Irfan Aamer Ansari
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View article: Quercetin modulates the anti-arthritic effects of indomethacin, possibly through COXs and TNF-α interaction pathways
Quercetin modulates the anti-arthritic effects of indomethacin, possibly through COXs and TNF-α interaction pathways Open
Quercetin (QUR) is a flavonoid compound with potent anti-oxidant and anti-inflammatory properties, commonly found in various fruits and vegetables. This study aims to evaluate the synergistic anti-arthritic effects of QUR in combination wi…
View article: D-pinitol modulates the anti-emetic effects of aprepitant, domperidone, and ondansetron in chicks
D-pinitol modulates the anti-emetic effects of aprepitant, domperidone, and ondansetron in chicks Open
Naturally occurring substance, D-pinitol (DPL) belongs to the significant inositol family has numerous pharmacological activity. In this study we evaluated the anti-emetic effect as well as modulation activities of DPL on the recent market…
View article: Assessment of Antihyperglycemic and Modulatory Effects of <i>trans</i> ‐Ferulic Acid on Glibenclamide and Metformin: In Vivo and Molecular Docking Studies
Assessment of Antihyperglycemic and Modulatory Effects of <i>trans</i> ‐Ferulic Acid on Glibenclamide and Metformin: In Vivo and Molecular Docking Studies Open
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia due to impaired insulin secretion, insulin resistance, or both. trans ‐Ferulic acid (TFA) has several biological activities, including sedativ…
View article: Sesamol exerts’ anti-inflammatory effect and synergistic properties with celecoxib and ketoprofen in broiler chicks possibly through COXs interaction pathway
Sesamol exerts’ anti-inflammatory effect and synergistic properties with celecoxib and ketoprofen in broiler chicks possibly through COXs interaction pathway Open
View article: Possible <scp>GABAkine</scp>‐Mediated Sedative‐Like Antidepressant Effects of Phytol: Molecular Interventions Through In Vitro, In Vivo and In Silico Approaches
Possible <span>GABAkine</span>‐Mediated Sedative‐Like Antidepressant Effects of Phytol: Molecular Interventions Through In Vitro, In Vivo and In Silico Approaches Open
Background A previous report suggests that phytol (PHY) may exert its antidepressant effects in mice, possibly through GABA A receptor interaction pathways. Aim We aimed to check its antidepressant effect with possible molecular mechanisms…
View article: Citronellal Exerts Sedative‐ <i>Like</i> Effects and Augments Diazepam's Action in <i>Swiss</i> Mice, Possibly Through the GABAergic Pathway
Citronellal Exerts Sedative‐ <i>Like</i> Effects and Augments Diazepam's Action in <i>Swiss</i> Mice, Possibly Through the GABAergic Pathway Open
Introduction Citronellal (CTL), a monoterpenoid, exhibits notable neurological activity, including anxiolytic, and anticonvulsant effects, primarily through GABAergic pathways. Our current study aimed to explore CTL's sedative potential us…
View article: <i>trans</i>‐Ferulic Acid Antagonizes the Anti‐Inflammatory Activity of Etoricoxib: Possible Interaction of COX‐1 and NOS
<i>trans</i>‐Ferulic Acid Antagonizes the Anti‐Inflammatory Activity of Etoricoxib: Possible Interaction of COX‐1 and NOS Open
This study emphasizes to investigate the modulatory activity of trans ‐ferulic acid (TFA) on anti‐inflammatory activity of etoricoxib (ETO) and underlying mechanisms via formalin‐induced licking and paw edema model and in silico study. Inf…
View article: GABAergic anti-convulsion prospects of thymol through in vivo and in silico studies
GABAergic anti-convulsion prospects of thymol through in vivo and in silico studies Open
The thyme monoterpenoid phenol thymol (THY) possesses diverse biological activities, including anti-convulsant effects. However, the possible action mechanism behind this fact has yet to be discovered. This study aimed to evaluate the anti…
View article: Assessment of clot-lysing and membrane-stabilizing capacity of ascorbic acid: In vitro approach with molecular docking
Assessment of clot-lysing and membrane-stabilizing capacity of ascorbic acid: In vitro approach with molecular docking Open
This study aimed to evaluate the clot-lysing and membrane stabilizing capacities of ascorbic acid (AA) using in vitro and in silico methods. For this, we used in vitro clot lysis and hemolyzing tests to check the anti-…
View article: Protodioscin exerts antagonistic analgesic and antidiarrheal properties through the cyclooxygenase and µ-opioid receptor interaction pathways
Protodioscin exerts antagonistic analgesic and antidiarrheal properties through the cyclooxygenase and µ-opioid receptor interaction pathways Open
Protodioscin (PRO), a natural steroidal saponin, shows potential for treating pain and diarrhea due to its anti-inflammatory and analgesic properties. The study aims to investigate the analgesic and antidiarrheal effects of PRO, comparing …
