceptibility locus <i>FAM167A-BLK</i>
909 Haplotype-specific chromatin looping reveals genetic interactions of regulatory regions modulating gene expression at the SLE susceptibility locus <i>FAM167A-BLK</i> Open
A major goal of genetics research is to elucidate mechanisms explaining how genetic variation contributes to phenotypic variation. The genetic variants identified in genome-wide association studies (GWASs) generally explain only a small p…
View article: Haplotype-specific chromatin looping reveals genetic interactions of regulatory regions modulating gene expression in 8p23.1
Haplotype-specific chromatin looping reveals genetic interactions of regulatory regions modulating gene expression in 8p23.1 Open
A major goal of genetics research is to elucidate mechanisms explaining how genetic variation contributes to phenotypic variation. The genetic variants identified in genome-wide association studies (GWASs) generally explain only a small pr…
View article: Epstein–Barr virus nuclear antigen 2 extensively rewires the human chromatin landscape at autoimmune risk loci
Epstein–Barr virus nuclear antigen 2 extensively rewires the human chromatin landscape at autoimmune risk loci Open
The interplay between environmental and genetic factors plays a key role in the development of many autoimmune diseases. In particular, the Epstein–Barr virus (EBV) is an established contributor to multiple sclerosis, lupus, and other diso…
View article: Validation of low‐coverage whole‐genome sequencing for mitochondrial DNA variants suggests mitochondrial DNA as a genetic cause of preterm birth
Validation of low‐coverage whole‐genome sequencing for mitochondrial DNA variants suggests mitochondrial DNA as a genetic cause of preterm birth Open
Preterm birth (PTB), or birth that occurs earlier than 37 weeks of gestational age, is a major contributor to infant mortality and neonatal hospitalization. Mutations in the mitochondrial genome (mtDNA) have been linked to various rare mit…
View article: Genome‐wide chromatin occupancy of BRDT and gene expression analysis suggest transcriptional partners and specific epigenetic landscapes that regulate gene expression during spermatogenesis
Genome‐wide chromatin occupancy of BRDT and gene expression analysis suggest transcriptional partners and specific epigenetic landscapes that regulate gene expression during spermatogenesis Open
BRDT, a member of the BET family of double bromodomain‐containing proteins, is essential for spermatogenesis in the mouse and has been postulated to be a key regulator of transcription in meiotic and post‐meiotic cells. To understand the f…
View article: Epstein-Barr virus nuclear antigen 2 (EBNA2) extensively rewires the human chromatin landscape at autoimmune risk loci
Epstein-Barr virus nuclear antigen 2 (EBNA2) extensively rewires the human chromatin landscape at autoimmune risk loci Open
The interplay between environmental and genetic factors plays a key role in the development of many autoimmune diseases. In particular, the Epstein-Barr virus (EBV) is an established contributor to multiple sclerosis, lupus, and other diso…
View article: Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis
Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis Open
Aberrant activation of the TAL1 is associated with up to 60% of T-ALL cases and is involved in CTCF-mediated genome organization within the TAL1 locus, suggesting that CTCF boundary plays a pathogenic role in T-ALL. Here, we show that −31-…
View article: Genomic features of BRDT binding sites in gene units suggest transcriptional partners and specific epigenetic landscapes to regulate transcriptional activity during spermatogenesis
Genomic features of BRDT binding sites in gene units suggest transcriptional partners and specific epigenetic landscapes to regulate transcriptional activity during spermatogenesis Open
BRDT, a member of the BET family of double bromodomain-containing proteins, is expressed uniquely in the male germ line, is essential for spermatogenesis in the mouse, and binds to acetylated transcription start sites of genes expressed in…
View article: Cyclin D1 integrates G9a-mediated histone methylation
Cyclin D1 integrates G9a-mediated histone methylation Open
Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, and pluripotency. The positionin…
View article: CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia
CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia Open
Key Points CRISPR-Cas9 library screening identifies CBS7/9 boundary that defines an aberrant HOXA chromatin domain and HOX gene transcription in AML. Attenuation of CBS7/9 boundary impairs the leukemic transcription program and attenuates …
View article: Association and comparisons of minor allele frequency of known SNP rs13277113 for lupus according to three identified Caucasian subgroups.
Association and comparisons of minor allele frequency of known SNP rs13277113 for lupus according to three identified Caucasian subgroups. Open
Association and comparisons of minor allele frequency of known SNP rs13277113 for lupus according to three identified Caucasian subgroups.