Explanipedia

OR12-04 Clofutriben, an 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor, vs Placebo in a Phase II Trial for ACTH-dependent Cushing’s Syndrome (RESCUE) Open

Maria Fleseriu, Corin P Badiu, Irina Bancos, Eliza B. Geer, Maria Orbetzova , et al. · 2025

Disclosure: M. Fleseriu: None. C.P. Badiu: None. I. Bancos: None. E.B. Geer: None. M. Orbetzova: None. J.M. Silverstein: None. I. Uzunova: None. K.C. Yuen: None. T.K. Marmon: None. D.A. Katz: None. F.S. Czerwiec: None. Introduction: 11β-hy…

OR18-05 Sleep Disturbances In Patients With Cushing Syndrome and Mild Autonomous Cortisol Secretion: A Cross-Sectional Study Open

Shubhangi Sharma Sharma, Jasmine Saini, Shireen Renate Chacko, Sarina Ahmadian, Vanessa Fell , et al. · 2025

Disclosure: S. Sharma Sharma: None. J. Saini: None. S.R. Chacko: None. S. Ahmadian: None. V. Fell: None. S.J. Achenbach: None. E.J. Atkinson: None. W.F. Young: None. I. Bancos: None. Context: The impact of active hypercortisolism on sleep …

SUN-473 Clinical Utility of the 8-Mg-Dexamethasone Suppression Test in Assessing Hypercortisolism Open

Mahdi Salehi, Kai Yu, Camila A Villavicencio Torres, Vanessa Fell, Irina Bancos · 2025

Disclosure: M. Salehi: None. K. Yu: None. C.A. Villavicencio Torres: None. V. Fell: None. I. Bancos: None. Context: The use of the 1 mg overnight dexamethasone suppression test (1 mg-DST) is considered the standard-of-care test for the ass…

SAT-480 Comparison Of Sleep Disturbances In Patients With Mild Autonomous Cortisol Secretion (MACS) And Referent Subjects: A Cross-sectional Study Open

Shubhangi Sharma Sharma, Jasmine Saini, Shireen Renate Chacko, Sarina Ahmadian, Vanessa Fell , et al. · 2025

Disclosure: S. Sharma Sharma: None. J. Saini: None. S.R. Chacko: None. S. Ahmadian: None. V. Fell: None. S. Achenbach: None. A. Peersen: None. E. Atkinson: None. W.F. Young: None. I. Bancos: None. Context: Patients with MACS demonstrate an…

SUN-447 Frailty Outcomes In Patients With Mild Autonomous Cortisol Secretion: Impact Of Adrenalectomy Vs. Conservative Management Open

Bahaa Salama, Mohamed Bassiony, Jasmine Saini, Prerna Dogra, Elizabeth J. Atkinson , et al. · 2025

Disclosure: B. Salama: None. M. Bassiony: None. J. Saini: None. P. Dogra: None. E. Atkinson: None. J. Larson: None. I. Vodanovic: None. D. Kastelan: None. D.A. Delivanis: None. J. Hubska: None. U. Ambroziak: None. I. Bancos: None. Backgrou…

OR16-08 Baxdrostat in Patients with Primary Aldosteronism: Results from the SPARK Phase 2 Trial Open

Irina Bancos, Anat Ben-Shlomo, Oksana Hamidi, Amir H. Hamrahian, Wenyu Huang , et al. · 2025

Disclosure: I. Bancos: AstraZeneca. A. Ben-Shlomo: AstraZeneca. O. Hamidi: Recordati Rare Diseases, Neurocrine Biosciences, Corcept Therapeutics, Crinetics, Camurus, Xeris. A. Hamrahian: AstraZeneca. W. Huang: None. L.S. Kirschner: Corcept…

SUN-448 Overnight Metyrapone Therapy in Patients with Mild Autonomous Cortisol Secretion (MACS): An Open-Label Phase 2 Clinical Trial Open

Shireen R Chacko, Cayse Powell, Brevin Ndovu, Elio Y Ferreira, Robert Rosenberg , et al. · 2025

Disclosure: S.R. Chacko: None. C. Powell: None. B. Ndovu: None. E.Y. Ferreira: None. R. Rosenberg: None. J. Saini: None. S. Nevin: None. K. Yu: None. V. Fell: None. J.J. Larson: None. E. Atkinson: None. I. Bancos: Funding for investigator-…

