Iram Murtaza
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View article: Correction: Targeting NLRP3 and AIM2 signaling pathways by Viscosol alleviates metabolic dysregulations induced inflammatory responses in diabetic neuro- and nephropathy: An in silico and in vivo study
Correction: Targeting NLRP3 and AIM2 signaling pathways by Viscosol alleviates metabolic dysregulations induced inflammatory responses in diabetic neuro- and nephropathy: An in silico and in vivo study Open
[This corrects the article DOI: 10.1371/journal.pone.0313816.].
View article: An integrated bioinformatics approach for identification of key modulators and biomarkers involved in atrial fibrillation
An integrated bioinformatics approach for identification of key modulators and biomarkers involved in atrial fibrillation Open
Introduction: Atrial fibrillation (AFib) is a sustained form of cardiac arrythmia that occurs due to sympathetic overdrive, neurohumoral and electrophysiological changes. Sympatho-renal modulatory approach via miRNA-based therapeutics is l…
View article: Targeting NLRP3 and AIM2 signaling pathways by Viscosol alleviates metabolic dysregulations induced inflammatory responses in diabetic neuro- and nephropathy: An in silico and in vivo study
Targeting NLRP3 and AIM2 signaling pathways by Viscosol alleviates metabolic dysregulations induced inflammatory responses in diabetic neuro- and nephropathy: An in silico and in vivo study Open
Type 2 Diabetes (T2D) is a chronic metabolic disorder, considered the fastest growing pandemic of the 21 st century. Meta-inflammation is a pivotal characteristic of T2D. Hyperactivated PTP1B, NLRP3, and AIM2 inflammasomes are considered t…
View article: Burn Injuries in Epileptic Patients: Prevalence, Causes, and Outcomes - A Cross Sectional Study at Pak Italian Burn Center Nishter Hospital Multan
Burn Injuries in Epileptic Patients: Prevalence, Causes, and Outcomes - A Cross Sectional Study at Pak Italian Burn Center Nishter Hospital Multan Open
Objective: To evaluate the patterns of burn injuries, identifying the prevalence, causative factors and outcomes of burn injuries among patients of epilepsy admitted to the Pak-Italian Burn Center, Nishtar Hospital Multan. Methodology: A d…
View article: Prevalence of Type 2 Diabetes Mellitus Among Pulmonary Tuberculosis Patients in Pakistan
Prevalence of Type 2 Diabetes Mellitus Among Pulmonary Tuberculosis Patients in Pakistan Open
Background: Individuals with diabetes are vulnerable to a weakened immune response, increasing the risk of pulmonary tuberculosis (TB), particularly in low- to middle-income countries like Pakistan with prevalent poverty and unsanitary con…
View article: In Silico, In Vitro, and In Vivo Evaluation of Caffeine-Coated Nanoparticles as a Promising Therapeutic Avenue for AML through NF-Kappa B and TRAIL Pathways Modulation
In Silico, In Vitro, and In Vivo Evaluation of Caffeine-Coated Nanoparticles as a Promising Therapeutic Avenue for AML through NF-Kappa B and TRAIL Pathways Modulation Open
Background: Advancements in nanoscience have led to a profound paradigm shift in the therapeutic applications of medicinally important natural drugs. The goal of this research is to develop a nano-natural product for efficient cancer treat…
View article: Mutation and Expression Analysis of Gastrointestinal Stromal Tumor Associated Genes Spectrum in a Pakistani Male through Comprehensive Next-generation Sequencing
Mutation and Expression Analysis of Gastrointestinal Stromal Tumor Associated Genes Spectrum in a Pakistani Male through Comprehensive Next-generation Sequencing Open
Purpose This case study covers a Pakistani man with GIST at the gastroesophageal junction, which is rare and confirmed by CT scan and immunophenotyping (Desmin+, CD117+, SMA+) and we aimed to probe the mutational landscape through NGS tech…
View article: <i>CYP2C19*17</i> association with higher plasma 4-hydroxy tamoxifen in Pakistani (estrogen-positive) breast cancer patients
