Irene Owusu Donkor
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View article: Pre-Clade IIb Mpox Virus Exposure in Ghana: A Retrospective Serological Analysis
Pre-Clade IIb Mpox Virus Exposure in Ghana: A Retrospective Serological Analysis Open
Monkeypox virus (MPXV), a zoonotic Orthopox virus endemic to West and Central Africa, causes mpox disease. Although Ghana had no confirmed human cases before 2022, the 2003 U.S. mpox outbreak was traced to rodents exported from Ghana, sugg…
View article: Immune imprinting and antibody profiles to SARS-CoV-2 in urban and rural Ghana
Immune imprinting and antibody profiles to SARS-CoV-2 in urban and rural Ghana Open
View article: Evaluation of SARS-CoV-2 Seroprevalence and Variant Distribution During the Delta–Omicron Transmission Waves in Greater Accra, Ghana, 2021
Evaluation of SARS-CoV-2 Seroprevalence and Variant Distribution During the Delta–Omicron Transmission Waves in Greater Accra, Ghana, 2021 Open
A significant proportion of SARS-CoV-2 infections in Africa were identified as asymptomatic. With the surge of the Omicron variant, asymptomatic participants in epidemiological surveys were key to accurately estimating seroprevalence and t…
View article: Emergence and spread of the SARS-CoV-2 omicron (BA.1) variant across Africa: an observational study
Emergence and spread of the SARS-CoV-2 omicron (BA.1) variant across Africa: an observational study Open
For the French, Portugese and Spanish translations of the abstract see Supplementary Materials section.
View article: Waning Trends in Prevalence and Intensity of Wuchereria bancrofti Transmission Over Ten Chemotherapy Rounds in Ghana
Waning Trends in Prevalence and Intensity of Wuchereria bancrofti Transmission Over Ten Chemotherapy Rounds in Ghana Open
Ghana’s lymphatic filariasis (LF) elimination was intensified by Global Programme to Eliminate Lymphatic filariasis in 2000. LF transmission was interrupted in some endemic district, yet, persistent in others. This study investigated some …
View article: Investigating Environmental Determinants of Hookworm Transmission using GPS Tracking and Metagenomics Technologies
Investigating Environmental Determinants of Hookworm Transmission using GPS Tracking and Metagenomics Technologies Open
To identify potential sources of hookworm infections in a Ghanaian community of endemicity that could be targeted to interrupt transmission, we tracked the movements of infected and noninfected persons to their most frequented locations. F…
View article: A Global Collaborative Comparison of SARS-CoV-2 Antigenicity Across 15 Laboratories
A Global Collaborative Comparison of SARS-CoV-2 Antigenicity Across 15 Laboratories Open
Setting up a global SARS-CoV-2 surveillance system requires an understanding of how virus isolation and propagation practices, use of animal or human sera, and different neutralisation assay platforms influence assessment of SARS-CoV-2 ant…
View article: High abundance of butyrate-producing bacteria in the naso-oropharynx of SARS-CoV-2-infected persons in an African population: implications for low disease severity
High abundance of butyrate-producing bacteria in the naso-oropharynx of SARS-CoV-2-infected persons in an African population: implications for low disease severity Open
Background The association of the oral microbiome with SARS-CoV-2 infections and disease progression has been documented in European, Asian, and American populations but not in Africa. Methods We conducted a study in Ghana to evaluate and …
View article: Detection of SARS-CoV-2 Variants Imported Through Land Borders at the Height of the COVID-19 Pandemic in Ghana, 2022
Detection of SARS-CoV-2 Variants Imported Through Land Borders at the Height of the COVID-19 Pandemic in Ghana, 2022 Open
Background The World Health Organization recommends surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at points of entry to systematically collect and analyze data to inform decisions about the effective and appr…
View article: Ineffectiveness of international travel restrictions to contain spread of the SARS-CoV-2 Omicron BA.1 variant: a continent-wide laboratory-based observational study from Africa
Ineffectiveness of international travel restrictions to contain spread of the SARS-CoV-2 Omicron BA.1 variant: a continent-wide laboratory-based observational study from Africa Open