Consensus-based disease definitions for endocrine immune-related adverse events of immune checkpoint inhibitors Open

Ling Zhu, Yee-Ming Melody Cheung, Cherie Chiang, Emily J. Gallagher, Ole‐Petter R. Hamnvik , et al. · 2025

Immune checkpoint inhibitors (ICIs) are an important class of cancer treatment. Endocrine immune-related adverse events (E-irAEs) account for a significant proportion of irAEs in ICI-treated patients. Diagnosing E-irAEs accurately and time…

OR18-04 Urine Steroid Metabolomics and Timed Urine Steroid Profiling: A Novel Test for the Diagnosis and Differential Diagnosis of Cushing’s Syndrome Open

Alessandro Prete, Lida Adbi, Joshua Bain, Fozia Shaheen, Onnicha Suntornlohanakul , et al. · 2025

Disclosure: A. Prete: HRA Pharmaceuticals, Lundbeck, Diurnal. L. Adbi: None. J.T. Bain: None. F. Shaheen: None. O. Suntornlohanakul: None. E. Deflorenne: None. A. Blanchard: None. M. Nestola: None. C. Pamporaki: None. I. Tizianel: None. E.…

SUN-475 Circadian Salivary Cortisol And Cortisone Concentrations In Patients With Endogenous Hypercortisolism: A Cross-sectional Study Open

Sarina Ahmadian, Shireen Renate Chacko, Shubhangi Sharma Sharma, Vanessa Fell, Anina Peersen , et al. · 2025

Disclosure: S. Ahmadian: None. S.R. Chacko: None. S. Sharma Sharma: None. V.M. Fell: None. A. Peersen: None. E.J. Atkinson: None. K.L. Moehnke: None. Y. Chai: None. S.K. Grebe: None. A.D. Maus: None. I. Bancos: None. Background: Cortisol s…

MON-011 Presentation, Management and Outcomes of Ectopic ACTH Syndrome: an International Multicenter Retrospective Study Open

Shireen R Chacko, Camila A Villavicencio Torres, Kai Yu, Steven G. Waguespack, Lin Lü , et al. · 2025

Disclosure: S.R. Chacko: None. C.A. Villavicencio Torres: None. K. Yu: None. S.G. Waguespack: None. L. Lu: None. Z. Belaya: None. T. Bandgar: None. A. Sada: None. O. Ragnarsson: None. B. Altieri: None. A. Newman: None. P. Vibhatavata: None…

SUN-474 Time-Point Intra-Individual Variability in Salivary Cortisol and Cortisone: A Cross-Sectional Study Open

Sarina Ahmadian, Camila A Villavicencio Torres, Vanessa Fell, Kayla Moehnke, Yubo Chai , et al. · 2025

Disclosure: S. Ahmadian: None. C.A. Villavicencio Torres: None. V.M. Fell: None. K.L. Moehnke: None. Y. Chai: None. R.L. Taylor: None. S.K. Grebe: None. A.D. Maus: None. I. Bancos: None. Background: Salivary cortisol (SalF), and cortisone …

SUN-061 Recovery of Adrenal Insufficiency After Surgical Remission of Endogenous Hypercortisolism: A Prospective Cohort Study Open

Shireen R Chacko, Jasmine Saini, Shubhangi Sharma Sharma, Sarina Ahmadian, Sara J. Achenbach , et al. · 2025

Disclosure: S.R. Chacko: None. J. Saini: None. S. Sharma Sharma: None. S. Ahmadian: None. S.J. Achenbach: None. E. Atkinson: None. V. Fell: None. J.J. Van Gompel: None. W.F. Young, Jr.: None. I. Bancos: None. Context: Evidence on the durat…

SUN-478 Assessment Of Cortisol And Dexamethasone Concentrations In Capillary Blood Open

Camila A Villavicencio Torres, Sarina Ahmadian, Kayla Moehnke, Vanessa Fell, Robert L. Taylor , et al. · 2025

Disclosure: C.A. Villavicencio Torres: None. S. Ahmadian: None. K. Moehnke: None. V.M. Fell: None. R.L. Taylor: None. S.K. Grebe: None. A.D. Maus: None. I. Bancos: None. Background: Evaluation of adrenal disorders relies on total cortisol …

