Irmengard Sax
YOU?
Author Swipe
View article: P07.16.B A NOVEL METHOD ENABLING THE DETECTION OF INTRACELLULAR DRUGS BY SEQUENCING ON SINGLE-CELL LEVEL IN GLIOBLASTOMA
P07.16.B A NOVEL METHOD ENABLING THE DETECTION OF INTRACELLULAR DRUGS BY SEQUENCING ON SINGLE-CELL LEVEL IN GLIOBLASTOMA Open
BACKGROUND Glioblastoma is an aggressive and incurable primary brain tumor, primarily due to its resistance to standard therapies and imminent recurrence. The increasing importance of Single-Cell RNA Sequencing (scRNA-Seq) in deciphering t…
View article: Dissecting Tumor Heterogeneity by Liquid Biopsy—A Comparative Analysis of Post-Mortem Tissue and Pre-Mortem Liquid Biopsies in Solid Neoplasias
Dissecting Tumor Heterogeneity by Liquid Biopsy—A Comparative Analysis of Post-Mortem Tissue and Pre-Mortem Liquid Biopsies in Solid Neoplasias Open
Tumor heterogeneity encompasses genetic, epigenetic, and phenotypic diversity, impacting treatment response and resistance. Spatial heterogeneity occurs both inter- and intra-lesionally, while temporal heterogeneity results from clonal evo…
View article: Double heterozygous pathogenic variants in BRCA2 and CHEK2 in a girl with adrenocortical carcinoma
Double heterozygous pathogenic variants in BRCA2 and CHEK2 in a girl with adrenocortical carcinoma Open
Pediatric adrenocortical tumors (pACTs) are rare endocrine neoplasms with variable prognosis, commonly associated with germline pathogenic variants (PVs) in the tumor suppressor gene TP53. Here, we report the case of a 3.1-year-old female …
View article: Concept and feasibility of the Augsburg Longitudinal Plasma Study (ALPS) – a prospective trial for comprehensive liquid biopsy-based longitudinal monitoring of solid cancer patients
Concept and feasibility of the Augsburg Longitudinal Plasma Study (ALPS) – a prospective trial for comprehensive liquid biopsy-based longitudinal monitoring of solid cancer patients Open
Objectives Liquid biopsy (LBx) provides diagnostic, prognostic and predictive insights for malignant diseases and offers promising applications regarding tumor burden, tumor heterogeneity and clonal evolution. Methods The Augsburg Longitud…