Iris Stolzer
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View article: Absence of Microglial Activation and Maintained Hippocampal Neurogenesis in a Transgenic Mouse Model of Crohn’s Disease
Absence of Microglial Activation and Maintained Hippocampal Neurogenesis in a Transgenic Mouse Model of Crohn’s Disease Open
Adult neurogenesis in the hippocampal dentate gyrus (DG) is not only essential for learning and pattern separation, but it is also involved in emotional regulation. This process is vulnerable to local and peripheral inflammation, which is …
View article: Integrated multimodel analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD
Integrated multimodel analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD Open
Background IBD is a chronic inflammatory condition driven by complex genetic and immune interactions, yet preclinical models often fail to fully recapitulate all aspects of the human disease. A systematic comparison of commonly used IBD mo…
View article: TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice
TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice Open
Intestinal immune homeostasis relies on intestinal epithelial cells (IECs), which provide an efficient barrier, and warrant a state of tolerance between the microbiome and the mucosal immune system. Thus, proper epithelial microbial sensin…
View article: Integrated multi-model analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD
Integrated multi-model analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD Open
Background Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the intestine with a complex and multifaceted pathogenesis. While various animal models exist to study specific disease mechanisms relevant to human IBD, a …
View article: Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery
Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery Open
Our results identify IEC necroptosis as a critical link between the gut and the development of arthritis.
View article: Neuroinflammatory disease signatures in SPG11-related hereditary spastic paraplegia patients
Neuroinflammatory disease signatures in SPG11-related hereditary spastic paraplegia patients Open
Biallelic loss of SPG11 function constitutes the most frequent cause of complicated autosomal recessive hereditary spastic paraplegia (HSP) with thin corpus callosum, resulting in progressive multisystem neurodegeneration. While the impact…
View article: IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling
IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling Open
Objective We sought to investigate the role of interleukin (IL)-20 in IBD and experimental colitis. Design Experimental colitis was induced in mice deficient in components of the IL-20 and signal transducer and activator of transcription (…
View article: Impact of Microbiome–Brain Communication on Neuroinflammation and Neurodegeneration
Impact of Microbiome–Brain Communication on Neuroinflammation and Neurodegeneration Open
The gut microbiome plays a pivotal role in maintaining human health, with numerous studies demonstrating that alterations in microbial compositions can significantly affect the development and progression of various immune-mediated disease…
View article: Human α-Defensin 51–9 and Human β-Defensin 2 Improve Metabolic Parameters and Gut Barrier Function in Mice Fed a Western-Style Diet
Human α-Defensin 51–9 and Human β-Defensin 2 Improve Metabolic Parameters and Gut Barrier Function in Mice Fed a Western-Style Diet Open
Obesity and metabolic comorbidities are associated with gut permeability. While high-fructose and Western-style diet (WSD) disrupt intestinal barrier function, oral administration of human α-defensin 5 (HD5) and β-defensin 2 (hBD2) is beli…
View article: Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing
Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing Open
The paracaspase MALT1 is a crucial regulator of immune responses in various cellular contexts. Recently, there is increasing evidence suggesting that MALT1 might represent a novel key player in mucosal inflammation. However, the molecular …
View article: Vitamin A- and D-Deficient Diets Disrupt Intestinal Antimicrobial Peptide Defense Involving Wnt and STAT5 Signaling Pathways in Mice
Vitamin A- and D-Deficient Diets Disrupt Intestinal Antimicrobial Peptide Defense Involving Wnt and STAT5 Signaling Pathways in Mice Open
Vitamin A and D deficiencies are associated with immune modulatory effects and intestinal barrier impairment. However, the underlying mechanisms remain unclear. C57BL/6J mice were fed either a diet lacking in vitamin A (VAd), vitamin D (VD…
View article: Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation
Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation Open
Objective Increased apoptotic shedding has been linked to intestinal barrier dysfunction and development of inflammatory bowel diseases (IBD). In contrast, physiological cell shedding allows the renewal of the epithelial monolayer without …
View article: Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe‐host‐communication in vivo
Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe‐host‐communication in vivo Open
The intestinal microbiota influences mammalian host physiology in health and disease locally in the gut but also in organs devoid of direct contact with bacteria such as the liver and brain. Extracellular vesicles (EVs) or outer membrane v…
View article: Prebiotic Inulin and Sodium Butyrate Attenuate Obesity-Induced Intestinal Barrier Dysfunction by Induction of Antimicrobial Peptides
Prebiotic Inulin and Sodium Butyrate Attenuate Obesity-Induced Intestinal Barrier Dysfunction by Induction of Antimicrobial Peptides Open
Defects in the mucosal barrier have been associated with metabolic diseases such as obesity and non-alcoholic fatty liver disease (NAFLD). Mice fed a Western-style diet (WSD) develop obesity and are characterized by a diet-induced intestin…
View article: An IFN-STAT Axis Augments Tissue Damage and Inflammation in a Mouse Model of Crohn's Disease
An IFN-STAT Axis Augments Tissue Damage and Inflammation in a Mouse Model of Crohn's Disease Open
Blocking interferon-function by therapeutic intervention of the JAK-STAT-axis is a novel promising treatment option for inflammatory bowel disease (IBD). Although JAK inhibitors have proven efficacy in patients with active ulcerative colit…
View article: Interferons at the crossroad of cell death pathways during gastrointestinal inflammation and infection
Interferons at the crossroad of cell death pathways during gastrointestinal inflammation and infection Open
Interferons (IFNs) are pleiotropic immune-modulatory cytokines that are well known for their essential role in host defense against viruses, bacteria, and other pathogenic microorganisms. They can exert both, protective or destructive func…
View article: Matricellular Protein SPARCL1 Regulates Blood Vessel Integrity and Antagonizes Inflammatory Bowel Disease
Matricellular Protein SPARCL1 Regulates Blood Vessel Integrity and Antagonizes Inflammatory Bowel Disease Open
Background The understanding of vascular plasticity is key to defining the role of blood vessels in physiologic and pathogenic processes. In the present study, the impact of the vascular quiescence marker SPARCL1 on angiogenesis, capillary…