Irene Mattioli
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View article: ROS‐induced modifications of fibrin clots connect immune responses to atherothrombosis in systemic lupus erythematosus
ROS‐induced modifications of fibrin clots connect immune responses to atherothrombosis in systemic lupus erythematosus Open
Objective Cardiovascular events are major determinants of morbidity and mortality in systemic lupus erythematosus (SLE), particularly in patients with renal involvement. While oxidative stress has been implicated in driving vascular and re…
View article: Incidence and prevalence of systemic lupus erythematosus across Italian referral centers and its clinical burden in terms of disease severity, treatment and hospitalization: The ESCULAPIO study
Incidence and prevalence of systemic lupus erythematosus across Italian referral centers and its clinical burden in terms of disease severity, treatment and hospitalization: The ESCULAPIO study Open
This study provides insights into epidemiological, clinical, and therapeutic features of SLE across referral centers highlighting significant regional disparities and emphasizing the need to increasingly align with EULAR recommendations ev…
View article: POS0569 Early Access Program (EAP) of Avacopan for the Treatment of ANCA-Associated Vasculitis (AAV): The Italian Multicenter Prospective Real-World Experience Beyond 52 Weeks
POS0569 Early Access Program (EAP) of Avacopan for the Treatment of ANCA-Associated Vasculitis (AAV): The Italian Multicenter Prospective Real-World Experience Beyond 52 Weeks Open
View article: OP0170 LONG-TERM TREATMENT WITH LOW-DOSE MEPOLIZUMAB FOR EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS: FOLLOW-UP RESULTS FROM THE EUROPEAN EGPA STUDY GROUP
OP0170 LONG-TERM TREATMENT WITH LOW-DOSE MEPOLIZUMAB FOR EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS: FOLLOW-UP RESULTS FROM THE EUROPEAN EGPA STUDY GROUP Open
View article: Mepolizumab versus benralizumab for eosinophilic granulomatosis with polyangiitis (EGPA): A European real-life retrospective comparative study
Mepolizumab versus benralizumab for eosinophilic granulomatosis with polyangiitis (EGPA): A European real-life retrospective comparative study Open
View article: Mepolizumab vs Benralizumab for Eosinophilic Granulomatosis with Polyangiitis (EGPA): a European comparative study Short running title: Mepolizumab versus Benralizumab for EGPA
Mepolizumab vs Benralizumab for Eosinophilic Granulomatosis with Polyangiitis (EGPA): a European comparative study Short running title: Mepolizumab versus Benralizumab for EGPA Open
View article: Efficacy and safety of infliximab or adalimumab in severe mucocutaneous Behçet's syndrome refractory to traditional immunosuppressants: a 6-month, multicentre, randomised controlled, prospective, parallel group, single-blind trial
Efficacy and safety of infliximab or adalimumab in severe mucocutaneous Behçet's syndrome refractory to traditional immunosuppressants: a 6-month, multicentre, randomised controlled, prospective, parallel group, single-blind trial Open
The overall results of this study confirm the effectiveness of both IFX and ADA in achieving remission in patients with BS affected by mucocutaneous involvement.
