Irina K. Golubovskaya
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View article: Efficacy of iptacopan monotherapy for suboptimal response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria
Efficacy of iptacopan monotherapy for suboptimal response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria Open
Aim. To evaluate the hematological response within 4 weeks of iptacopan monotherapy in patients with paroxysmal nocturnal hemoglobinuria and suboptimal response to long-term eculizumab therapy. Materials and methods. The analysis included …
View article: Basic Molecular Biology, Metabolic and Immunological Mechanisms of Fecal Microbiota Transplantation
Basic Molecular Biology, Metabolic and Immunological Mechanisms of Fecal Microbiota Transplantation Open
Aim: demonstration of basic molecular biological, metabolic and immunological effects of fecal microbiota transplantation (FMT), on the example of a rare case of acute graft-versus-host disease (GVHD) with intestinal damage in a patient af…
View article: Daratumumab in post-transplantation pure red cell aplasia in adults
Daratumumab in post-transplantation pure red cell aplasia in adults Open
Post-transplant pure red cell aplasia (PRCA) is a rare complication that occurs after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with ABO incompatibility.In most cases, this condition resolves without any treatment.Howe…
View article: Incidence, risk factors and clinical characteristics of bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation
Incidence, risk factors and clinical characteristics of bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation Open
Bronchiolitis obliterans (BO) is a severe form of chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Aim. The aim of current study was to evaluate the incidence, risk factors, an…
View article: Successful treatment of extramedullary relapsed/refractory B-acute lymphoblastic leukemia with Inotuzumab ozogamicin before and after allogeneic stem cell transplantation
Successful treatment of extramedullary relapsed/refractory B-acute lymphoblastic leukemia with Inotuzumab ozogamicin before and after allogeneic stem cell transplantation Open
Recent advances in treatment of relapsed/refractory B-Acute Lymphoblastic Leukemia (R/R B-ALL) are associated with targeted immune therapies, such as Blinatumomab, Inotuzumab ozogamicin and CAR-T cells.Several clinical studies demonstrate …
View article: Severe "Poor Graft Function" after Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients: Incidence, Risk Factors, and Outcomes
Severe "Poor Graft Function" after Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients: Incidence, Risk Factors, and Outcomes Open
Aim. Using strict criteria, to assess incidence, pretransplant risk factors, and outcomes of severe "poor graft function" (sPGF), following allogeneic hematopoietic stem cell transplantation (allo-HSCT) in adults. Materials & Methods. The …
View article: Paroxysmal nocturnal hemoglobinuria in children and adults: comparative clinical profile and long-term prognosis
Paroxysmal nocturnal hemoglobinuria in children and adults: comparative clinical profile and long-term prognosis Open
View article: Myelodysplastic syndrome/acute myeloid leukemia evolving from aplastic anemia: Efficacy of hematopoietic stem cell transplantation
Myelodysplastic syndrome/acute myeloid leukemia evolving from aplastic anemia: Efficacy of hematopoietic stem cell transplantation Open
Aplastic anemia (АА) is the most common clinical form of bone marrow failure which is still considered as a non-malignant disorder.However, development secondary myelodysplastic syndrome and acute myeloid leukemia (MDS/AML) in long-term AA…