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View article: Nutritional Aspects of Eggs for a Healthy and Sustainable Consumption: A Narrative Review
Nutritional Aspects of Eggs for a Healthy and Sustainable Consumption: A Narrative Review Open
Despite being recognized as a low‐cost food, rich in proteins and other nutrients, for years eggs have been the subject of controversy regarding a possible negative impact on human health linked to their frequent consumption and their chol…
View article: NNMT drives innate sensitivity to NAMPT inhibition in YAP-dependent stem-like/ mesenchymal prostate cancer
NNMT drives innate sensitivity to NAMPT inhibition in YAP-dependent stem-like/ mesenchymal prostate cancer Open
Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the NAD+ salvage pathway and a promising therapeutic target in cancer. Resistance to NAMPT inhibitors, such as FK866, remains a key limitation to their clinical …
View article: Prognostic Frailty-Based Determinants of Long-Term Mortality in Older Patients with Newly Diagnosed Multiple Myeloma
Prognostic Frailty-Based Determinants of Long-Term Mortality in Older Patients with Newly Diagnosed Multiple Myeloma Open
Background/Objectives: Multiple myeloma (MM) is a plasma cell neoplasm predominantly diagnosed in older adults. However, the significance of defining patient frailty, as well as identifying the most suitable and reliable tools for its asse…
View article: Effect of egg consumption on health outcomes: An updated umbrella review of systematic reviews and meta-analysis of observational and intervention studies
Effect of egg consumption on health outcomes: An updated umbrella review of systematic reviews and meta-analysis of observational and intervention studies Open
Due to the critically low strength of studies, insufficient evidence is available to discourage egg consumption, suggesting eggs can be part of a healthy diet.
View article: Aging-Related Mechanisms Underlying Carcinogenesis: Therapeutic Opportunities
Aging-Related Mechanisms Underlying Carcinogenesis: Therapeutic Opportunities Open
Aging is a gradual loss of tissue homeostasis that leads to impaired physiological organ functions and constitutes a major risk factor for cancer initiation and progression. Despite advances in anti-tumor therapies, cancer remains the seco…
View article: Prognostic frailty-based determinants of long-term mortality in older patients with newly diagnosed multiple myeloma
Prognostic frailty-based determinants of long-term mortality in older patients with newly diagnosed multiple myeloma Open
Introduction Multiple myeloma (MM) is a plasma cell neoplasm predominantly diagnosed in older adults. However, the significance of defining patient frailty, as well as identifying the most suitable and reliable tools for its assessment, re…
View article: Short‐term starvation activates AMPK and restores mitochondrial inorganic polyphosphate, but fails to reverse associated neuronal senescence
Short‐term starvation activates AMPK and restores mitochondrial inorganic polyphosphate, but fails to reverse associated neuronal senescence Open
Neuronal senescence is a major risk factor for the development of many neurodegenerative disorders. The mechanisms that drive neurons to senescence remain largely elusive; however, dysregulated mitochondrial physiology seems to play a pivo…
View article: New Analogues of the Nicotinamide Phosphoribosyltransferase InhibitorFK866 as Potential Anti-Pancreatic Cancer Agents
New Analogues of the Nicotinamide Phosphoribosyltransferase InhibitorFK866 as Potential Anti-Pancreatic Cancer Agents Open
Background: During the past two decades, many nicotinamide phosphoribosyltransferase (NAMPT) inhibitors were prepared and tested because this enzyme is overexpressed in pancreatic cancer. Although FK866 is a well-known, strong NAMPT inhibi…
View article: Inhibitors of NAD+ Production in Cancer Treatment: State of the Art and Perspectives
Inhibitors of NAD+ Production in Cancer Treatment: State of the Art and Perspectives Open
The addiction of tumors to elevated nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of cancer metabolism. Obstructing NAD+ biosynthesis in tumors is a new and promising antineoplastic strategy. Inhibitors developed against ni…
View article: Author Correction: Cyclic fasting bolsters cholesterol biosynthesis inhibitors’ anticancer activity
Author Correction: Cyclic fasting bolsters cholesterol biosynthesis inhibitors’ anticancer activity Open
View article: Cyclic fasting bolsters cholesterol biosynthesis inhibitors’ anticancer activity
Cyclic fasting bolsters cholesterol biosynthesis inhibitors’ anticancer activity Open
View article: Iminosugar-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Potential Anti-Pancreatic Cancer Agents
Iminosugar-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Potential Anti-Pancreatic Cancer Agents Open
The nicotinamide phosphoribosyltransferase (NAMPT) is considered a very promising therapeutic target because it is overexpressed in pancreatic cancer. Although many inhibitors have been prepared and tested, clinical trials have shown that …
View article: Mitochondrial rewiring drives metabolic adaptation to NAD(H) shortage in triple negative breast cancer cells
Mitochondrial rewiring drives metabolic adaptation to NAD(H) shortage in triple negative breast cancer cells Open
View article: Supplementary Figures legend from APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells
Supplementary Figures legend from APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells Open
Supplementary Figures legend
View article: Data from APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells
Data from APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells Open
Purpose: The nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, APO866, has been previously shown to have antileukemic activity in preclinical models, but its cytotoxicity in primary leukemia cells is frequently limited. The …
View article: Supplemental Materials and Methods from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair
Supplemental Materials and Methods from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair Open
Supplemental Materials and Methods shows experimental methods, including the immunohistochemical (IHC) analysis of NAPRT expression in primary ovarian cancer and the cloning of NAPRT-EGFP and of wild type NAPRT.