View article: Multimodal nonlinear correlates of behavioural symptoms in frontotemporal dementia
Multimodal nonlinear correlates of behavioural symptoms in frontotemporal dementia Open
Studies exploring the brain correlates of behavioral symptoms in the frontotemporal dementia spectrum (FTD) have mainly searched for linear correlations with single modality neuroimaging data, either structural magnetic resonance imaging (…
View article: Factor XI Inhibitors: perspectives in primary and secondary prevention of ischemic stroke
Factor XI Inhibitors: perspectives in primary and secondary prevention of ischemic stroke Open
View article: Epidemiology of SLE in Italy: an observational study using a primary care database
Epidemiology of SLE in Italy: an observational study using a primary care database Open
Objectives To estimate the incidence and prevalence of SLE in Italy, and to describe the demographic and clinical characteristics of patients with newly diagnosed SLE. Methods A retrospective cohort study was conducted using The Health Imp…
View article: Ophthalmic vascular manifestations in eosinophil-associated diseases: a comprehensive analysis of 57 patients from the CEREO and EESG networks and a literature review
Ophthalmic vascular manifestations in eosinophil-associated diseases: a comprehensive analysis of 57 patients from the CEREO and EESG networks and a literature review Open
Introduction Eosinophils have widespread procoagulant effects. In daily practice, eosinophil-related cardiovascular toxicity consists of endomyocardial damage, eosinophilic vasculitis and arterial or venous thrombosis. Here we aim to repor…
View article: Management of pregnancy in autoimmune rheumatic diseases: maternal disease course, gestational and neonatal outcomes and use of medications in the prospectiveItalian P-RHEUM.it study
Management of pregnancy in autoimmune rheumatic diseases: maternal disease course, gestational and neonatal outcomes and use of medications in the prospectiveItalian P-RHEUM.it study Open
Objectives To investigate pregnancy outcomes in women with autoimmune rheumatic diseases (ARD) in the Italian prospective cohort study P-RHEUM.it. Methods Pregnant women with different ARD were enrolled for up to 20 gestational weeks in 29…
View article: P118 Increased atherothrombotic risk in SLE patients: the role of oxidative stress in fibrinogen structural and functional modifications
P118 Increased atherothrombotic risk in SLE patients: the role of oxidative stress in fibrinogen structural and functional modifications Open
Objective Patients with systemic lupus erythematosus (SLE) show accelerated atherosclerosis and are at higher risk of developing myocardial infarction, stroke and peripheral vasculopathy, carrying an overall 2- to 10-fold higher risk of ca…
View article: Statins, ACE/ARBs drug use, and risk of pneumonia in hospitalized older patients: a retrospective cohort study
Statins, ACE/ARBs drug use, and risk of pneumonia in hospitalized older patients: a retrospective cohort study Open
The aims of this study is to evaluate the association between angiotensin-converting enzyme inhibitor (ACE-I), angiotensin II receptor blocker (ARBs) and/or statin use with the risk of pneumonia, as well as and with in-hospital and short-t…
View article: Modulation of Gut Microbiota through Nutritional Interventions in Behçet’s Syndrome Patients: Preliminary Results from the MAMBA Study
Modulation of Gut Microbiota through Nutritional Interventions in Behçet’s Syndrome Patients: Preliminary Results from the MAMBA Study Open
Background. Recent evidence suggests that the gut microbiota (GM) in Behçet’s syndrome patients (BS) has low diversity and a peculiar layout. Diet is known to influence the GM, but to date no study has investigated its effect on these pati…
View article: SIRT1 and thrombosis
SIRT1 and thrombosis Open
Thrombosis is a major cause of morbidity and mortality worldwide, with a complex and multifactorial pathogenesis. Recent studies have shown that SIRT1, a member of the sirtuin family of NAD + -dependent deacetylases, plays a crucial role i…
View article: SARS-CoV-2 vaccination and risk of infectious diseases in hospitalized older patients
SARS-CoV-2 vaccination and risk of infectious diseases in hospitalized older patients Open
In older inpatients, SARS-CoV-2 vaccination seems to be associated with a lower likelihood of intra-hospital infectious diseases not caused by SARS-CoV-2 and all-cause in-hospital mortality. The vaccination coverage in the older population…
