Explanipedia

Assessing of Pfdhps Gene of Sulfadoxine after Five Years of Seasonal Malaria Chemoprevention Implementation at Two Rural Sites in Mali: The Quantitative Method Open

Hamma Maiga, Robert Morrison, Issaka Sagara, Jennifer Hume, Sara A. Healy , et al. · 2025

Humoral Immunity Profiling to Pandemic and Bat‐Derived Coronavirus Variants: A Geographical Comparison Open

Parinaz Fathi, Andrea Lucia Alfonso, Christina Yek, Zoe Putman, Matthew Drew , et al. · 2024

Dynamic pathogen exposure may impact the immunological response to SARS‐CoV‐2 (SCV2). One potential explanation for the lack of severe SCV2‐related morbidity and mortality in Southeast Asia is prior exposure to related betacoronaviruses. R…

Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine Open

Rui Ma, Nichole D. Salinas, Sachy Orr-Gonzalez, Brandi Richardson, Tarik Ouahes , et al. · 2024

Placental accumulation of Plasmodium falciparum infected erythrocytes results in maternal anemia, low birth weight, and pregnancy loss. The parasite protein VAR2CSA facilitates the accumulation of infected erythrocytes in the placenta thro…

Safety and protective efficacy of PfSPZ Vaccine administered to HIV-negative and -positive Tanzanian adults Open

Said Jongo, L. W. Preston Church, Florence A. Milando, Munira Qassim, Tobias Schindler , et al. · 2024

BACKGROUNDSanaria PfSPZ Vaccine, composed of attenuated Plasmodium falciparum (Pf) sporozoites (SPZ), protects against malaria. We conducted this clinical trial to assess the safety and efficacy of PfSPZ Vaccine in HIV-positive (HIV+) indi…

mRNA vaccines expressing malaria transmission-blocking antigens Pfs25 and Pfs230D1 induce a functional immune response Open

Puthupparampil V. Scaria, Nicole Roth, Kim Schwendt, Olga Muratova, Nada Alani , et al. · 2024

Protection from Malaria after Pre-Conception PfSPZ Vaccine Open

Halimatou Diawara, Sara A. Healy, Agnes Mwakingwe-Omari, Djibrilla Issiaka, Aye Diallo , et al. · 2024

Tracking SARS-CoV-2 seropositivity in rural communities using blood-fed mosquitoes: a proof-of-concept study Open

Benjamin J. Krajacich, Djibril Samaké, Adama Dao, Moussa Diallo, Zana L. Sanogo , et al. · 2023

Background The spread of SARS-CoV-2 cannot be well monitored and understood in areas without capacity for effective disease surveillance. Countries with a young population will have disproportionately large numbers of asymptomatic or pauci…

Malaria transmission-blocking vaccines Pfs230D1-EPA and Pfs25-EPA in Alhydrogel in healthy Malian adults; a phase 1, randomised, controlled trial Open

Issaka Sagara, Sara A. Healy, Mahamadoun H. Assadou, Mamady Koné, Bruce Swihart , et al. · 2023

Preclinical evaluations of Pfs25-EPA and Pfs230D1-EPA in AS01 for a vaccine to reduce malaria transmission Open

Kelly M. Rausch, Emma K. Barnafo, Lynn Lambert, Olga Muratova, J. Patrick Gorres , et al. · 2023

Malaria transmission-blocking vaccine candidates Pfs25-EPA and Pfs230D1-EPA target sexual stage development of Plasmodium falciparum parasites in the mosquito host, thereby reducing mosquito infectivity. When formulated on Alhydroge…

Tracking SARS-CoV-2 seropositivity in rural communities using blood-fed mosquitoes Open

Benjamin J. Krajacich, Djibril Samaké, Adama Dao, Moussa Diallo, Zana L. Sanogo , et al. · 2023

The spread of SARS-CoV-2 cannot be well monitored and understood in areas without capacity for effective disease surveillance. Countries with a young population will have disproportionately large numbers of asymptomatic or pauci-symptomati…

