Iris Piwonski
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A macrophage-predominant immunosuppressive microenvironment and therapeutic vulnerabilities in advanced salivary gland cancer Open
Salivary gland cancers are rare, diverse malignancies characterized by poor response to immunotherapy. The tumor immune environment in these cancers remains poorly understood. To address this, we perform an integrative analysis of the tumo…
View article: Characterizing uveal melanoma patients with peritoneal metastases: A retrospective single-center analysis
Characterizing uveal melanoma patients with peritoneal metastases: A retrospective single-center analysis Open
PM in mUM patients is rare and in contrast to other extra-abdominal tumors does not worsen prognosis. Prognosis is greatly influenced by the metastatic pattern, which is determined by tumor biology, as evidenced by its correlation with gen…
View article: Multiple Mutations—A Genetic Marker for Extracapsular Spread in Human Papillomavirus/p16‐Positive Oropharyngeal Carcinoma
Multiple Mutations—A Genetic Marker for Extracapsular Spread in Human Papillomavirus/p16‐Positive Oropharyngeal Carcinoma Open
Background In the 8th edition of the TNM classification, extracapsular spread (ECS) became a factor in classifying the UICC stage of oropharyngeal carcinomas (OPSCC). We aimed to find genetic markers for ECS and to identify differences bet…
Volumetric Reconstruction of Prostatectomy Specimens from Histology Open
Surgical treatment for prostate cancer often involves organ removal, i.e., prostatectomy. Pathology reports on these specimens convey treatment-relevant information. Beyond these reports, the diagnostic process generates extensive and comp…
View article: Feasibility analysis of using patient-derived tumour organoids for treatment decision guidance in locally advanced head and neck squamous cell carcinoma
Feasibility analysis of using patient-derived tumour organoids for treatment decision guidance in locally advanced head and neck squamous cell carcinoma Open
Our findings suggest that with high-quality samples and efficient tissue processing, PDO screens can be successfully performed in 77 % of HNSCC patients. Given the procedural challenges involved, future clinical trials aiming to the utilit…
View article: Integrative analysis reveals a macrophage-predominant, immunosuppressive immune microenvironment and subtype-specific therapeutic vulnerabilities in advanced salivary gland cancer
Integrative analysis reveals a macrophage-predominant, immunosuppressive immune microenvironment and subtype-specific therapeutic vulnerabilities in advanced salivary gland cancer Open
Background Salivary gland cancers (SGC) are rare and heterogeneous malignant tumors. Advanced SGC lack established treatment options and show poor response to immunotherapy. Here, an integrative multi-omics analysis in a large cohort of ad…
Resection status and margin control in intraoperative frozen sectioning analysis of oral squamous cell carcinoma Open
Purpose Intraoperative frozen section analysis (IFSA) is a well-established procedure for determining the intraoperative soft tissue resection status in patients with oral squamous cell carcinoma (OSCC). Margin status is a major predictor …
Subgroup Analysis of Overall Survival among Smoking and Non-Smoking Elderly Patients with HNSCC Open
Smoking is a leading cause of head and neck squamous cell carcinoma (HNSCC). However, non-smokers are also affected by HNSCC, and the prognostic factors applicable to older non-smokers with HNSCC are largely unknown. The aim of this study …
Prognostic value of regulatory T cells and T helper 17 cells in high grade serous ovarian carcinoma Open
Purpose In recent years the tumor microenvironment and its interaction with the tumor has emerged into research focus with increased attention to the composition of Tumor-infiltrating lymphocytes. We wanted to quantify the composition of R…
Influence of Tumor Site on Survival in Young Patients with Head and Neck Squamous Cell Carcinoma Open
The number of patients under the age of 45 diagnosed with head and neck squamous cell carcinomas (HNSCC) is increasing, probably due to the incidence of oropharyngeal cancers. Comparisons of HNSCC in young and old patients regarding tumor …
Predictors for Adherence to Treatment Strategies in Elderly HNSCC Patients Open
Finding a cure may be less important than ensuring the quality of life in elderly patients with head and neck squamous cell carcinoma (HNSCC). The aim of this study was to determine predictors for adherence. Clinical and pathological data …
Carcinoma of Unknown Primary and the 8th Edition <span>TNM</span> Classification for Head and Neck Cancer Open
Objective In the 8th Edition TNM Classification for Head and Neck Cancer, the classification for carcinoma of unknown primary (CUP) changed in addition to oropharyngeal carcinomas. The current classification considers extranodal extension …
Incidence and survival of HNSCC patients living with HIV compared with HIV-negative HNSCC patients Open
Purpose The aim was to analyze the incidence and survival of patients living with HIV (PLWH) with head and neck squamous cell carcinoma (HNSCC) and to compare with a control group of HIV-negative HNSCC patients. Methods Clinicopathological…
Impact of Smoking on the Survival of Patients With High-risk HPV-positive HNSCC: A Meta-analysis Open
Smoking is a negative prognostic factor for overall survival in patients with hr-HPV+ HNSCC and should thus be an important part of staging and treatment.
Surgical versus clinical staging prior to primary chemoradiation in patients with cervical cancer FIGO stages IIB–IVA: oncologic results of a prospective randomized international multicenter (Uterus-11) intergroup study Open
Our study did not show a difference in disease-free survival between surgical and clinical staging in patients with locally advanced cervical cancer. There was a significant benefit in disease-free survival for patients with FIGO stage IIB…
Carcinoma of unknown primary and the 8th Edition TNM Classification for Head and Neck Cancer Open
Introduction In the 8th Edition TNM Classification for Head and Neck Cancer, the classification for Carcinoma of unknown primary changed in addition to the oropharyngeal carcinomas. The aim of the study was to investigate the influence of …
A Novel Method for the Correlation of Histological Slides and MRI Imaging of the Prostate using 3D Vertex Models Open
Background: The evaluation and improvement of MRI-based grading schemes such as PI-RADS requires the correlation of histological findings with MRI images. Several approaches have been described to join the two modalities. However, these ap…