View article: Synergistic Antiemetic Effects of Nerolidol on Domperidone, Hyoscine, and Ondansetron: <i>In Vivo</i> and <i>in Silico</i> Investigations on Receptor Binding Affinity
Synergistic Antiemetic Effects of Nerolidol on Domperidone, Hyoscine, and Ondansetron: <i>In Vivo</i> and <i>in Silico</i> Investigations on Receptor Binding Affinity Open
The present study was designed to measure the potential antiemetic properties of nerolidol (NDL) via in vivo and in silico studies. To induce emesis copper sulfate pentahydrate (CuSO 4 .5H 2 O) was administered at a dose of 50 mg/kg (orall…
View article: Qualitative Phytochemical Analysis and Assessments of Analgesic and Antidiarrheal Activity of the Methanolic Leaf Extract of <i>Cheilanthes tenuifolia</i> : In Vivo Study
Qualitative Phytochemical Analysis and Assessments of Analgesic and Antidiarrheal Activity of the Methanolic Leaf Extract of <i>Cheilanthes tenuifolia</i> : In Vivo Study Open
Background Cheilanthes tenuifolia (Burm.f.), commonly known as the Sword Fern or Narrow‐leaved Cloak Fern, is a little evergreen fern that belongs to the Pteridaceae family and is abundant in various bioactive compounds exerting promising …
View article: Anxiolytic Efficacy of Indirubin: <i>In Vivo</i> Approach Along with Receptor Binding Profiling and Molecular Interaction with GABAergic Pathways
Anxiolytic Efficacy of Indirubin: <i>In Vivo</i> Approach Along with Receptor Binding Profiling and Molecular Interaction with GABAergic Pathways Open
Anxiety is a natural response to stress, characterized by feelings of worry, fear, or unease. The current research was conducted to investigate the anxiolytic effect of indirubin (IND) in different behavioral paradigms in Swiss albino mice…
View article: Exploring the antiemetic potential of ascorbic acid: a combined animal behavior and in silico approach targeting 5-HT 3 and D2 receptors
Exploring the antiemetic potential of ascorbic acid: a combined animal behavior and in silico approach targeting 5-HT 3 and D2 receptors Open
Emesis, or vomiting, is a reflex involving the forceful expulsion of stomach contents, often triggered by various physiological and psychological factors. The current study was conducted to evaluate the antiemetic properties of ascorbic ac…
View article: Piperine exerts anti-inflammatory effects and antagonises the properties of celecoxib and ketoprofen: <i>in vivo</i> and molecular docking studies
Piperine exerts anti-inflammatory effects and antagonises the properties of celecoxib and ketoprofen: <i>in vivo</i> and molecular docking studies Open
This study evaluates the anti-inflammatory effects of a natural product, piperine (PPN), using in vivo and in silico methodologies. In the in vivo segment, inflammation was induced in the right hind paw of young chicks…
View article: Caffeine and sclareol reduce the sedative effects of linalool, possibly through the GABA A interaction pathway: molecular insights through in vivo and in silico studies
Caffeine and sclareol reduce the sedative effects of linalool, possibly through the GABA A interaction pathway: molecular insights through in vivo and in silico studies Open
Study background: Linalool (LIN) has some important neuropharmacological activities, including anxiolytic and sedative effects. It is also clear that it protects experimental animals from convulsions and Alzheimer's disease. On the other h…
View article: Piperine’s potential in treating polycystic ovarian syndrome explored through in-silico docking
Piperine’s potential in treating polycystic ovarian syndrome explored through in-silico docking Open
Polycystic Ovarian Syndrome (PCOS) is a multifaceted metabolic and hormonal condition that impacts women in their procreative ages, identified by ovarian dysfunction, hyperandrogenaemia overweight and insulin insensitivity. The piperine, a…
View article: Phytochemical Screening and Pharmacological Investigations of Curculigo orchioides Leaf Extracts
Phytochemical Screening and Pharmacological Investigations of Curculigo orchioides Leaf Extracts Open
Curculigo orchioides Gaertn. (C. orchioides) is commonly known as Talamuli in Bangladesh. It is commonly distributed in Asian countries. The Indian (Ayurvedic) and Chinese traditional medicine systems use this plant frequently as an aphrod…
View article: Possible GABAkine-mediated antidepressant effects of phytol: molecular interventions through in vivo and in silico studies
Possible GABAkine-mediated antidepressant effects of phytol: molecular interventions through in vivo and in silico studies Open
Phytol (PHY), a chlorophyll side chain diterpenoid possesses many health benefits, including neurological activities. A previous report evaluated its anti-depressive effects in mice without any possible mechanism. Our current study aimed a…
View article: Anti-inflammatory effects of thymol: an emphasis on the molecular interactions through in vivo approach and molecular dynamic simulations
