Iris Shai
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View article: Serum Galectin-9 and Decorin in relation to brain aging and the green-Mediterranean diet: A secondary analysis of the DIRECT PLUS randomized trial
Serum Galectin-9 and Decorin in relation to brain aging and the green-Mediterranean diet: A secondary analysis of the DIRECT PLUS randomized trial Open
NCT03020186.
View article: Individual response to lifestyle interventions: a pooled analysis of three long-term weight loss trials
Individual response to lifestyle interventions: a pooled analysis of three long-term weight loss trials Open
Aims We explored the manifestations of individual weight loss (WL) response to long-term lifestyle interventions on cardiometabolic risk. Methods and results We pooled data from three large long-term lifestyle WL-intervention trials: 24-mo…
View article: Gal-9 and DCN Serum Expression Reflect Accelerated Brain Aging and Are Attenuated by the Green-Mediterranean Diet: The 18-month DIRECT PLUS Proteomics-Brain MRI Trial
Gal-9 and DCN Serum Expression Reflect Accelerated Brain Aging and Are Attenuated by the Green-Mediterranean Diet: The 18-month DIRECT PLUS Proteomics-Brain MRI Trial Open
Background We recently reported that a green-Mediterranean (green-MED), high-polyphenol diet is potentially neuroprotective for age-related brain atrophy. Here, we explored the interplay between dietary intervention, proteomics profile, an…
View article: Gut microbial metabolism of bile acids modifies the effect of Mediterranean diet interventions on cardiometabolic risk in a randomized controlled trial
Gut microbial metabolism of bile acids modifies the effect of Mediterranean diet interventions on cardiometabolic risk in a randomized controlled trial Open
Bile acids (BAs) undergo extensive microbial metabolism in the gut and exert hormone-like functions on physiological processes underlying metabolic risk. However, the extent to which gut BA profiles predict cardiometabolic risk and explain…
View article: Glycemic control contributes to the neuroprotective effects of Mediterranean and green-Mediterranean diets on brain age: the DIRECT PLUS brain-magnetic resonance imaging randomized controlled trial
Glycemic control contributes to the neuroprotective effects of Mediterranean and green-Mediterranean diets on brain age: the DIRECT PLUS brain-magnetic resonance imaging randomized controlled trial Open
Glycemic control contributes to the neuroprotective effects of the MED and green-MED diets on brain age. Polyphenols-rich diet components as Mankai and green tea may contribute to a more youthful brain age. This trial was registered at cli…
View article: The effect of Mankai plant consumption on postprandial glycaemic response among patients with type 2 diabetes: A randomized crossover trial
The effect of Mankai plant consumption on postprandial glycaemic response among patients with type 2 diabetes: A randomized crossover trial Open
Aim To explore the effect of Mankai, a cultivated aquatic duckweed green plant, on postprandial glucose (PG) excursions in type 2 diabetes (T2D). Methods In a 4‐week, randomized crossover‐controlled trial, we enrolled 45 adults with T2D (H…
View article: Altered proteome profiles related to visceral adiposity may mediate the favorable effect of <scp>green Mediterranean</scp> diet: the <scp>DIRECT‐PLUS</scp> trial
Altered proteome profiles related to visceral adiposity may mediate the favorable effect of <span>green Mediterranean</span> diet: the <span>DIRECT‐PLUS</span> trial Open
Objective The objective of this study was to explore the effects of a green Mediterranean (green‐MED) diet, which is high in dietary polyphenols and green plant‐based protein and low in red/processed meat, on cardiovascular disease and inf…
View article: Visceral adipose tissue area and proportion provide distinct reflections of cardiometabolic outcomes in weight loss; Pooled analysis of MRI-assessed CENTRAL and DIRECT PLUS dietary randomized controlled trials
Visceral adipose tissue area and proportion provide distinct reflections of cardiometabolic outcomes in weight loss; Pooled analysis of MRI-assessed CENTRAL and DIRECT PLUS dietary randomized controlled trials Open
Background Visceral adipose tissue (VAT) is well established as a pathogenic fat depot, while superficial subcutaneous adipose tissue (SAT) is associated with an improved or no association with the cardiovascular state. However, it is uncl…
View article: Novel proteomic signatures may indicate MRI-assessed intrahepatic fat state and changes: The DIRECT PLUS clinical trial
Novel proteomic signatures may indicate MRI-assessed intrahepatic fat state and changes: The DIRECT PLUS clinical trial Open
Background and Aims: We demonstrated in the randomized 18-month DIRECT PLUS trial (n = 294) that a Mediterranean (MED) diet, supplemented with polyphenol-rich Mankai duckweed, green tea, and walnuts and restricted in red/processed meat, ca…
View article: Deep learning‐based BMI inference from structural brain MRI reflects brain alterations following lifestyle intervention
Deep learning‐based BMI inference from structural brain MRI reflects brain alterations following lifestyle intervention Open
Obesity is associated with negative effects on the brain. We exploit Artificial Intelligence (AI) tools to explore whether differences in clinical measurements following lifestyle interventions in overweight population could be reflected i…
View article: Sex modifies the associations of regional fat with cognitive functioning and AD‐related brain volumes, in Israeli middle‐aged adults at high AD risk
Sex modifies the associations of regional fat with cognitive functioning and AD‐related brain volumes, in Israeli middle‐aged adults at high AD risk Open
