Irma Fredriksson
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View article: Variation in Pathological Appearance Across Repeated Sampling from Probably Benign Breast Lesions
Variation in Pathological Appearance Across Repeated Sampling from Probably Benign Breast Lesions Open
Background: The diagnostic process for probable benign breast lesions involves a 1–40% upgrade rate to malignancy when biopsy (cytology and/or histology) is compared with surgery. In a previously conducted clinical randomized trial, we aim…
View article: Obstetric and perinatal outcomes following a diagnosis of gynecologic cancer during pregnancy
Obstetric and perinatal outcomes following a diagnosis of gynecologic cancer during pregnancy Open
Gynecologic cancer during pregnancy was associated with higher risks of preterm birth and adverse preterm-related outcomes. The risks of maternal pregnancy complications and low birth weight for gestational age were similar to those of can…
View article: Major systemic infection following breast cancer surgery and oncological outcomes
Major systemic infection following breast cancer surgery and oncological outcomes Open
Background Postoperative infections are well-known complications following cancer surgery and are associated with worse oncological outcomes in several cancer types. The influence of major systemic postoperative infections on the risk of b…
View article: Benchmarking cancer outcomes in Europe: a scoping review of methodologies and case-mix adjustments
Benchmarking cancer outcomes in Europe: a scoping review of methodologies and case-mix adjustments Open
Background: Benchmarking hospital outcomes is crucial for identifying inequities and improving cancer care. Meaningful comparisons require selecting relevant outcomes and adjusting for case-mix factors such as age, comorbidity, and stage. …
View article: Breaking down the costs for breast cancer: Insights from Sweden’s National Quality Register
Breaking down the costs for breast cancer: Insights from Sweden’s National Quality Register Open
Background With emerging new technologies for diagnostics and treatment for breast cancer, there is a demand for updated breast cancer costs based on current clinical practice. The objectives of the current study were to (a) estimate recen…
View article: Patient experience and healthcare cost aspects of vacuum-assisted excision of breast lesions. A report from the Swedish VAE randomized clinical trial
Patient experience and healthcare cost aspects of vacuum-assisted excision of breast lesions. A report from the Swedish VAE randomized clinical trial Open
The VAE procedure using a 7G needle size was well -accepted by patients and conferred no increase in complications, including pain, compared to a 10G needle size. The VAE procedure had superior cost-efficiency compared to OSE.
View article: Postoperative complications after breast cancer surgery and effect on recurrence and survival: population-based cohort study
Postoperative complications after breast cancer surgery and effect on recurrence and survival: population-based cohort study Open
Background There is conflicting evidence regarding whether postoperative complications after breast cancer surgery are associated with worse oncological outcome. This study aimed to assess the risk of systemic breast cancer recurrence afte…
View article: 72224 - Characteristics and management of locally advanced breast cancer – a retrospective register study from Breast Cancer DataBase Sweden (BCBaSe) 3.0
72224 - Characteristics and management of locally advanced breast cancer – a retrospective register study from Breast Cancer DataBase Sweden (BCBaSe) 3.0 Open
Introduction Locally advanced breast cancer (LABC) refers to large primary breast tumours (T3), tumours of any size with chest wall/skin involvement (T4), and/or extensive lymph node involvement (N2-3). LABC may be a consequence of delayed…
View article: 72309 - Postoperative complications after breast cancer surgery and effect on recurrence and survival – a large population-based cohort study
72309 - Postoperative complications after breast cancer surgery and effect on recurrence and survival – a large population-based cohort study Open
Introduction This study aimed to assess the risk of systemic breast cancer recurrence after surgical site infection (SSI) and also the impact of SSI on locoregional recurrence, overall survival (OS), and breast cancer-specific survival (BC…
View article: AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial
AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial Open
Screening mammography reduces breast cancer mortality, but studies analyzing interval cancers diagnosed after negative screens have shown that many cancers are missed. Supplemental screening using magnetic resonance imaging (MRI) can reduc…
View article: Worse histopathology and prognosis in women with breast cancer diagnosed during the second trimester of pregnancy
Worse histopathology and prognosis in women with breast cancer diagnosed during the second trimester of pregnancy Open
Women diagnosed during pregnancy or within the first year after delivery have a worse prognosis than women diagnosed not near pregnancy due to adverse tumour biology and advanced stage at diagnosis. A worse prognosis for women diagnosed du…
View article: Real-world overall survival and characteristics of patients with ER-zero and ER-low HER2-negative breast cancer treated as triple-negative breast cancer: a Swedish population-based cohort study
Real-world overall survival and characteristics of patients with ER-zero and ER-low HER2-negative breast cancer treated as triple-negative breast cancer: a Swedish population-based cohort study Open
This work was financially supported by Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA, in accordance with terms and conditions of a Master Collaboration Agreement between the company and Karolinska Institutet.
