Irit Miller
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View article: Fyn and argonaute 2 participate in maternal-mRNA degradation during mouse oocyte maturation
Fyn and argonaute 2 participate in maternal-mRNA degradation during mouse oocyte maturation Open
Fertilization triggers physiological degradation of maternal-mRNAs, which are then replaced by embryonic transcripts. Ample evidence suggests that Argonaut 2 (AGO2) is a possible post-fertilization regulator of maternal-mRNAs degradation; …
View article: Cancer During Pregnancy: The Role of Vascular Toxicity in Chemotherapy-Induced Placental Toxicity
Cancer During Pregnancy: The Role of Vascular Toxicity in Chemotherapy-Induced Placental Toxicity Open
Breast cancer is diagnosed in ~0.3% of pregnant women. Studies that have addressed gestational and neonatal outcomes of chemotherapy during pregnancy have demonstrated increased gestational complications including preeclampsia and intraute…
View article: Pigment epithelium-derived factor (PEDF) negates hyperandrogenic PCOS features
Pigment epithelium-derived factor (PEDF) negates hyperandrogenic PCOS features Open
Polycystic ovary syndrome (PCOS), one of the most common female endocrine disorder, is a prevalent cause of infertility. Hyperandrogenism is a key feature in PCOS and is correlated with increased expression of VEGF and cytokines in the ova…
View article: Pre-ovulatory intercellular regulation of miR-125a-3p within mouse ovarian follicles
Pre-ovulatory intercellular regulation of miR-125a-3p within mouse ovarian follicles Open
miR-125a-3p, a post-transcription regulator of Fyn kinase, is expressed in mouse pre-ovulatory follicles; its expression within the follicle decreases toward ovulation. Our aim was to follow the synthesis of miR-125a-3p and regulation of i…
View article: Elucidating the role of pigment epithelium-derived factor (PEDF) in metabolic PCOS models
Elucidating the role of pigment epithelium-derived factor (PEDF) in metabolic PCOS models Open
PCOS is the most common endocrinopathy in women; associated with obesity and insulin resistance (IR). IR leads to accumulation of advanced-glycation-end-products (AGEs) and their receptor, RAGE. PCOS patients have increased levels of vascu…
View article: The Dual Role of PEDF in the Pathogenesis of OHSS: Negating Both Angiogenic and Inflammatory Pathways
The Dual Role of PEDF in the Pathogenesis of OHSS: Negating Both Angiogenic and Inflammatory Pathways Open
Our findings provide a framework that correlates down-regulation of OHSS symptoms caused by PEDF with both angiogenic and inflammatory pathways.
View article: GnRH Agonist Triggering Modulates PEDF to VEGF Ratio Inversely to hCG in Granulosa Cells
GnRH Agonist Triggering Modulates PEDF to VEGF Ratio Inversely to hCG in Granulosa Cells Open
GnRH-a triggering induces a direct effect on PEDF/VEGF balance in granulosa cells inversely to hCG. Our results suggest a novel elucidation to the GnRH-a triggering-mediated risk reduction of OHSS and may clarify the pros and cons of this …
View article: Gonadotrophin-releasing hormone agonists for fertility preservation: unraveling the enigma?
Gonadotrophin-releasing hormone agonists for fertility preservation: unraveling the enigma? Open
This work was partially supported by a grant from the Israel Science Foundation (ISF) to I.B.-A. The authors have no conflict of interest to disclose.