Iris Kruijff
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View article: The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases Open
Lipid alterations in the brain have been implicated in many neurodegenerative diseases. To facilitate comparative lipidomic research across brain diseases, we establish a data common named the Neurolipid Atlas that we prepopulated with iso…
View article: The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4 Open
Lipid changes in the brain have been implicated in many neurodegenerative diseases including Alzheimer’s Disease (AD), Parkinson’s disease and Amyotrophic Lateral Sclerosis. To facilitate comparative lipidomic research across brain-disease…
View article: Pridopidine subtly ameliorates motor skills in a mouse model for vanishing white matter
Pridopidine subtly ameliorates motor skills in a mouse model for vanishing white matter Open
The leukodystrophy vanishing white matter (VWM) is characterized by chronic and episodic acute neurological deterioration. Curative treatment is presently unavailable. Pathogenic variants in the genes encoding eukaryotic initiation factor …
View article: Distinct pools of cholesterol regulate APP maturation and Aβ42/40 ratio
Distinct pools of cholesterol regulate APP maturation and Aβ42/40 ratio Open
Background Changes in amyloid precursor protein (APP) processing towards an increased Aβ42/40 ratio is a major hallmark of Alzheimer’s disease (AD). For sporadic AD, it is unknown what drives this increase, but cholesterol has been shown t…