Iris Stoltenborg
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View article: Chemogenetic re-activation of a neuronal ensemble in the lateral hypothalamus that is active during activity-based anorexia in mice modulates feeding and running activity
Chemogenetic re-activation of a neuronal ensemble in the lateral hypothalamus that is active during activity-based anorexia in mice modulates feeding and running activity Open
A high level of physical activity is common in patients with anorexia nervosa and can exacerbate symptoms and recovery prognosis. The underlying cause is not known but is most likely regulated by the brain and may derive from energy defici…
View article: Intranasal Delivery of a Ghrelin Mimetic Engages the Brain Ghrelin Signaling System in Mice
Intranasal Delivery of a Ghrelin Mimetic Engages the Brain Ghrelin Signaling System in Mice Open
Ghrelin, the endogenous ligand of the growth hormone secretagogue receptor (GHSR), promotes food intake and other feeding behaviors, and stimulates growth hormone (GH) release from the pituitary. Growth hormone secretagogues (GHS), such as…
View article: Engagement of the brain orexin system in activity-based anorexia behaviour in mice
Engagement of the brain orexin system in activity-based anorexia behaviour in mice Open
While excessive physical activity is common amongst anorexia nervosa (AN) patients, contributing to their low body weight, little is known about the underlying biology and effective treatments targeting the hyperactivity are lacking. Given…
View article: TRAPing Ghrelin-Activated Circuits: A Novel Tool to Identify, Target and Control Hormone-Responsive Populations in TRAP2 Mice
TRAPing Ghrelin-Activated Circuits: A Novel Tool to Identify, Target and Control Hormone-Responsive Populations in TRAP2 Mice Open
The availability of Cre-based mouse lines for visualizing and targeting populations of hormone-sensitive cells has helped identify the neural circuitry driving hormone effects. However, these mice have limitations and may not even be avail…
The Orexigenic Force of Olfactory Palatable Food Cues in Rats Open
Environmental cues recalling palatable foods motivate eating beyond metabolic need, yet the timing of this response and whether it can develop towards a less palatable but readily available food remain elusive. Increasing evidence indicate…
View article: A skeleton in the cupboard in ghrelin research: Where are the skinny dwarfs?
A skeleton in the cupboard in ghrelin research: Where are the skinny dwarfs? Open
Based on studies delivering ghrelin or ghrelin receptor agonists, we have learned a great deal about the importance of the brain ghrelin signalling system for a wide range of physiological processes that include feeding behaviours, growth …
The orexigenic force of olfactory palatable food cues in sated rats Open
Background Environmental cues recalling palatable foods are ubiquitous and motivate eating beyond metabolic need, yet the timing of this response and whether it can develop towards a non-palatable readily available food remain elusive. Alt…
View article: Functional and Neurochemical Identification of Ghrelin Receptor (GHSR)-Expressing Cells of the Lateral Parabrachial Nucleus in Mice
Functional and Neurochemical Identification of Ghrelin Receptor (GHSR)-Expressing Cells of the Lateral Parabrachial Nucleus in Mice Open
The lateral parabrachial nucleus (lPBN), located in the pons, is a well-recognized anorexigenic center harboring, amongst others, the calcitonin gene-related peptide (CGRP)-expressing neurons that play a key role. The receptor for the orex…
Single-cell analysis reveals cellular heterogeneity and molecular determinants of hypothalamic leptin-receptor cells Open
Hypothalamic nuclei which regulate homeostatic functions express leptin receptor (LepR), the primary target of the satiety hormone leptin. Single-cell RNA sequencing (scRNA-seq) has facilitated the discovery of a variety of hypothalamic ce…
View article: Impact of Free‐Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety‐Like Behavior in Rats
Impact of Free‐Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety‐Like Behavior in Rats Open
Objective Rats were exposed to free‐choice diets (fat plus one of two different sugar solutions, glucose or sucrose), and the metabolic consequences and impact on locomotor activity and anxiety‐like behavior were explored. Methods For 3 we…