Iris Ribitsch
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Fetal Immunomodulatory Environment Following Cartilage Injury—The Key to CARTILAGE Regeneration? Open
Fetal cartilage fully regenerates following injury, while in adult mammals cartilage injury leads to osteoarthritis (OA). Thus, in this study, we compared the in vivo injury response of fetal and adult ovine articular cartilage histologica…
Species variations in tenocytes’ response to inflammation require careful selection of animal models for tendon research Open
For research on tendon injury, many different animal models are utilized; however, the extent to which these species simulate the clinical condition and disease pathophysiology has not yet been critically evaluated. Considering the importa…
Molecular Mechanisms of Fetal Tendon Regeneration Versus Adult Fibrous Repair Open
Tendinopathies are painful, disabling conditions that afflict 25% of the adult human population. Filling an unmet need for realistic large-animal models, we here present an ovine model of tendon injury for the comparative study of adult sc…
Species variations in tenocytes’ response to inflammation require careful selection of animal models for tendon research Open
For research on tendon injury, many different animal models are utilized; however, the extent to which these species simulate the clinical condition and disease pathophysiology has not yet been critically evaluated. Considering the importa…
Regenerative Medicine for Equine Musculoskeletal Diseases Open
Musculoskeletal injuries and chronic degenerative diseases commonly affect both athletic and sedentary horses and can entail the end of their athletic careers. The ensuing repair processes frequently do not yield fully functional regenerat…
View article: Large Animal Models in Regenerative Medicine and Tissue Engineering: To Do or Not to Do
Large Animal Models in Regenerative Medicine and Tissue Engineering: To Do or Not to Do Open
Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an increasing drive toward clinical translation of breakthrough technologies. However, the progression of promising preclinical data to achieve successful cli…
Age‐related changes of tendon fibril micro‐morphology and gene expression Open
Aging is hypothesized to be associated with changes in tendon matrix composition which may lead to alteration of tendon material properties and hence propensity to injury. Altered gene expression may offer insights into disease pathophysio…
A novel magnet-based scratch method for standardisation of wound-healing assays Open
A novel magnetic scratch method achieves repeatability, reproducibility and geometric control greater than pipette scratch assays and closely approximating the precision of cell exclusion assays while inducing the cell injury inherently ne…
Finite Element Modelling Simulated Meniscus Translocation and Deformation during Locomotion of the Equine Stifle Open
We developed a finite element model (FEM) of the equine stifle joint to identify pressure peaks and simulate translocation and deformation of the menisci. A series of sectional magnetic resonance images (1.5 T) of the stifle joint of a 23 …
Co-culture of osteochondral explants and synovial membrane as in vitro model for osteoarthritis Open
The purpose of the current study was to establish an in vitro model for osteoarthritis (OA) by co-culture of osteochondral and synovial membrane explants. Osteochondral explants were cultured alone (control-1) or in co-culture with synovia…
Fetal articular cartilage regeneration versus adult fibrocartilaginous repair: secretome proteomics unravels molecular mechanisms in an ovine model Open
Osteoarthritis (OA), a degenerative joint disease characterized by progressive cartilage degeneration, is one of the leading causes of disability worldwide owing to the limited regenerative capacity of adult articular cartilage. Currently,…
Structure—Function relationships of equine menisci Open
Meniscal pathologies are among the most common injuries of the femorotibial joint in both human and equine patients. Pathological forces and ensuing injuries of the cranial horn of the equine medial meniscus are considered analogous to tho…
Evaluation of transport conditions for autologous bone marrow-derived mesenchymal stromal cells for therapeutic application in horses Open
Background. Mesenchymal stromal cells (MSCs) are increasingly used for clinical applications in equine patients. For MSC isolation and expansion, a laboratory step is mandatory, after which the cells are sent back to the attending veterina…