View article: A systematic review of real-world contact tracing strategies at the onset of the COVID-19 pandemic
A systematic review of real-world contact tracing strategies at the onset of the COVID-19 pandemic Open
Background Contact tracing (CT) represented one of the core activities for the prevention and control of COVID-19 in the early phase of the pandemic, before the availability of effective vaccines. Poor evidence is available on the real-wor…
View article: SARS-CoV-2 vaccination and risk of infectious diseases in hospitalized older patients
SARS-CoV-2 vaccination and risk of infectious diseases in hospitalized older patients Open
Purpose. Vaccinations, for example flu vaccine, may be a cause of cross-reactive immunostimulation that prevents a larger spectrum of infections. However, whether SARS-CoV-2 vaccinations may also determine this effect is unclear. This stud…
View article: Multimodal nonlinear correlates of behavioural symptoms in frontotemporal dementia
Multimodal nonlinear correlates of behavioural symptoms in frontotemporal dementia Open
Background Studies exploring the brain correlates of behavioural symptoms in the frontotemporal dementia spectrum (FTD) have mainly searched for linear correlations with single modality neuroimaging data, either structural magnetic resonan…
View article: Correction to: Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register
Correction to: Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register Open
View article: The new era of anticoagulation: factor XI and XII inhibitors
The new era of anticoagulation: factor XI and XII inhibitors Open
The two last decades have witnessed a revolution in the field of anticoagulation, mainly due to the advent of direct anticoagulant with targeted action against single coagulation proteins. However, the residual risk of cardio- and cerebrov…
View article: AB0431 CANAKINUMAB AS FIRST-LINE BIOLOGICAL THERAPY IN STILL'S DISEASE AND DIFFERENCES BETWEEN THE SYSTEMIC AND THE CHRONIC-ARTICULAR COURSES: REAL-LIFE EXPERIENCE FROM THE INTERNATIONAL AIDA REGISTRY
AB0431 CANAKINUMAB AS FIRST-LINE BIOLOGICAL THERAPY IN STILL'S DISEASE AND DIFFERENCES BETWEEN THE SYSTEMIC AND THE CHRONIC-ARTICULAR COURSES: REAL-LIFE EXPERIENCE FROM THE INTERNATIONAL AIDA REGISTRY Open
View article: POS1554 AN OBSERVATIONAL MULTICENTER STUDY COMPARING THE EFFECTIVENESS BETWEEN TNF INHIBITORS AND APREMILAST ON ORAL ULCERS OF BEHCET'S DISEASE
POS1554 AN OBSERVATIONAL MULTICENTER STUDY COMPARING THE EFFECTIVENESS BETWEEN TNF INHIBITORS AND APREMILAST ON ORAL ULCERS OF BEHCET'S DISEASE Open
View article: OP0304 BENRALIZUMAB FOR EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (EGPA): RESULTS FROM A EUROPEAN MULTICENTER STUDY ON 121 PATIENTS
OP0304 BENRALIZUMAB FOR EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (EGPA): RESULTS FROM A EUROPEAN MULTICENTER STUDY ON 121 PATIENTS Open
View article: AB0667 CHARACTERIZING ULTRASOUND-PROVEN ENTHESITIS IN SYSTEMIC LUPUS ERYTHEMATOSUS: PREVALENCE AND IDENTIFICATION OF DISEASE SUBSET WITH LESS FREQUENT RENAL INVOLVEMENT
AB0667 CHARACTERIZING ULTRASOUND-PROVEN ENTHESITIS IN SYSTEMIC LUPUS ERYTHEMATOSUS: PREVALENCE AND IDENTIFICATION OF DISEASE SUBSET WITH LESS FREQUENT RENAL INVOLVEMENT Open
View article: AB1632 PREVALENCE OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AT THE REFERRAL CENTERS IN ITALY: A MULTICENTER STUDY
AB1632 PREVALENCE OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AT THE REFERRAL CENTERS IN ITALY: A MULTICENTER STUDY Open
View article: AB0164 SERUM LEVELS OF INTERLEUKIN-36 Α TO DISTINGUISH BEHÇET'S SYNDROME AND PSORIATIC ARTHRITIS
AB0164 SERUM LEVELS OF INTERLEUKIN-36 Α TO DISTINGUISH BEHÇET'S SYNDROME AND PSORIATIC ARTHRITIS Open
View article: AB0798 PREVALENCE AND CLINICAL SPECTRUM OF CARDIAC INVOLVEMENT IN BEHÇET’S SYNDROME: A SINGLE CENTER RETROSPECTIVE STUDY
AB0798 PREVALENCE AND CLINICAL SPECTRUM OF CARDIAC INVOLVEMENT IN BEHÇET’S SYNDROME: A SINGLE CENTER RETROSPECTIVE STUDY Open
Background Behçet's Syndrome (BS) is a systemic vasculitis, which main clinical features include mucocutaneous manifestations, pan-uveitis, non-deforming arthritis, thrombosis, central nervous system (CNS) and gastrointestinal (GI) involve…
View article: Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis
Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis Open
Behçet’s syndrome (BS) is a rare systemic vasculitis characterized by different clinical manifestations. As no specific laboratory tests exist, the diagnosis relies on clinical criteria, and the differential diagnosis with other inflammato…