View article: Supplementary Figures legend from APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells
Supplementary Figures legend from APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells Open
Supplementary Figures legend
View article: Supplemental Materials and Methods from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair
Supplemental Materials and Methods from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair Open
Supplemental Materials and Methods shows experimental methods, including the immunohistochemical (IHC) analysis of NAPRT expression in primary ovarian cancer and the cloning of NAPRT-EGFP and of wild type NAPRT.
View article: Figure S2 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair
Figure S2 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair Open
Figure S2 shows that NAPRT silencing does not induce compensatory NAMPT upregulation in cancer cells.
View article: Data from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair
Data from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair Open
In the last decade, substantial efforts have been made to identify NAD+ biosynthesis inhibitors, specifically against nicotinamide phosphoribosyltransferase (NAMPT), as preclinical studies indicate their potential efficacy as ca…
View article: Supplemental Figures 1-8 from APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells
Supplemental Figures 1-8 from APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells Open
Supplemental Figures 1-8. Figure 1S: A) Nampt locus (human chromosome 7q22.3) copy number heatmap for lines included in the Cancer Cell Line Encyclopedia. B) mRNA Nampt expression plotted vs. DNA copy number (log2 ratio). Figure 2S: effect…
View article: Figure S4 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair
Figure S4 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair Open
Figure S4 shows that NAPRT is a cytosolic and nuclear protein that regulates cancer cell metabolism and susceptibility to FK866.
View article: Figure S1 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair
Figure S1 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair Open
Figure S1 shows the frequency of QPRT, NMRK1, and NMRK2 gene amplification in human tumors and NAPRT expression in common human cancers.
View article: Figure S2 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair
Figure S2 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair Open
Figure S2 shows that NAPRT silencing does not induce compensatory NAMPT upregulation in cancer cells.
View article: Figure S1 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair
Figure S1 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair Open
Figure S1 shows the frequency of QPRT, NMRK1, and NMRK2 gene amplification in human tumors and NAPRT expression in common human cancers.
View article: Figure S6 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair
Figure S6 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair Open
Figure S6 shows that NAPRT overexpression confers resistance to FK866 to MIA PaCa2 cells, but resistance is reverted by 2-HNA.
View article: Figure S7 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair
Figure S7 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair Open
Figure S7 shows that 2-hydroxynicotinate sodium salt (2-HNANa) effectively sensitizes OVCAR-5 cells to FK866.
View article: Figure S7 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair
Figure S7 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair Open
Figure S7 shows that 2-hydroxynicotinate sodium salt (2-HNANa) effectively sensitizes OVCAR-5 cells to FK866.
View article: Figure S5 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair
Figure S5 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair Open
Figure S5 shows that 2-HNA inhibits NAPRT enzymatic activity and increases glycolysis in OVCAR-5 cells.
View article: Figure S6 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair
Figure S6 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair Open
Figure S6 shows that NAPRT overexpression confers resistance to FK866 to MIA PaCa2 cells, but resistance is reverted by 2-HNA.