Irene Zecchino
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View article: The role of the intestinal microbiome in cognitive decline in patients with kidney disease
The role of the intestinal microbiome in cognitive decline in patients with kidney disease Open
Cognitive decline is frequently seen in patients with chronic kidney disease (CKD). The causes of cognitive decline in these patients are likely to be multifactorial, including vascular disease, uraemic toxins, blood–brain barrier leakage,…
View article: Cognitive impairment in kidney transplanted patients
Cognitive impairment in kidney transplanted patients Open
Chronic kidney disease affects almost all of the organs. Recently, more attention has been paid to the kidney and the central nervous system connections. In patients on kidney replacement therapy, including kidney transplantation, there is…
View article: Care pathways for patients with cognitive impairment and chronic kidney disease
Care pathways for patients with cognitive impairment and chronic kidney disease Open
Various epidemiological datasets and pathophysiological hypotheses have highlighted a significant link between chronic kidney disease (CKD) and cognitive impairment (CI); each condition can potentially exacerbate the other. Here, we review…
View article: CONNECT: what has been done and what needs to be done
CONNECT: what has been done and what needs to be done Open
View article: Chemotherapy-related cognitive impairment and kidney dysfunction
Chemotherapy-related cognitive impairment and kidney dysfunction Open
Cancer and kidney diseases (KD) intersect in many ways resulting in worse outcomes. Both conditions are correlated with cognitive impairment, which can be exacerbated in cancer patients by known effects of many antineoplastic drugs on cogn…
View article: Genetic and circulating biomarkers of cognitive dysfunction and dementia in CKD
Genetic and circulating biomarkers of cognitive dysfunction and dementia in CKD Open
Chronic kidney disease (CKD) is commonly accompanied by cognitive dysfunction and dementia, which, in turn, increase the risk of hospitalization, cardiovascular events and death. Over the last 30 years, only four studies focused on genetic…
View article: Big databases and biobanks for studying the links between CKD, cognitive impairment, and dementia
Big databases and biobanks for studying the links between CKD, cognitive impairment, and dementia Open
Research on cognitive function in individuals with chronic kidney disease (CKD) is critical due to the significant public health challenge posed by both CKD and cognitive impairment. CKD affects approximately 10–15% of the adult population…
View article: Cognitive impairment in chronic kidney disease: role of brain imaging, functional imaging, electroencephalography, cerebrospinal fluid biomarkers and sensors
Cognitive impairment in chronic kidney disease: role of brain imaging, functional imaging, electroencephalography, cerebrospinal fluid biomarkers and sensors Open
Chronic kidney disease is associated with cognitive impairment although the underlying mechanisms are still not fully understood. Characterization and efficient monitoring of the cognitive impact of kidney disease and ensuing therapies are…
View article: Cholinergic system in patients with chronic kidney disease: cognitive and renal implications
Cholinergic system in patients with chronic kidney disease: cognitive and renal implications Open
Cholinergic synapses are widespread throughout the human central nervous system. Their high density in the thalamus, neocortex, limbic system and striatum suggests that cholinergic transmission plays a vital role in memory, attention, lear…
View article: Cognitive impairment in CKD patients: a guidance document by the CONNECT network
Cognitive impairment in CKD patients: a guidance document by the CONNECT network Open
Cognitive impairment is a prevalent and debilitating complication in patients with chronic kidney disease (CKD). This position paper, developed by the Cognitive Decline in Nephro-Neurology: European Cooperative Target network, provides gui…
View article: Drugs with a negative impact on cognitive functions (part 3): antibacterial agents in patients with chronic kidney disease
Drugs with a negative impact on cognitive functions (part 3): antibacterial agents in patients with chronic kidney disease Open
The relationship between chronic kidney disease (CKD) and cognitive function has received increased attention in recent years. Antibacterial agents (ABs) represent a critical component of therapy regimens in patients with CKD due to increa…
View article: Cognitive decline related to chronic kidney disease as an exclusion factor from kidney transplantation: results from an international survey
Cognitive decline related to chronic kidney disease as an exclusion factor from kidney transplantation: results from an international survey Open
Background and hypothesis There seems to be a lack of consensus on the necessity and the modality of psychological and specifically cognitive assessment of candidates for kidney transplantation. Both points are often delegated to individua…
View article: The need for a multi-disciplinary reflection about frailty and cognitive impairment in chronic kidney disease
The need for a multi-disciplinary reflection about frailty and cognitive impairment in chronic kidney disease Open
This Editorial outlines the need for a multidisciplinary reflection about the impact of chronic kidney disease on cognitive impairment and its implications for ethically salient notions, like self-determination and autonomy.