Background: In mid-November 2021, the SARS-CoV-2 Omicron BA.1 variant was detected in Southern Africa, prompting international travel restrictions of unclear effectiveness that exacted a substantial economic toll. Methods: Amidst the BA.1 …
View article: dilemma of chronic kidney disease of unknown origin
dilemma of chronic kidney disease of unknown origin Open
Over the past two decades, cumulative increases in the prevalence of chronic kidney disease (CKD) have been observed in selected geographic areas in several countries. The etiology of this CKD cannot be attributed to known or traditional c…
View article: Assessing the performance of regular surgical nose masks as a sampling method for SARS-CoV-2 detection in a cross-sectional study
Assessing the performance of regular surgical nose masks as a sampling method for SARS-CoV-2 detection in a cross-sectional study Open
Nose masks are widely worn for protection against respiratory pathogens, including SARS-CoV-2. They have been reported as possible substrates for viral sampling and testing for COVID-19 but, evaluations have so far been purposive; involvin…
View article: Short communication—Lessons learnt during the implementation of Unity‐aligned SARS‐CoV‐2 seroprevalence studies in Africa
Short communication—Lessons learnt during the implementation of Unity‐aligned SARS‐CoV‐2 seroprevalence studies in Africa Open
The WHO Unity Studies initiative engaged low‐ and middle‐income countries in the implementation of standardised SARS‐CoV‐2 sero‐epidemiological investigation protocols and timely sharing of comparable results for evidence‐based action. To …
View article: Investigating Environmental Determinants of Soil-Transmitted Helminths Transmission using GPS Tracking and Metagenomics Technologies
Investigating Environmental Determinants of Soil-Transmitted Helminths Transmission using GPS Tracking and Metagenomics Technologies Open
Background The Global Health community aims to eliminate soil-transmitted helminth (STH) infections by 2030. Current preventive methods such as Mass Drug Administration, WASH practices, and health education needs to be complimented to halt…
View article: Development of an Affordable ELISA Targeting the SARS-CoV-2 Nucleocapsid and Its Application to Samples from the Ongoing COVID-19 Epidemic in Ghana
Development of an Affordable ELISA Targeting the SARS-CoV-2 Nucleocapsid and Its Application to Samples from the Ongoing COVID-19 Epidemic in Ghana Open
Introduction The true nature of the population spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in populations is often not fully known as most cases, particularly in Africa, are asymptomatic. Finding the true magnitu…
View article: Modeling SARS-CoV-2 antibody seroprevalence and its determinants in Ghana: A nationally representative cross-sectional survey
Modeling SARS-CoV-2 antibody seroprevalence and its determinants in Ghana: A nationally representative cross-sectional survey Open
Estimates of SARS-CoV-2 transmission rates have significant public health policy implications since they shed light on the severity of illness in various groups and aid in strategic deployment of diagnostics, treatment and vaccination. Pop…
View article: Short Communication - Lessons learnt during the implementation of Unity-aligned SARS-CoV-2 seroprevalence studies in Africa
Short Communication - Lessons learnt during the implementation of Unity-aligned SARS-CoV-2 seroprevalence studies in Africa Open
The WHO Unity Studies initiative engaged low- and middle-income countries in the implementation of standardized SARS-CoV-2 sero-epidemiological investigation protocols and timely sharing of comparable results for evidence-based action. To …
View article: Mpox: Seroepidemiology and risk factors amidst increasing cases in Ghana
Mpox: Seroepidemiology and risk factors amidst increasing cases in Ghana Open
Withdrawal Statement The authors have withdrawn their manuscript to run confirmatory assays to confirm the initial results obtained. Therefore, the authors do not wish this work to be cited as a reference for the project. If you have anyqu…
View article: RETRACTED: Gradual emergence followed by exponential spread of the SARS-CoV-2 Omicron variant in Africa