Background High body mass index (BMI) has been consistently linked to poorer cognition and higher dementia risk, with different associations in males and females. However, BMI does not represent well specific fat depots. We examined in mid…
View article: Long-term green-Mediterranean diet may favor fasting morning cortisol stress hormone; the DIRECT-PLUS clinical trial
Long-term green-Mediterranean diet may favor fasting morning cortisol stress hormone; the DIRECT-PLUS clinical trial Open
Background Fasting morning cortisol (FMC) stress hormone levels, are suggested to reflect increased cardiometabolic risk. Acute response to weight loss diet could elevate FMC. Richer Polyphenols and lower carbohydrates diets could favor FM…
View article: Successful weight regain attenuation by autologous fecal microbiota transplantation is associated with non-core gut microbiota changes during weight loss; randomized controlled trial
Successful weight regain attenuation by autologous fecal microbiota transplantation is associated with non-core gut microbiota changes during weight loss; randomized controlled trial Open
We previously reported that autologous-fecal-microbiota-transplantation (aFMT), following 6 m of lifestyle intervention, attenuated subsequent weight regain and insulin rebound for participants consuming a high-polyphenol green-Mediterrane…
View article: The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial
The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial Open
Background Epigenetic age is an estimator of biological age based on DNA methylation; its discrepancy from chronologic age warrants further investigation. We recently reported that greater polyphenol intake benefitted ectopic fats, brain f…
View article: A polyphenol-rich green Mediterranean diet enhances epigenetic regulatory potential: the DIRECT PLUS randomized controlled trial
A polyphenol-rich green Mediterranean diet enhances epigenetic regulatory potential: the DIRECT PLUS randomized controlled trial Open
The green-MED high polyphenol diet, rich in green tea and Mankai, renders a high capacity to regulate an individual's epigenome. Our findings suggest epigenetic key drivers such as folate and green diet marker to mediate this capacity and …
View article: The effect of weight loss following 18 months of lifestyle intervention on brain age assessed with resting-state functional connectivity
The effect of weight loss following 18 months of lifestyle intervention on brain age assessed with resting-state functional connectivity Open
Background: Obesity negatively impacts multiple bodily systems, including the central nervous system. Retrospective studies that estimated chronological age from neuroimaging have found accelerated brain aging in obesity, but it is unclear…
View article: Author response: The effect of weight loss following 18 months of lifestyle intervention on brain age assessed with resting-state functional connectivity
Author response: The effect of weight loss following 18 months of lifestyle intervention on brain age assessed with resting-state functional connectivity Open
Full text Figures and data Side by side Abstract Editor's evaluation eLife digest Introduction Methods Results Discussion Data availability References Decision letter Author response Article and author information Metrics Abstract Backgrou…
View article: Microbiome-metabolome interactions predict host phenotype
Microbiome-metabolome interactions predict host phenotype Open
The effect of microbes on their human host is often mediated through changes in metabolite concentrations. As such, multiple tools have been proposed to predict metabolitc profiles from microbial taxa frequencies, assuming a direct relatio…
View article: The effect of 18 months lifestyle intervention on brain age assessed with resting-state functional connectivity
The effect of 18 months lifestyle intervention on brain age assessed with resting-state functional connectivity Open
Obesity negatively impacts multiple bodily systems, including the central nervous system. Retrospective studies that estimated chronological age from neuroimaging have found accelerated brain aging in obesity, but it is unclear how this es…
View article: Changes in Circulating miR-375-3p and Improvements in Visceral and Hepatic Fat Contents in Response to Lifestyle Interventions: The CENTRAL Trial
Changes in Circulating miR-375-3p and Improvements in Visceral and Hepatic Fat Contents in Response to Lifestyle Interventions: The CENTRAL Trial Open
Objective: To investigate whether changes in circulating levels of pancreatic islet-related microRNA-375 (miR-375) were related to improved visceral and intrahepatic fat accumulation. Research Design and Methods: This study included adu…
View article: Changes in Circulating miR-375-3p and Improvements in Visceral and Hepatic Fat Contents in Response to Lifestyle Interventions: The CENTRAL Trial
Changes in Circulating miR-375-3p and Improvements in Visceral and Hepatic Fat Contents in Response to Lifestyle Interventions: The CENTRAL Trial Open
Objective: To investigate whether changes in circulating levels of pancreatic islet-related microRNA-375 (miR-375) were related to improved visceral and intrahepatic fat accumulation. Research Design and Methods: This study included adu…
View article: Changes in Circulating miR-375-3p and Improvements in Visceral and Hepatic Fat Contents in Response to Lifestyle Interventions: The CENTRAL Trial
Changes in Circulating miR-375-3p and Improvements in Visceral and Hepatic Fat Contents in Response to Lifestyle Interventions: The CENTRAL Trial Open
OBJECTIVE To investigate whether changes in circulating levels of pancreatic islet–related miRNA-375 (miR-375) are related to improved visceral and intrahepatic fat accumulation. RESEARCH DESIGN AND METHODS This study included adults with …