SUN-054 Long-Term, Real-World, Safety and Effectiveness of Osilodrostat In Patients With Pituitary and Non-Pituitary Cushing’s Syndrome: 2-Year Interim Data From LINC 6 Open

Irina Bancos, Frédéric Castinetti, Eliza B. Geer, Stéphanie Espiard, C. Mouly , et al. · 2025

Disclosure: I. Bancos: Adrenas, consulting, advisory board, or data safety monitoring board fees (paid to institution outside this work), AstraZeneca, consulting, advisory board, or data safety monitoring board fees (paid to institution ou…

SUN-016 Determinants Of Quality Of Life In Patients With Immune-checkpoint-inhibitor Induced Adrenal Insufficiency Open

Justine Herndon, Yana Hleibiehova, Anamaria Bancos, Sara J. Achenbach, Elizabeth G. Atkinson , et al. · 2025

Disclosure: J. Herndon: None. Y. Hleibiehova: None. A. Bancos: None. S. Achenbach: None. E. Atkinson: None. D. Donegan: Camarus, Recordati. I. Bancos: None. Introduction: Studies show that quality of life (QOL) among patients with adrenal …

SUN-477 Cross-Sectional Comparison Study of Saliva Cortisone and Saliva Cortisol Versus Current Standard-Of-Care Venipuncture-Based Cortisol Measurements Open

Camila A Villavicencio Torres, Sarina Ahmadian, Vanessa Fell, Kayla Moehnke, Yubo Chai , et al. · 2025

Disclosure: C.A. Villavicencio Torres: None. S. Ahmadian: None. V.M. Fell: None. K. Moehnke: None. Y. Chai: None. R.L. Taylor: None. S.K. Grebe: None. A.D. Maus: None. I. Bancos: None. Background: Current standard-of-care assessment of adr…

SUN-456 Impact of Meditation Device Use on Quality of Life Following Surgery For Hypercortisolism Open

Jasmine Saini, Elio Ferreira Taveras, Yana Hleibiehova, Bahar Bahrani Fard, Malavika Suresh , et al. · 2025

Disclosure: J. Saini: None. E. Ferreira Taveras: None. Y. Hleibiehova: None. B. Bahrani Fard: None. M. Suresh: None. R. Sandooja: None. B. Salama: None. V. Fell: None. S. Achenbach: None. E.J. Atkinson: None. I. Bancos: None. Context: Pati…

SUN-405 Crinecerfont Shows Favorable Trends in Improving Weight-Related Outcomes in Adults With Classic Congenital Adrenal Hyperplasia: 1-Year Results From the CAHtalyst™ Adult Study Open

Irina Bancos, Henrik Falhammar, Philippe Chanson, Rosario Pivonello, Gianni Russo , et al. · 2025

Disclosure: I. Bancos: None. H. Falhammar: None. J. Young: None. R. Pivonello: Received research funding from Corcept Therapeutics, Neurocrine Biosciences, Recordati AG, Spruce Bioscience and Xeris Pharmaceuticals (Strongbridge Biopharma),…

MON-300 Cognitive Assessment in Patients With Primary Aldosteronism Versus Patients With Mild Autonomous Cortisol Secretion Open

Kai Yu, Jasmine Saini, Elizabeth J. Atkinson, Sara J. Achenbach, Vanessa Fell , et al. · 2025

Disclosure: K. Yu: None. J. Saini: None. E.J. Atkinson: None. S.J. Achenbach: None. V. Fell: None. I. Bancos: None. Background: Data on cognition in patients with primary aldosteronism (PA) are scarce. Mild autonomous cortisol secretion (M…

SUN-097 CAM2029 Octreotide Subcutaneous Depot Maintains Control of IGF-I and Symptoms of Acromegaly Across the 4-Week Dosing Interval and During Intervals Greater Than 28 Days: Data from the ACROINNOVA 1 Trial Open

Mônica R. Gadelha, Beverly M. K. Biller, Maria Fleseriu, Joanna L. Spencer-Segal, Julie Silverstein , et al. · 2025

Disclosure: Background: Acromegaly is characterized by excess growth hormone and insulin-like growth factor-I (IGF-I). Medical therapies aim to achieve biochemical and symptom control. However, some patients report the emergence of symptom…