<i>CYP2C19*17</i> association with higher plasma 4-hydroxy tamoxifen in Pakistani (estrogen-positive) breast cancer patients Open
Breast cancer (BC) continues to be the most common cancer in the women worldwide. Since estrogen receptor (ER)-positive BC accounts for the majority of newly diagnosed cases, endocrine therapy is advised to utilize either tamoxifen (Tam) o…
View article: Investigating the Role of Bisphenol A in the Prevalence of Breast Cancer in Pakistani Population
Investigating the Role of Bisphenol A in the Prevalence of Breast Cancer in Pakistani Population Open
Breast cancer is an abnormal division of breast cells. Bisphenol A (BPA), an environmental toxicant is identified as an emerging risk factor for breast cancer development. However, to the best of our knowledge no previous study has investi…
View article: CCDC 2223315: Experimental Crystal Structure Determination
CCDC 2223315: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Profiling of Targeted miRNAs (8-nt) for the Genes Involved in Type 2 Diabetes Mellitus and Cardiac Hypertrophy
Profiling of Targeted miRNAs (8-nt) for the Genes Involved in Type 2 Diabetes Mellitus and Cardiac Hypertrophy Open
Type 2 Diabetes Mellitus (T2DM) and cardiac hypertrophy (CH) are among the top ten leading cause of deaths, worldwide. T2DM and cardiac hypertrophy are the chronic diseases, have close association and direct life-threatening complications …
View article: Neuroprotective Effect of Otostegia limbata Against PTZ-Induced Mice Model of Epilepsy by Attenuated Expression of p-NFκB and TNF-α
Neuroprotective Effect of Otostegia limbata Against PTZ-Induced Mice Model of Epilepsy by Attenuated Expression of p-NFκB and TNF-α Open
Epilepsy is a chronic neurological disorder characterized by recurrent unprovoked seizures. Currently available antiepileptic drugs have severe side effects and do not offer complete cure. Herbal remedies have been used for centuries to tr…
View article: C‐Reactive Protein and High‐Sensitive Cardiac Troponins Correlate with Oxidative Stress in Valvular Heart Disease Patients
C‐Reactive Protein and High‐Sensitive Cardiac Troponins Correlate with Oxidative Stress in Valvular Heart Disease Patients Open
Background . Valvular heart disease (VHD) is a major contributor to loss of physical function and longevity. Oxidative stress is one of the key causative factors involved in heart disease including VHD. Here, we aimed to illuminate the rol…
View article: CCDC 2040445: Experimental Crystal Structure Determination
CCDC 2040445: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: N-Acetyl Cysteine, Selenium, and Ascorbic Acid Rescue Diabetic Cardiac Hypertrophy via Mitochondrial-Associated Redox Regulators
N-Acetyl Cysteine, Selenium, and Ascorbic Acid Rescue Diabetic Cardiac Hypertrophy via Mitochondrial-Associated Redox Regulators Open
Metabolic disorders often lead to cardiac complications. Metabolic deregulations during diabetic conditions are linked to mitochondrial dysfunctions, which are the key contributing factors in cardiac hypertrophy. However, the underlying me…
View article: Genetic Association of FTO rs9939609 Polymorphism with Hypertension in Pakistani Population
Genetic Association of FTO rs9939609 Polymorphism with Hypertension in Pakistani Population Open
Background: Hypertension is a medical condition that often occurs parallel to diabetes and obesity. Previously, the role of fat mass and obesity associated (FTO) gene rs9939609 polymorphism (c.46-23525T>A) with obesity has been reported wh…
View article: MicroRNAs in molecular technology to address global diseases bench to bedside research
MicroRNAs in molecular technology to address global diseases bench to bedside research Open
MicroRNAs a category of noncoding RNA dysregulations are involved in numerous pathological conditions including cancer, diabetes, heart diseases, immunological disorders, neurological diseases and many metabolic diseases. Advancement in th…
