Iris Helfrich
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View article: Serpins A1/A3 within tumor-derived extracellular vesicles support pro-tumoral bias of neutrophils in cancer
Serpins A1/A3 within tumor-derived extracellular vesicles support pro-tumoral bias of neutrophils in cancer Open
Neutrophils are known to play an important regulatory role during tumor progression in several types of cancer. However, the mechanisms responsible for their tumorigenic bias and extended lifespan in cancer are not clear to date. This stud…
View article: RECQL4 affects MHC class II‐mediated signalling and favours an immune‐evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma
RECQL4 affects MHC class II‐mediated signalling and favours an immune‐evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma Open
Background Cancer immunotherapy has transformed metastatic cancer treatment, yet challenges persist regarding therapeutic efficacy. RECQL4, a RecQ‐like helicase, plays a central role in DNA replication and repair as part of the DNA damage …
View article: Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1
Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1 Open
PIF1 is a conserved helicase and G4 DNA binding and unwinding enzyme, with roles in genome stability. Human PIF1 (hPIF1) is poorly understood, but its functions can become critical for tumour cell survival during oncogene-driven replicatio…
View article: T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels
T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels Open
To improve immunotherapy for brain tumors, it is important to determine the principal intracranial site of T cell recruitment from the bloodstream and their intracranial route to brain tumors. Using intravital microscopy in mouse models of…
View article: Identification and characterization of tertiary lymphoid structures in brain metastases
Identification and characterization of tertiary lymphoid structures in brain metastases Open
Summary Brain metastases (BrM) are the most common cancers in the brain. We performed transcriptome-wide gene expression profiling combined with spatial immune cell profiling to characterize the tumor immune microenvironment in BrM from di…
View article: Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization
Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization Open
Supplementary Movie 5
View article: Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization
Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization Open
Supplementary Movie 3
View article: Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization
Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization Open
Supplementary Movie 4
View article: Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization
Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization Open
Supplementary Movie 3
View article: Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization
Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization Open
Supplementary Movie 1
View article: Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization
Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization Open
Supplementary Movie 1
View article: Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization
Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization Open
Supplementary Movie 4
View article: Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization
Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization Open
Supplementary Figures and Figure legends, Supplementary Video legends and supplementary materials and methods
View article: Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization
Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization Open
Supplementary Movie 6
View article: Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization
Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization Open
Supplementary Movie 6
View article: Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization
Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization Open
Supplementary Figures and Figure legends, Supplementary Video legends and supplementary materials and methods
View article: Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization
Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization Open
Supplementary Movie 2
View article: Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization
Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization Open
Supplementary Movie 2
View article: Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization
Supplementary Data from Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization Open
Supplementary Movie 5
View article: BMRK-09 PROGNOSTIC ROLE OF TUMOR-INFILTRATING LYMPHOCYTES AND TERTIARY LYMPHOID STRUCTURES IN BRAIN METASTASIS
BMRK-09 PROGNOSTIC ROLE OF TUMOR-INFILTRATING LYMPHOCYTES AND TERTIARY LYMPHOID STRUCTURES IN BRAIN METASTASIS Open
Brain metastases (BrMs) constitute the most common type of brain cancer with abysmal prognosis. Given the high incidence and poor prognosis of BrM, understanding the tumor microenvironment (TME) architecture across BrM subtypes is increasi…
View article: P12.11 RECQL4 promotes immune evasion and limits response to anti-PD-1 therapy and survival in melanoma patients
P12.11 RECQL4 promotes immune evasion and limits response to anti-PD-1 therapy and survival in melanoma patients Open
Background The DNA helicase RECQL4 is involved in DNA replication, recombination, transcription and damage repair by unwinding various DNA structures. Components of the DNA repair machinery have been shown to influence response to immune c…
View article: ComplexEye: a multi-lens array microscope for high-throughput embedded immune cell migration analysis
ComplexEye: a multi-lens array microscope for high-throughput embedded immune cell migration analysis Open
Autonomous migration is essential for the function of immune cells such as neutrophils and plays an important role in numerous diseases. The ability to routinely measure or target it would offer a wealth of clinical applications. Video mic…
View article: ComplexEye - a multi lens array microscope for High-Throughput embedded immune cell migration analysis
ComplexEye - a multi lens array microscope for High-Throughput embedded immune cell migration analysis Open
This dataset contains raw high-resolution movies of migrating neutrophils, which were recorded using the ComplexEye, an array microscope with 16 independent aberration-corrected glass lenses spaced at the pitch of a 96-well plate. Please s…
View article: ComplexEye - a multi lens array microscope for High-Throughput embedded immune cell migration analysis
ComplexEye - a multi lens array microscope for High-Throughput embedded immune cell migration analysis Open
This dataset contains raw high-resolution movies of migrating neutrophils, which were recorded using the ComplexEye, an array microscope with 16 independent aberration-corrected glass lenses spaced at the pitch of a 96-well plate. Please s…
View article: Author Correction: Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma
Author Correction: Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma Open
In the version of this article initially published, the description of the proteomic analysis was incorrectly termed reverse phase protein array (RPPA) instead of liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS).The Fig…
View article: Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma
Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma Open
Recent studies suggest that BRAF V600 -mutated melanomas in particular respond to dual anti-programmed cell death protein 1 (PD-1) and anti-cytotoxic T lymphocyte-associated protein 4 (CTLA-4) immune checkpoint inhibition (ICI). Here we id…
View article: ComplexEye - a multi lens array microscope for High-Throughput embedded immune cell migration analysis
ComplexEye - a multi lens array microscope for High-Throughput embedded immune cell migration analysis Open
This dataset contains raw high-resolution movies of migrating neutrophils, which were recorded using an array microscope with 16 independent aberration-corrected glass lenses spaced at the pitch of a 96-well plate.
View article: Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization
Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization Open
Supplementary Figures and Figure legends, Supplementary Video legends and supplementary materials and methods
View article: Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization
Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization Open
Supplementary Movie 2