Iris Baars
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View article: Investigating pyroptosis as a mechanism of <i>L. major</i> cell‐to‐cell spread in the human <scp>BLaER1</scp> infection model
Investigating pyroptosis as a mechanism of <i>L. major</i> cell‐to‐cell spread in the human <span>BLaER1</span> infection model Open
Leishmania is the causative agent of the tropical neglected disease leishmaniasis and infects macrophages as its definitive host cell. In order to sustain and propagate infections, Leishmania parasites have to complete cycles of exit and r…
View article: Leishmania major drives host phagocyte death and cell-to-cell transfer depending on intracellular pathogen proliferation rate
Leishmania major drives host phagocyte death and cell-to-cell transfer depending on intracellular pathogen proliferation rate Open
The virulence of intracellular pathogens relies largely on the ability to survive and replicate within phagocytes but also on release and transfer into new host cells. Such cell-to-cell transfer could represent a target for counteracting m…
View article: Using BLaER1 as model for L. major infection of human macrophages to investigate the role of pyroptosis in parasite spreading
Using BLaER1 as model for L. major infection of human macrophages to investigate the role of pyroptosis in parasite spreading Open
Leishmania is the causative agent of the tropical neglected disease leishmaniasis and infects macrophages as its definitive host cell . In order to sustain and propagate infections, Leishmania parasites have to complete cycles of exit and …
View article: CD11c-expressing Ly6C+CCR2+ monocytes constitute a reservoir for efficient Leishmania proliferation and cell-to-cell transmission
CD11c-expressing Ly6C+CCR2+ monocytes constitute a reservoir for efficient Leishmania proliferation and cell-to-cell transmission Open
The virulence of intracellular pathogens such as Leishmania major (L. major) relies largely on their ability to undergo cycles of replication within phagocytes, release, and uptake into new host cells. While all these steps are critical fo…