366. Optimization of a Surrogate Assay for Efficacy of a Malaria Transmission Blocking Vaccine Open

Cristina Meehan, Cristina Meehan, Patrick Duffy, Jonathan P. Renn, Irfan Zaidi · 2022

Background An estimated 241 million malaria cases and 627,000 malaria deaths occurred worldwide in 2020. Efforts to develop a higher efficacy malaria vaccine are a global priority, but parasites pose a complex biological puzzle for vaccine…

Recent malaria does not substantially impact COVID-19 antibody response or rates of symptomatic illness in communities with high malaria and COVID-19 transmission in Mali, West Africa Open

John Woodford, Issaka Sagara, Halimatou Diawara, Mahamadoun H. Assadou, Abdoulaye Katilé , et al. · 2022

Malaria has been hypothesized as a factor that may have reduced the severity of the COVID-19 pandemic in sub-Saharan Africa. To evaluate the effect of recent malaria on COVID-19 we assessed a subgroup of individuals participating in a long…

SARS-CoV-2 Cross-Reactivity in Prepandemic Serum from Rural Malaria-Infected Persons, Cambodia Open

Jessica E. Manning, Irfan Zaidi, Chanthap Lon, Luz Angela Rosas, Jae-Keun Park , et al. · 2022

Inhabitants of the Greater Mekong Subregion in Cambodia are exposed to pathogens that might influence serologic cross-reactivity with severe acute respiratory syndrome coronavirus 2. A prepandemic serosurvey of 528 malaria-infected persons…

Assessing and Minimizing the Effect of Malaria on SARS-CoV-2 Serodiagnostics Open

John Woodford, Issaka Sagara, Jennifer Kwan, Irfan Zaidi, Alassane Dicko , et al. · 2021

Malaria may affect the reliability of SARS-CoV-2 seroassay performance and limit understanding of SARS-CoV-2 epidemiology in malaria-endemic regions. We present our experience conducting SARS-CoV-2 serosurveillance in seasonal malaria-affe…

Malaria transmission-blocking conjugate vaccine in ALFQ adjuvant induces durable functional immune responses in rhesus macaques Open

Puthupparampil V. Scaria, Charles Anderson, Olga Muratova, Nada Alani, Hung V. Trinh , et al. · 2021

PfSPZ Vaccine learns a lesson Open

Irfan Zaidi, Patrick E. Duffy · 2021

Safety and efficacy of a three-dose regimen of Plasmodium falciparum sporozoite vaccine in adults during an intense malaria transmission season in Mali: a randomised, controlled phase 1 trial Open

Mahamadou S. Sissoko, Sara A. Healy, Abdoulaye Katilé, Irfan Zaidi, Zonghui Hu , et al. · 2021

Severe Acute Respiratory Syndrome Coronavirus 2 Seroassay Performance and Optimization in a Population With High Background Reactivity in Mali Open

John Woodford, Issaka Sagara, Alassane Dicko, Amatigué Zéguimé, M’Bouye Doucoure , et al. · 2021

Background False positivity may hinder the utility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological tests in sub-Saharan Africa. Methods From 312 Malian samples collected before 2020, we measured antibodies to th…

Pre-pandemic SARS-CoV-2 serological reactivity in rural malaria-experienced Cambodians Open

Jessica E. Manning, Irfan Zaidi, Chanthap Lon, Luz Angela Rosas, Jae-Keun Park , et al. · 2021

Greater Mekong inhabitants are exposed to pathogens, zoonotic and otherwise, that may influence SARS-CoV-2 seroreactivity. A pre-pandemic (2005 to 2011) serosurvey of from 528 malaria-experienced Cambodians demonstrated higher-than-expecte…

Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity Open

Agnes Mwakingwe-Omari, Sara A. Healy, Jacquelyn Lane, David M. Cook, Sahand Kalhori , et al. · 2021

Rapidly Increasing Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence and Limited Clinical Disease in 3 Malian Communities: A Prospective Cohort Study Open

