Irina Miralda
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View article: Siglec-9 modulates mast cell function in homeostasis and in mouse models of allergic disease 4222
Siglec-9 modulates mast cell function in homeostasis and in mouse models of allergic disease 4222 Open
Description Mast cell activation is essential in allergic disease development. Engaging Sialic acid-binding immunoglobin-like lectins (Siglecs) such as CD33, Siglec-6, -7 and -8 has been shown to inhibit mast cell activation. We have ident…
View article: Proteomics profiling of inflammatory responses to elexacaftor/tezacaftor/ivacaftor in cystic fibrosis
Proteomics profiling of inflammatory responses to elexacaftor/tezacaftor/ivacaftor in cystic fibrosis Open
Background CFTR modulator therapies have positive clinical outcomes, yet chronic inflammation and bacterial infections persist in people with CF (pwCF). How elexacaftor–tezacaftor–ivacaftor (ETI) fails to improve innate immune signaling re…
View article: Siglec-9 is an inhibitory receptor on human mast cells in vitro
Siglec-9 is an inhibitory receptor on human mast cells in vitro Open
View article: Mast cell–derived factor XIIIA contributes to sexual dimorphic defense against group B streptococcal infections
Mast cell–derived factor XIIIA contributes to sexual dimorphic defense against group B streptococcal infections Open
Invasive bacterial infections remain a major cause of human morbidity. Group B streptococcus (GBS) are Gram-positive bacteria that cause invasive infections in humans. Here, we show that factor XIIIA-deficient (FXIIIA-deficient) female mic…
View article: The emerging oral pathogen, <i>Filifactor alocis</i>, extends the functional lifespan of human neutrophils
The emerging oral pathogen, <i>Filifactor alocis</i>, extends the functional lifespan of human neutrophils Open
Periodontitis is a chronic inflammatory infectious disease that affects the integrity of tooth‐supporting tissues and has adverse systemic consequences. Advances in sequencing technologies have uncovered organisms that are exclusively foun…
View article: Mast cell surfaceome characterization reveals CD98 heavy chain is critical for optimal cell function
Mast cell surfaceome characterization reveals CD98 heavy chain is critical for optimal cell function Open
View article: Periodontal Pathogens’ strategies disarm neutrophils to promote dysregulated inflammation
Periodontal Pathogens’ strategies disarm neutrophils to promote dysregulated inflammation Open
Periodontitis is an irreversible, chronic inflammatory disease where inflammophilic pathogenic microbial communities accumulate in the gingival crevice. Neutrophils are a major component of the innate host response against bacterial challe…
View article: Whole Transcriptome Analysis Reveals That Filifactor alocis Modulates TNFα-Stimulated MAPK Activation in Human Neutrophils
Whole Transcriptome Analysis Reveals That Filifactor alocis Modulates TNFα-Stimulated MAPK Activation in Human Neutrophils Open
Periodontitis is an irreversible, bacteria-induced, chronic inflammatory disease that compromises the integrity of tooth-supporting tissues and adversely affects systemic health. As the immune system's first line of defense against bacteri…
View article: Human Neutrophil Granule Exocytosis in Response to Mycobacterium smegmatis
Human Neutrophil Granule Exocytosis in Response to Mycobacterium smegmatis Open
Mycobacterium smegmatis rarely causes disease in the immunocompetent, but reported cases of soft tissue infection describe abscess formation requiring surgical debridement for resolution. Neutrophils are the first innate immune cells to ac…
View article: Putative Periodontal Pathogens, Filifactor alocis and Peptoanaerobacter stomatis, Induce Differential Cytokine and Chemokine Production by Human Neutrophils
Putative Periodontal Pathogens, Filifactor alocis and Peptoanaerobacter stomatis, Induce Differential Cytokine and Chemokine Production by Human Neutrophils Open
Periodontitis is a highly prevalent infectious disease that affects ~ 50% of the adults in the USA alone. Two Gram-positive anaerobic oral bacteria, Filifactor alocis and Peptoanaerobacter stomatis, have emerged as important periodontal pa…
View article: TFAM overexpression reduces pathological cardiac remodeling
TFAM overexpression reduces pathological cardiac remodeling Open
View article: NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages
NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages Open
Key Points Efferocytosis of ACs by inflammatory macrophages activates NADPH oxidase in a CD11b-TLR2/4-MyD88–dependent manner. ROS generated positively regulate acidification and proteolysis in efferosomes, and limit cross-presentation of A…
View article: Re-Examining Neutrophil Participation in GN
Re-Examining Neutrophil Participation in GN Open
Significant advances in understanding the pathogenesis of GN have occurred in recent decades. Among those advances is the finding that both innate and adaptive immune cells contribute to the development of GN. Neutrophils were recognized a…
View article: Multiple Phenotypic Changes Define Neutrophil Priming
Multiple Phenotypic Changes Define Neutrophil Priming Open
Exposure to pro-inflammatory cytokines, chemokines, mitochondrial contents, and bacterial and viral products induces neutrophils to transition from a basal state into a primed one, which is currently defined as an enhanced response to acti…
View article: Filifactor alocis Promotes Neutrophil Degranulation and Chemotactic Activity
Filifactor alocis Promotes Neutrophil Degranulation and Chemotactic Activity Open
Filifactor alocis is a recently recognized periodontal pathogen; however, little is known regarding its interactions with the immune system. As the first-responder phagocytic cells, neutrophils are recruited in large numbers to the periodo…