View article: Prognostic impact of HER2 biomarker levels in trastuzumab-treated early HER2-positive breast cancer
Prognostic impact of HER2 biomarker levels in trastuzumab-treated early HER2-positive breast cancer Open
Background Overexpression of human epidermal growth factor receptor 2 (HER2) caused by HER2 gene amplification is a driver in breast cancer tumorigenesis. We aimed to investigate the prognostic significance of manual scoring and digital im…
View article: Immune cell infiltrate in ductal carcinoma <i>in situ</i> and the risk of dying from breast cancer: case–control study
Immune cell infiltrate in ductal carcinoma <i>in situ</i> and the risk of dying from breast cancer: case–control study Open
Background Studies identifying risk factors for death from breast cancer after ductal carcinoma in situ (DCIS) are rare. In this retrospective nested case–control study, clinicopathological factors in women treated for DCIS and who died fr…
View article: Obstetric and perinatal outcomes in women with previous breast cancer: a nationwide study of singleton births 1973–2017
Obstetric and perinatal outcomes in women with previous breast cancer: a nationwide study of singleton births 1973–2017 Open
STUDY QUESTION What are the obstetric and perinatal outcomes in births to breast cancer survivors compared to women without previous breast cancer? SUMMARY ANSWER Women who conceived during the first 2 years following a breast cancer diagn…
View article: Impact of Primary Breast Surgery on Overall Survival of Patients With De Novo Metastatic Breast Cancer: A Systematic Review and Meta-Analysis
Impact of Primary Breast Surgery on Overall Survival of Patients With De Novo Metastatic Breast Cancer: A Systematic Review and Meta-Analysis Open
Background Breast surgery in cases of de novo metastatic breast cancer (MBC) is associated with improved outcomes in retrospective studies, although the results of randomized controlled trials (RCTs) are conflicting. We aimed to investigat…
View article: Risk factors for the increasing incidence of pregnancy‐associated cancer in Sweden – a population‐based study
Risk factors for the increasing incidence of pregnancy‐associated cancer in Sweden – a population‐based study Open
Introduction The incidence of cancer during pregnancy and within first year post‐delivery, ie pregnancy‐associated cancer (PAC), is increasing in many countries, but little is known about risk factors for these trends. This study quantifie…
View article: De novo metastatic breast cancer in men vs women: a Swedish population-based cohort study
De novo metastatic breast cancer in men vs women: a Swedish population-based cohort study Open
Current evidence on de novo metastatic breast cancer is based on data from women. This Swedish population-based cohort study compared the incidence over time and prognosis of de novo metastatic breast cancer between sexes using data from t…
View article: Risk of obstetric and perinatal complications in women presenting with breast cancer during pregnancy and the first year postpartum in Sweden 1973–2017: A population‐based matched study
Risk of obstetric and perinatal complications in women presenting with breast cancer during pregnancy and the first year postpartum in Sweden 1973–2017: A population‐based matched study Open
Introduction For women presenting with breast cancer during pregnancy, treatment guidelines were historically restricted to only surgical treatment. Over the past decades, chemotherapy administered during pregnancy has been gradually intro…
View article: OptiBra study, a randomized controlled trial on optimal postoperative bra support after breast cancer surgery
OptiBra study, a randomized controlled trial on optimal postoperative bra support after breast cancer surgery Open
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