Issaka Sagara, John Woodford, Mamady Koné, Mahamadoun H. Assadou, Abdoulaye Katilé , et al. · 2021

Background The extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure and transmission in Mali and the surrounding region is not well understood. We aimed to estimate the cumulative incidence of SARS-CoV-2 in 3 com…

Rapidly increasing SARS-CoV-2 seroprevalence and limited clinical disease in three Malian communities: a prospective cohort study Open

Issaka Sagara, John Woodford, Mamady Koné, Mahamadoun H. Assadou, Abdoulaye Katilé , et al. · 2021

Background The extent of SARS-CoV-2 exposure and transmission in Mali and the surrounding region is not well understood, although infection has been confirmed in nearly 14,000 symptomatic individuals and their contacts since the first case…

SARS-CoV-2 seroassay optimization and performance in a population with high background reactivity in Mali Open

Issaka Sagara, John Woodford, Alassane Dicko, Amatigué Zéguimé, M’Bouye Doucoure , et al. · 2021

Serological tests are an indispensable tool to understand the epidemiology of the SARS-CoV-2 pandemic, particularly in areas where molecular diagnostics are limited. Poor assay performance may hinder the utility of these tests, including h…

Pfs230 yields higher malaria transmission–blocking vaccine activity than Pfs25 in humans but not mice Open

Sara A. Healy, Charles Anderson, Bruce Swihart, Agnes Mwakingwe, Erin E. Gabriel , et al. · 2021

BACKGROUNDVaccines that block human-to-mosquito Plasmodium transmission are needed for malaria eradication, and clinical trials have targeted zygote antigen Pfs25 for decades. We reported that a Pfs25 protein-protein conjugate vaccine form…

SARS-CoV-2 Seroassay Optimization and Performance in a Population with High Background Reactivity in Mali Open

John Woodford, Issaka Sagara, Jennifer Kwan, Amatigué Zéguimé, Irfan Zaidi , et al. · 2021

Pfs230 yields higher malaria transmission-blocking vaccine activity than Pfs25 in humans but not mice Open

Sara A. Healy, Charles Anderson, Bruce Swihart, Agnes Mwakingwe, Erin E. Gabriel , et al. · 2020

Background Vaccines that block human-to-mosquito Plasmodium transmission are needed for malaria eradication and clinical trials have targeted zygote antigen Pfs25 for decades. We reported that a Pfs25 protein-protein conjugate vaccine form…

Comparison of carrier proteins to conjugate malaria transmission blocking vaccine antigens, Pfs25 and Pfs230 Open

Puthupparampil V. Scaria, Beth B. Chen, Christopher G. Rowe, Nada Alani, Olga Muratova , et al. · 2020

Effect of Seasonal Malaria Chemoprevention on Immune Markers of Exhaustion and Regulation Open

Oumar Attaher, Irfan Zaidi, Jennifer Kwan, Djibrilla Issiaka, Mamoudou B Samassekou , et al. · 2019

Background Seasonal malaria chemoprevention (SMC) is a novel strategy to reduce malaria infections in children. Infection with Plasmodium falciparum results in immune dysfunction characterized by elevated expression of markers associated w…

Outer membrane protein complex as a carrier for malaria transmission blocking antigen Pfs230 Open

Puthupparampil V. Scaria, Christopher G. Rowe, Beth B. Chen, Olga Muratova, Elizabeth R. Fischer , et al. · 2019

Longitudinal analysis of gamma delta T cell subsets during malaria infections in Malian adults Open

Hama Diallo, Abdoulaye Katilé, Jennifer Kwan, Mahamadou S. Sissoko, Sara A. Healy , et al. · 2019

γδ T cells increased during a malaria transmission season and this expansion was noted in both the Vδ2+ and Vδ2- γδ T cells. However, neither expansion or activation of either γδ T cell subsets discriminated study participants that had asy…

Irfan Zaidi YOU? Author Swipe