Iris Schulz
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View article: Evaluative sub-source and activity level reporting in Austria, Germany and Switzerland
Evaluative sub-source and activity level reporting in Austria, Germany and Switzerland Open
An increasing number of scientific studies in the field of forensic genetics suggest that questions arising in courtrooms have shifted in recent years from "Whose DNA is it?" to "How did that person's DNA get there?", or, expressed in the …
View article: Evaluating novel and conventional cell‐separation techniques for sexual assault investigations
Evaluating novel and conventional cell‐separation techniques for sexual assault investigations Open
Biological evidence from sexual assaults frequently includes few male cells (i.e., spermatozoa) and numerous female cells (i.e., epithelial cells). In practice, their genetic analysis typically involves separating the victim's cells from t…
View article: Application of the Agilent 2100 Bioanalyzer instrument as quality control for next‐generation sequencing
Application of the Agilent 2100 Bioanalyzer instrument as quality control for next‐generation sequencing Open
Next‐generation sequencing (NGS) technologies have expanded the spectrum of forensic DNA analysis by facilitating efficient and precise genotyping of a large number of genetic markers. Yet, challenges persist regarding complex sample proce…
View article: Exploring the potential of genetic analysis in historical blood spots for patients with iodine-deficient goiter and thyroid carcinomas in Switzerland and Germany (1929–1989)
Exploring the potential of genetic analysis in historical blood spots for patients with iodine-deficient goiter and thyroid carcinomas in Switzerland and Germany (1929–1989) Open
View article: Zygotic-splitting after in vitro fertilization and prenatal parenthood testing after suspected embryo mix-up – a case report
Zygotic-splitting after in vitro fertilization and prenatal parenthood testing after suspected embryo mix-up – a case report Open
After in vitro fertilization with a single embryo, the parents learned about being pregnant with twins in the 10th week with various indications that an embryonic mix-up could have taken place. The affected couple thus expressed the urgent…
View article: Targeted recovery of male cells in a male and female same‐cell mixture
Targeted recovery of male cells in a male and female same‐cell mixture Open
DNA mixture deconvolution in the forensic DNA community has been addressed in a variety of ways. “Front‐end” methods that separate the cellular components of mixtures can provide a significant benefit over computational methods as there is…
View article: DEPArray™ single-cell technology: A validation study for forensic applications
DEPArray™ single-cell technology: A validation study for forensic applications Open
In forensics investigations, it is common to encounter biological mixtures consisting of homogeneous or heterogeneous components from multiple individuals and with different genetic contributions. One promising mixture deconvolution strate…
View article: Hyperphosphatemia With Normal Kidney Function Associated With Genetic Variants of GALNT3
Hyperphosphatemia With Normal Kidney Function Associated With Genetic Variants of GALNT3 Open
View article: A systematic approach to improve downstream single‐cell analysis for the DEPArray<scp>™</scp> technology
A systematic approach to improve downstream single‐cell analysis for the DEPArray<span>™</span> technology Open
Most commercially available STR amplification kits have never been fully validated for low template DNA analysis, highlighting the need for testing different PCR kits and conditions for improving single‐cell profiling. Here, current strate…
View article: Collecting touch <scp>DNA</scp> from glass surfaces using different sampling solutions and volumes: Immediate and storage effects on genetic <scp>STR</scp> analysis
Collecting touch <span>DNA</span> from glass surfaces using different sampling solutions and volumes: Immediate and storage effects on genetic <span>STR</span> analysis Open
Touch DNA has become increasingly important evidence in todays' forensic casework. However, due to its invisible nature and typically minute amounts of DNA, the collection of biological material from touched objects remains a particular ch…
View article: The DNA‐Buster: The evaluation of an alternative DNA recovery approach
The DNA‐Buster: The evaluation of an alternative DNA recovery approach Open
Touch DNA recovery techniques can have limitations, as their effectiveness depends on the substrate on which the DNA of a person of interest can be found. In this study, an in-house dry-vacuuming device, the DNA-Buster, was compared to tra…
View article: Recommendations for the successful identification of altered human remains using standard and emerging technologies: Results of a systematic approach
Recommendations for the successful identification of altered human remains using standard and emerging technologies: Results of a systematic approach Open
Successful DNA-based identification of altered human remains relies on the condition of the corpses and varies between tissue types. Therefore, the aim of this prospective multicenter study was to generate evidence-based recommendations fo…
View article: Technical note: Comparison of forensic swabs for intravaginal sampling
Technical note: Comparison of forensic swabs for intravaginal sampling Open
This study compared the currently used swab Prionics ForensiX Evidence Collection Kit with the alternatives Prionics ForensiX Evidence Collection Tube SafeDry and Sarstedt Forensic Swab XL. Volunteers provided intravaginal swabs collected …
View article: Validation and beyond: Next generation sequencing of forensic casework samples including challenging tissue samples from altered human corpses using the <scp>MiSeq FGx</scp> system
Validation and beyond: Next generation sequencing of forensic casework samples including challenging tissue samples from altered human corpses using the <span>MiSeq FGx</span> system Open
The proceeding developments in next generation sequencing (NGS) technologies enable increasing discrimination power for short tandem repeat (STR) analyses and provide new possibilities for human identification. Therefore, the growing relev…
View article: Which tissue to take? A retrospective study of the identification success of altered human remains
Which tissue to take? A retrospective study of the identification success of altered human remains Open
In forensic medicine, deceased are usually identified by comparing ante- and post-mortem dental or radiological features. However, in severe putrefaction, burning or absent reference data, the remaining tool for identifying human remains i…
View article: Identification and characterization of novel rapidly mutating Y‐chromosomal short tandem repeat markers
Identification and characterization of novel rapidly mutating Y‐chromosomal short tandem repeat markers Open
Short tandem repeat polymorphisms on the male‐specific part of the human Y‐chromosome (Y‐STRs) are valuable tools in many areas of human genetics. Although their paternal inheritance and moderate mutation rate (~10 −3 mutations per marker …