Iqra Aroob
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View article: GeneXpert MTB/RIF in diagnosis of tuberculous meningitis (TBM) in paediatric patients at a tertiary care children’s hospital in Pakistan over a period of 4 years
GeneXpert MTB/RIF in diagnosis of tuberculous meningitis (TBM) in paediatric patients at a tertiary care children’s hospital in Pakistan over a period of 4 years Open
The current study was planned to report the frequency of tuberculosis meningitis in the paediatric population of Pakistan using the GeneXpert Mycobacterium tuberculosis/Rifampicin (MTB/RIF) assay. Data of 569 cerebrospinal fluid samples co…
View article: Efficient extracellular production of α-amylase in Bacillus subtilis under the influence of xylose-inducible promoter
Efficient extracellular production of α-amylase in Bacillus subtilis under the influence of xylose-inducible promoter Open
This study focuses on the development of a xylose-inducible system to produce recombinant α-amylase from the bacterium Thermoactinomyces vulgaris 94-2A (amyTV) in the Bacillus expression system. To achieve this, a gene cassette was constru…
View article: Blood donation trend among healthcare providers at a tertiary care hospital in Pakistan: What can be the potential motivators and barriers
Blood donation trend among healthcare providers at a tertiary care hospital in Pakistan: What can be the potential motivators and barriers Open
BACKGROUND: The health system in Pakistan face increasing demand for blood and blood products due to a continuous increase in population, and hence patients. In this scenario, healthcare providers can serve as a readily available pool of v…
View article: High ceftazidime-avibactam resistance rate in carbapenem-resistant gram-negative organisms in Pakistan’s pediatric population
High ceftazidime-avibactam resistance rate in carbapenem-resistant gram-negative organisms in Pakistan’s pediatric population Open
Objective: This study investigates resistance to a newly available drug Ceftazidime–Avibactam (CAZ-AVI) in carbapenem-resistant gram-negative organisms (GNOs) in the Pakistan’s pediatric population. Methods: This was a prospective study ca…
View article: True incidence of acute transfusion reactions using active surveillance versus passive reporting among pediatric thalassemia patients at a tertiary care children’s hospital
True incidence of acute transfusion reactions using active surveillance versus passive reporting among pediatric thalassemia patients at a tertiary care children’s hospital Open
BACKGROUND: Blood transfusion therapy is the main therapy for thalassemia patients. Active reporting of acute reactions during blood transfusions can play a pivotal role in the prevention of under-reporting of these events. OBJECTIVE: The …
View article: Prevalence and Diagnosis of Rifampicin-Resistant Mycobacterium Tuberculosis using the GeneXpert MTB/RIF Assay at a Tertiary Care Children's Hospital
Prevalence and Diagnosis of Rifampicin-Resistant Mycobacterium Tuberculosis using the GeneXpert MTB/RIF Assay at a Tertiary Care Children's Hospital Open
Rifampicin is a primary anti-tuberculosis medication. Diagnosing multidrug-resistant tuberculosis (MDR-TB) remains a persistent challenge when examining both pulmonary and extra-pulmonary samples. Rapid detection of rifampicin resistance i…
View article: Ethylenediaminetetraacetic acid enhances structural stability and thermotolerance of recombinant cyclomaltodextrinase from Geobacillus thermopakistaniensis at higher temperatures.
Ethylenediaminetetraacetic acid enhances structural stability and thermotolerance of recombinant cyclomaltodextrinase from Geobacillus thermopakistaniensis at higher temperatures. Open
Ethylenediaminetetraacetic acid (EDTA), a chelating agent, has shown the ability to enhance the thermostability of cyclomaltodextrinase from Geobacillus thermopakistaniensis (CDaseGt). There was a 5-fold and 3-fold enhancement in the half-…
View article: Cyclodextrin-preferring glycoside hydrolases: properties and applications
Cyclodextrin-preferring glycoside hydrolases: properties and applications Open
Cyclodextrin-hydrolyzing enzymes are widespread in bacteria and archaea where they play their roles in carbohydrates metabolism. They were previously characterized as cyclodextrinases, neopullulanases and maltogenic amylases. In the Carboh…