Ira J. Blader
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View article: A call for the United States to continue investing in science
A call for the United States to continue investing in science Open
International audience
View article: PfFBXO1 is essential for inner membrane complex formation in Plasmodium falciparum during both asexual and transmission stages
PfFBXO1 is essential for inner membrane complex formation in Plasmodium falciparum during both asexual and transmission stages Open
Plasmodium species replicate via schizogony, which involves asynchronous nuclear divisions followed by semi-synchronous segmentation and cytokinesis. Successful segmentation requires a double-membranous structure known as the inner membran…
View article: Oxygen-dependent regulation of F-box proteins in Toxoplasma gondii is mediated by Skp1 glycosylation
Oxygen-dependent regulation of F-box proteins in Toxoplasma gondii is mediated by Skp1 glycosylation Open
A dynamic proteome is required for cellular adaption to changing environments including levels of O2, and the SKP1/CULLIN-1/F-box protein/RBX1 (SCF) family of E3 ubiquitin ligases contributes importantly to proteasome-mediated degradation.…
View article: The Toxoplasma oxygen-sensing protein, TgPhyA, is required for resistance to interferon gamma-mediated nutritional immunity in mice
The Toxoplasma oxygen-sensing protein, TgPhyA, is required for resistance to interferon gamma-mediated nutritional immunity in mice Open
As Toxoplasma gondii disseminates through its host, the parasite must sense and adapt to its environment and scavenge nutrients. Oxygen (O 2 ) is one such environmental factor and cytoplasmic prolyl 4-hydroxylases (PHDs) are evolutionarily…
View article: The Toxoplasma gondii F-Box Protein L2 Functions as a Repressor of Stage Specific Gene Expression
The Toxoplasma gondii F-Box Protein L2 Functions as a Repressor of Stage Specific Gene Expression Open
Toxoplasma gondii is a foodborne pathogen that can cause severe and life-threatening infections in fetuses and immunocompromised patients. Felids are its only definitive hosts, and a wide range of animals, including humans, serve as interm…
View article: <i>Toxoplasma gondii</i> harbors a hypoxia-responsive coproporphyrinogen dehydrogenase-like protein
<i>Toxoplasma gondii</i> harbors a hypoxia-responsive coproporphyrinogen dehydrogenase-like protein Open
Toxoplasma gondii is an apicomplexan parasite that is the cause of toxoplasmosis, a potentially lethal disease for immunocompromised individuals. During in vivo infection, the parasites encounter various growth environments, such as hypoxi…
View article: <i>Toxoplasma gondii</i>F-Box Protein L2 Silences Feline-Restricted Genes Necessary for Sexual Commitment
<i>Toxoplasma gondii</i>F-Box Protein L2 Silences Feline-Restricted Genes Necessary for Sexual Commitment Open
Toxoplasma gondii is a foodborne pathogen that can cause severe and life-threatening infections in fetuses and immunocompromised patients. Felids are its only definitive hosts, and a wide range of animals, including humans, serve as interm…
View article: <i>Toxoplasma gondii</i>harbors a hypoxia-responsive coproporphyrinogen dehydrogenase-like protein
<i>Toxoplasma gondii</i>harbors a hypoxia-responsive coproporphyrinogen dehydrogenase-like protein Open
Toxoplasma gondii is an apicomplexan parasite that is the cause of toxoplasmosis, a potentially lethal disease for immunocompromised individuals. During in vivo infection, the parasites encounter various growth environments, such as hypoxi…
View article: Identification of <i>Toxoplasma</i> calcium-dependent protein kinase 3 as a stress-activated elongation factor 2 kinase
Identification of <i>Toxoplasma</i> calcium-dependent protein kinase 3 as a stress-activated elongation factor 2 kinase Open
Toxoplasma gondii is an obligate intracellular parasite whose tachyzoite form causes disease via a lytic growth cycle. Its metabolic and cellular pathways are primarily designed to ensure parasite survival within a host cell. But during it…
View article: The<i>Toxoplasma</i>Oxygen Sensing Protein, TgPhyA, Is Required for Resistance to Interferon-gamma Mediated Nutritional Immunity
The<i>Toxoplasma</i>Oxygen Sensing Protein, TgPhyA, Is Required for Resistance to Interferon-gamma Mediated Nutritional Immunity Open
As Toxoplasma gondii disseminates through its host, the parasite must sense and adapt to its environment and scavenge nutrients. Oxygen (O 2 ) is one such environmental factor and cytoplasmic prolyl 4-hydroxylases (PHDs) are evolutionarily…
View article: Identification of<i>Toxoplasma</i>Calcium Dependent Protein Kinase 3 as a Stress-Activated Elongation Factor 2 Kinase
Identification of<i>Toxoplasma</i>Calcium Dependent Protein Kinase 3 as a Stress-Activated Elongation Factor 2 Kinase Open
Toxoplasma gondii is an obligate intracellular parasite whose tachyzoite form causes disease via a lytic growth cycle. Its metabolic and cellular pathways are primarily designed to ensure parasite survival within a host cell. But during it…
View article: Complement‐dependent loss of inhibitory synapses on pyramidal neurons following <i>Toxoplasma gondii</i> infection
Complement‐dependent loss of inhibitory synapses on pyramidal neurons following <i>Toxoplasma gondii</i> infection Open
The apicomplexan parasite Toxoplasma gondii has developed mechanisms to establish a central nervous system infection in virtually all warm‐blooded animals. Acute T. gondii infection can cause neuroinflammation, encephalitis, and seizures. …
View article: Complement-dependent loss of inhibitory synapses on pyramidal neurons following<i>Toxoplasma gondii</i>infection
Complement-dependent loss of inhibitory synapses on pyramidal neurons following<i>Toxoplasma gondii</i>infection Open
The apicomplexan parasite Toxoplasma gondii has developed mechanisms to establish a central nervous system infection in virtually all warm-blooded animals. Acute T. gondii infection can cause neuroinflammation, encephalitis, and seizures. …
View article: The<i>Toxoplasma</i>Polymorphic Effector GRA15 Mediates Seizure Induction by Modulating Interleukin-1 Signaling in the Brain
The<i>Toxoplasma</i>Polymorphic Effector GRA15 Mediates Seizure Induction by Modulating Interleukin-1 Signaling in the Brain Open
Inflammation in the brain caused by infections lead to seizures and other neurological symptoms. But the microbial products that induce seizures as well as the host pathways downstream of these factors are largely unknown.
View article: Recommendations for future university pandemic responses: What the first COVID-19 shutdown taught us
Recommendations for future university pandemic responses: What the first COVID-19 shutdown taught us Open
The SARS-CoV-2 epidemic challenged universities and other academic institutions to rapidly adapt to urgent and life-threatening situations. It forced most institutions to shut down nearly every aspect of their research and educational ente…