RETRACTED: Gradual emergence followed by exponential spread of the SARS-CoV-2 Omicron variant in Africa Open
The geographic and evolutionary origins of the SARS-CoV-2 Omicron variant (BA.1), which was first detected mid-November 2021 in Southern Africa, remain unknown. We tested 13,097 COVID-19 patients sampled between mid-2021 to early 2022 from…
View article: Determination of SARS-CoV-2 Variants and Seroprevalence in Accra, Ghana during the Delta-Omicron Waves
Determination of SARS-CoV-2 Variants and Seroprevalence in Accra, Ghana during the Delta-Omicron Waves Open
A significant proportion of SARS-CoV-2 infections in Africa are identified as asymptomatic, facilitating the silent spread of the virus especially in populated urban cities. With the surge of the highly transmissible Omicron variant, the i…
View article: OraSure InteliSwab™ Rapid Antigen Test Performance with the SARS-CoV-2 Variants of Concern—Alpha, Beta, Gamma, Delta, and Omicron
OraSure InteliSwab™ Rapid Antigen Test Performance with the SARS-CoV-2 Variants of Concern—Alpha, Beta, Gamma, Delta, and Omicron Open
The emergence of SARS-CoV-2 in the human population and the resulting COVID-19 pandemic have led to the development of various diagnostic tests. The OraSure InteliSwab™ COVID-19 Rapid Test is a recently developed and FDA emergency use-auth…
View article: OraSure InteliSwab<sup>®</sup> Rapid Antigen Test performance with the SARS-CoV-2 Variants of Concern Alpha, Beta, Gamma, Delta, and Omicron
OraSure InteliSwab<sup>®</sup> Rapid Antigen Test performance with the SARS-CoV-2 Variants of Concern Alpha, Beta, Gamma, Delta, and Omicron Open
The emergence of SARS-CoV-2 in the human population and the resulting COVID-19 pandemic has led to the development of various diagnostic tests. The OraSure InteliSwab ® COVID-19 Rapid Test is a recently developed and FDA emergency use auth…
View article: Modeling SARS-CoV-2 Antibody Seroprevalence and its Determinants in Ghana: A Nationwide Cross-Sectional Survey
Modeling SARS-CoV-2 Antibody Seroprevalence and its Determinants in Ghana: A Nationwide Cross-Sectional Survey Open
View article: OraSure InteliSwab™ Rapid Antigen Test performance with the SARS-CoV-2 Variants of Concern Alpha, Beta, Gamma, Delta, and Omicron
OraSure InteliSwab™ Rapid Antigen Test performance with the SARS-CoV-2 Variants of Concern Alpha, Beta, Gamma, Delta, and Omicron Open
A study to assess the performance of OraSure InteliSwab™ Rapid Antigen Test with the SARS-CoV-2 Variants of Concern Alpha, Beta, Gamma, Delta, and Omicron.
View article: SARS CoV2 Seroprevalence in Rural and Urban Populations In Ghana
SARS CoV2 Seroprevalence in Rural and Urban Populations In Ghana Open
Results of population-based age stratified seroepidemiological investigation in Ghana
View article: SARS CoV2 Seroprevalence in Rural and Urban Populations In Ghana
SARS CoV2 Seroprevalence in Rural and Urban Populations In Ghana Open
Results of population-based age stratified seroepidemiological investigation in Ghana
View article: SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamsters
SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamsters Open
View article: K18-hACE2 mice develop respiratory disease resembling severe COVID-19
K18-hACE2 mice develop respiratory disease resembling severe COVID-19 Open
SARS-CoV-2 emerged in late 2019 and resulted in the ongoing COVID-19 pandemic. Several animal models have been rapidly developed that recapitulate the asymptomatic to moderate disease spectrum. Now, there is a direct need for additional sm…
View article: SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamsters
SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamsters Open
SARS-CoV-2 transmission in hamsters showing that disease severity and transmission efficiency is routes of transmission dependent.
View article: SARS-CoV-2 disease severity and transmission efficiency is increased for airborne but not fomite exposure in Syrian hamsters
SARS-CoV-2 disease severity and transmission efficiency is increased for airborne but not fomite exposure in Syrian hamsters Open
Transmission of SARS-CoV-2 is driven by contact, fomite, and airborne transmission. The relative contribution of different transmission routes remains subject to debate. Here, we show Syrian hamsters are susceptible to SARS-CoV-2 infection…