SAT-468 Factors Associated With a Future Diagnosis of Adrenal Adenoma: a Case-Control Population Study Open

Ashley J Han, Sara J. Achenbach, Beth Atkinson, Irina Bancos · 2025

Disclosure: A.J. Han: None. S.J. Achenbach: None. B.J. Atkinson: None. I. Bancos: None. Background: The prevalence of adrenal adenomas continues to rise with increased utilization of imaging. However, much remains unknown about what risk f…

Glutamine antagonism suppresses tumor growth in adrenocortical carcinoma through inhibition of de novo nucleotide biosynthesis Open

Vasileios Chortis, Kleiton Silva-Borges, Cong-Hui Yao, Claudio Henrique T. Ribeiro, Luís Fernando Peinado Nagano , et al. · 2025

Dysregulation of cellular metabolism is a hallmark of cancer, which remains poorly understood in adrenocortical carcinoma (ACC). Here, we dissected ACC metabolism by integrating transcriptional profiling from human and mouse ACC, targeted …

Cortisol Testing to Diagnose Adrenal Insufficiency Following Adrenalectomy for Mild Autonomous Cortisol Secretion Open

Oksana Hamidi, Bahaa Salama, Tracy Wang, James W. Findling, Catherine D Zhang , et al. · 2025

Context Patients with mild autonomous cortisol secretion (MACS) can develop adrenal insufficiency after unilateral adrenalectomy. Objective This work aimed to determine the prevalence, duration, and predictors of adrenal insufficiency, and…

Impact of meditation device use on quality of life of patients following surgery for hypercortisolism Open

Jasmine Saini, Elio Ferreira Taveras, Yana Hleibiehova, Bahar Bahrani Fard, Malavika Suresh , et al. · 2025

Context Patients with endogenous hypercortisolism experience glucocorticoid withdrawal syndrome (GWS) post-surgery. Meditation may be an effective intervention to alleviate the severity of GWS. Objective To determine the acceptability of p…

OC31 - Prognostic value of serum inflammation-based scores in localized adrenocortical carcinoma undergoing adjuvant mitotane therapy: a multicenter ENSAT study Open

Giacomo Cristofolini, Mario Detomas, Soraya Puglisi, Roberto Novizio, Letizia Canu , et al. · 2025

Background Mitotane monotherapy is the standard adjuvant treatment for adrenocortical carcinoma (ACC), yet reliable predictors of treatment response remain lacking. Given the well-recognized interplay between inflammation and cancer progre…

A Community-Engaged Approach for Assessment of Cortisol Dynamic Range and Multilevel Chronic Stress in African Americans: FAITH! Heart Health+ Ancillary Study Open

Robin Ortiz, Joshua J. Joseph, Matthew P. Johnson, Lainey Moen, Mathias Lalika , et al. · 2025

Background Chronic stress in African American individuals is multilayered amid the context of experiences of racism and discrimination. Cortisol dynamic range (CDR) may be an indicator of chronic stress, but CDR is understudied in African …

Mentorship in endocrinology training: a cross-sectional study of the United States and Europe Open

David Toro-Tobón, Heather J. Billings, Anina Peersen, Elizabeth J. Atkinson, Antoan Stefan Šojat , et al. · 2025

A Systematic Review Supporting the Endocrine Society Clinical Practice Guideline on Management of Primary Aldosteronism Open

Magdoleen H. Farah, Moustafa Hegazi, Mohammed Firwana, Mohamed Abusalih, Samer Saadi , et al. · 2025

Context Primary aldosteronism (PA) is a leading endocrine cause of secondary hypertension. Objective To support the development of the Endocrine Society Clinical Practice Guideline on managing PA. Data Source MEDLINE, Embase, Scopus, and o…

Dehydroepiandrosterone Sulfate in Diagnosing Mild Autonomous Cortisol Secretion and Adrenal Insufficiency Open

Jasmine Saini, Bahaa Salama, Kai Yu, Shireen R Chacko, Ashley J Han , et al. · 2025

Context Data on diagnostic accuracy of dehydroepiandrosterone sulfate (DHEA-S) for mild autonomous cortisol secretion (MACS) and adrenal insufficiency (AI) are discrepant. Objective We conducted a systematic review and meta-analysis of pub…

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