Anti-inflammatory effects of thymol: an emphasis on the molecular interactions through in vivo approach and molecular dynamic simulations Open
Thymol (THY), as the natural monoterpene phenol, acts against oxidative stress and inflammatory processes. This study aimed to evaluate the anti-inflammatory effects and possible molecular mechanisms of THY via formalin-induced mouse and e…
View article: Possible hemoglobin enhancing effect of phytol in methotrexate-induced folate deficient Swiss albino mice: In vivo and in silico studies
Possible hemoglobin enhancing effect of phytol in methotrexate-induced folate deficient Swiss albino mice: In vivo and in silico studies Open
The diterpenoid phytol is evidently acting against anemia in experimental animals. However, the molecular mechanisms behind this issue are yet to be discovered. This study aimed to evaluate phytol's effect on methotrexate-induced folate-de…
View article: Exploring Piperine as a Potential Treatment for Polycystic Ovarian Syndrome: Insights from In-silico Docking Studies
Exploring Piperine as a Potential Treatment for Polycystic Ovarian Syndrome: Insights from In-silico Docking Studies Open
Polycystic Ovarian Syndrome (PCOS) is a multifaceted metabolic and hormonal condition that impacts women in their procreative ages, identified by ovarian dysfunction, hyperandrogenaemiaoverweight and insulin insensitivity.The piperine, an …
View article: Investigating the potential of Fourier transform mid-infrared spectroscopy combined with chemometrics for detecting camel’s milk adulteration
Investigating the potential of Fourier transform mid-infrared spectroscopy combined with chemometrics for detecting camel’s milk adulteration Open
This study explores the effectiveness of mid-infrared (MIR) spectroscopy in combination with chemometrics as an alternative to sensory analysis for detecting camel’s milk adulteration with cow’s milk. A paired comparison test involving var…
View article: Antiemetic activity of abietic acid possibly through the 5HT3 and muscarinic receptors interaction pathways
Antiemetic activity of abietic acid possibly through the 5HT3 and muscarinic receptors interaction pathways Open
The present study was designed to evaluate the antiemetic activity of abietic acid (AA) using in vivo and in silico studies. To assess the effect, doses of 50 mg/kg b.w. copper sulfate (CuSO 4 ⋅5H 2 O) were given orally to 2-day-old chicks…
View article: Screening of Multitarget Compounds against Acetaminophen Hepatic Toxicity Using In Silico, In Vitro, and In Vivo Approaches
Screening of Multitarget Compounds against Acetaminophen Hepatic Toxicity Using In Silico, In Vitro, and In Vivo Approaches Open
Combination therapy and multitarget drugs have recently attracted much attention as promising tools to fight against many challenging diseases and, thus, represent a new research focus area. The aim of the current project was to screen mul…
View article: Beneficial Bacteria for the Biodegradation of Polyethylene Teraphthalate Microplastics from Isolated from Seawater
Beneficial Bacteria for the Biodegradation of Polyethylene Teraphthalate Microplastics from Isolated from Seawater Open
View article: Gauging Quince Phytonutrients and Its 4% Emulgel Effect on Amplifying Facial Skin Moisturizing Potential
Gauging Quince Phytonutrients and Its 4% Emulgel Effect on Amplifying Facial Skin Moisturizing Potential Open
Background: The aim of this study was to evaluate the moisturizing efficacy of quince fruit, used in folk medicine. For this purpose, the phytoconstituents of Cydonia oblonga fruit extract, like phenolics and flavonoids, were determined. A…
View article: Spilanthes acmella Extract-Based Natural Oils Loaded Emulgel for Anti-Microbial Action against Dermatitis
Spilanthes acmella Extract-Based Natural Oils Loaded Emulgel for Anti-Microbial Action against Dermatitis Open
Background: Dermatitis is skin disorder that is complicated by recurrent infections of skin by bacteria, viruses, and fungi. Spilanthol is an active constituent of Spilanthes acmella, which possess strong anti-bacterial properties. The pur…
View article: Assessing the In Vitro and In Vivo Performance of L-Carnitine-Loaded Nanoparticles in Combating Obesity
Assessing the In Vitro and In Vivo Performance of L-Carnitine-Loaded Nanoparticles in Combating Obesity Open
Addressing obesity is a critical health concern of the century, necessitating urgent attention. L-carnitine (LC), an essential water-soluble compound, plays a pivotal role in lipid breakdown via β-oxidation and facilitates the transport of…
View article: Anxiolytic-like Effects by trans-Ferulic Acid Possibly Occur through GABAergic Interaction Pathways
Anxiolytic-like Effects by trans-Ferulic Acid Possibly Occur through GABAergic Interaction Pathways Open
Numerous previous studies reported that ferulic acid exerts anxiolytic activity. However, the mechanisms have yet to be elucidated. The current study aimed to investigate the anxiolytic effect of trans-ferulic acid (TFA), a stereoisomer of…