View article: Combined Efficacy of Cinnamomum Zeylanicum And Doxorubicin Against Leukemia Through Regulation of TRAIL And NF-Kappa B Pathways In Rat Model
Combined Efficacy of Cinnamomum Zeylanicum And Doxorubicin Against Leukemia Through Regulation of TRAIL And NF-Kappa B Pathways In Rat Model Open
Background: Recent discoveries in cancer therapeutics have proven combination therapies more effective than individual drugs. This study describes the efficacy of Cinnamomum zeylanicum and doxorubicin combination against benzene-induced le…
View article: Persistent Inadequacies in Infant and Young Child Feeding Practices and Their Determinants
Persistent Inadequacies in Infant and Young Child Feeding Practices and Their Determinants Open
Background: Malnutrition is a major public health problem and is directly associated with poor infant and young child feeding (IYCF) practices. The study aimed to identify the inadequacies in the feeding practices for children aged 0-23 mo…
View article: Melatonin Act as an Antidepressant via Attenuation of Neuroinflammation by Targeting Sirt1/Nrf2/HO-1 Signaling
Melatonin Act as an Antidepressant via Attenuation of Neuroinflammation by Targeting Sirt1/Nrf2/HO-1 Signaling Open
Physical or psychological stress can cause an immunologic imbalance that disturbs the central nervous system followed by neuroinflammation. The association between inflammation and depression has been widely studied in recent years, though…
View article: Analysis of NT-proBNP and uric acid due to left ventricle hypertrophy in the patients of aortic valve disease
Analysis of NT-proBNP and uric acid due to left ventricle hypertrophy in the patients of aortic valve disease Open
Objective: To evaluate the concentration of N terminal proBNP (NT-proBNP) and partially the serum uric acid in the severe condition of aortic valve dysfunction for assessment of left ventricle hypertrophy.
Methods: The study was conducted…
View article: In vitro bioactivities and subacute toxicity study of <i>O. basilicum</i> , <i>T. vulgaris</i> and <i>R. officinalis</i>
In vitro bioactivities and subacute toxicity study of <i>O. basilicum</i> , <i>T. vulgaris</i> and <i>R. officinalis</i> Open
Background Ocimum basilicum , Thymus vulgaris , and Rosmarinus officinalis have been used for the treatment of different ailments for a historically long time but there have been no safety studies of these plants. Phytoconstituents of thes…
View article: Expression of Cucumber mosaic virus suppressor 2b alters FWA methylation and its siRNA accumulation in <i>Arabidopsis thaliana</i>
Expression of Cucumber mosaic virus suppressor 2b alters FWA methylation and its siRNA accumulation in <i>Arabidopsis thaliana</i> Open
The Cucumber mosaic virus (CMV) suppressor 2b co-localizes with AGO4 in cytoplasmic and nuclear fractions of Arabidopsis thaliana. Biochemical fractionation of A. thaliana cellular extracts revealed that 2b and AGO4 coexist in multiple siz…
View article: Effect of Hexane and Ethanol Extracts of Ten Basil Genotypes on the Growth of Selected Bacterial Strains
Effect of Hexane and Ethanol Extracts of Ten Basil Genotypes on the Growth of Selected Bacterial Strains Open
Bacterial infections are a nuisance to mankind from prehistoric times and still alive particularly in third world countries, where medicinal plants are extensively used as a treatment to pathogens since the known human history. In the curr…
View article: Extracellular vesicles in ovarian cancer: applications to tumor biology, immunotherapy and biomarker discovery
Extracellular vesicles in ovarian cancer: applications to tumor biology, immunotherapy and biomarker discovery Open
In recent years there has been tremendous interest in both the basic biology and applications of extracellular vesicles (EVs) in translational cancer research. This includes a better understanding of their biogenesis and mechanisms of sele…