Imran Iqbal
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View article: Microbial metabolites from gut bacteria as novel anti-cancer agents
Microbial metabolites from gut bacteria as novel anti-cancer agents Open
Recent evidence highlights the potential of gut microbial metabolites as promising anticancer agents, with mechanisms distinct from those of conventional chemotherapeutics. Short-chain fatty acids, particularly butyrate, exhibit histone de…
View article: CRISPR-Cas13a diagnostics for circulating microbial transcripts in pancreatic cancer
CRISPR-Cas13a diagnostics for circulating microbial transcripts in pancreatic cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is the seventh leading cause of global cancer deaths, with a 5-year survival rate below 11% and over 80% of cases diagnosed at advanced, unresectable stages. Current biomarkers such as CA19-9 show su…
View article: Intratumoral microbiota as prognostic biomarkers in gastrointestinal cancers
Intratumoral microbiota as prognostic biomarkers in gastrointestinal cancers Open
Recent evidence highlights that the tumor microenvironment in gastrointestinal (GI) cancers harbors distinct microbial communities with potential prognostic value. GI malignancies account for nearly 25% of all cancer-related deaths worldwi…
View article: Prevalence of Electrolyte Imbalances in Critically Ill Medical Intensive Care Unit Patients and Their Association With Clinical Outcomes
Prevalence of Electrolyte Imbalances in Critically Ill Medical Intensive Care Unit Patients and Their Association With Clinical Outcomes Open
Background Electrolyte disturbances are frequent in critically ill patients and may contribute to poor outcomes. Despite routine monitoring in intensive care units (ICUs), their prevalence and impact on prognosis among medical ICU populati…
View article: Incidence of Fungal Pneumonia in Children with Acute Myeloid Leukemia Taking Oral Antifungal Prophylaxis
Incidence of Fungal Pneumonia in Children with Acute Myeloid Leukemia Taking Oral Antifungal Prophylaxis Open
Acute leukemia is common in children, with acute lymphoblastic leukemia (ALL) making up 80-85% and acute myeloid leukemia (AML) 10-15%. Objective: To determine the incidence of fungal pneumonia in children with acute myeloid leukemia takin…
View article: Myocardial Fibrosis in Hypertensive Heart Disease: Correlation with Serum Biomarkers and Perioperative Cardiovascular Outcome
Myocardial Fibrosis in Hypertensive Heart Disease: Correlation with Serum Biomarkers and Perioperative Cardiovascular Outcome Open
Myocardial fibrosis is a common but underdiagnosed complication of hypertensive heart disease (HHD). It contributes significantly to adverse perioperative cardiovascular outcomes. Cardiac MRI remains the gold standard for detection; howeve…
View article: Assessing Large Language Model Utility and Limitations in Diabetes Education: A Cross-Sectional Study of Patient Interactions and Specialist Evaluations
Assessing Large Language Model Utility and Limitations in Diabetes Education: A Cross-Sectional Study of Patient Interactions and Specialist Evaluations Open
Objectives To assess the value of an AI-powered conversational agent in supporting diabetes self-management among adults with diabetic retinopathy and limited educational backgrounds. Methods In this cross-sectional study, 51 adults with T…
View article: Effectiveness of Structured Diabetes Education Programs in Improving HbA1c and Treatment Adherence Among Newly Diagnosed Patients in Pakistan
Effectiveness of Structured Diabetes Education Programs in Improving HbA1c and Treatment Adherence Among Newly Diagnosed Patients in Pakistan Open
Diabetes mellitus is a major public health challenge in Pakistan, with poor glycemic control and suboptimal treatment adherence contributing to high morbidity. Structured diabetes self-management education (DSME) programs have demonstrated…
View article: ATRIAL FIBRILATION FOLLOWING MITRAL VALVE REPLACEMENT FOR MITRAL STENOSIS: A CROSS-SECTIONAL STUDY
ATRIAL FIBRILATION FOLLOWING MITRAL VALVE REPLACEMENT FOR MITRAL STENOSIS: A CROSS-SECTIONAL STUDY Open
Background: Atrial fibrillation (AF) is a frequent and serious postoperative complication in patients undergoing mitral valve replacement (MVR), especially in those with underlying mitral stenosis (MS). Postoperative AF increases the risk …
View article: Diagnosis of Albright Hereditary Osteodystrophy (AHO) in a 20 Years Female: A Case Report
Diagnosis of Albright Hereditary Osteodystrophy (AHO) in a 20 Years Female: A Case Report Open
Albright hereditary osteodystrophy (AHO) is a rare metabolic, autosomal dominant syndrome that may or may not be associated with parathormone deficiency (pseudohypoparathyroidism). It is a rare genetic autosomal dominant maternally transmi…
View article: EFFECTIVENESS OF TOTAL LEUKOCYTE COUNT (TLC) AND C-REACTIVE PROTEIN (CRP) IN THE DIAGNOSIS OF ACUTE APPENDICITIS
EFFECTIVENESS OF TOTAL LEUKOCYTE COUNT (TLC) AND C-REACTIVE PROTEIN (CRP) IN THE DIAGNOSIS OF ACUTE APPENDICITIS Open
Acute appendicitis is a typical surgical emergency. Diagnosing it can be challenging due to variable symptoms. Total leukocyte count (TLC) and C-reactive protein (CRP) are commonly used to assess inflammation and guide treatment. This stud…
View article: In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset
In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset Open
Children with a pulse oximetry measurement had a lower CFR. Many children hospitalized with chest-indrawing pneumonia were hypoxemic and one in 10 died. Young age and moderate malnutrition were risk factors for in-hospital chest-indrawing …
View article: Assembling a global database of child pneumonia studies to inform WHO pneumonia management algorithm: Methodology and applications
Assembling a global database of child pneumonia studies to inform WHO pneumonia management algorithm: Methodology and applications Open
This data set could identify an improved specific, sensitive set of criteria for diagnosing clinical pneumonia and help identify sick children in need of referral to a higher level of care or a change of therapy. Field studies could be des…
View article: Derivation and validation of a novel risk assessment tool to identify children aged 2–59 months at risk of hospitalised pneumonia-related mortality in 20 countries
Derivation and validation of a novel risk assessment tool to identify children aged 2–59 months at risk of hospitalised pneumonia-related mortality in 20 countries Open
Introduction Existing risk assessment tools to identify children at risk of hospitalised pneumonia-related mortality have shown suboptimal discriminatory value during external validation. Our objective was to derive and validate a novel ri…
View article: Clinical prediction system of complications among patients with COVID-19: A development and validation retrospective multicentre study during first wave of the pandemic
Clinical prediction system of complications among patients with COVID-19: A development and validation retrospective multicentre study during first wave of the pandemic Open
Clinical evidence suggests that some patients diagnosed with coronavirus disease 2019 (COVID-19) experience a variety of complications associated with significant morbidity, especially in severe cases during the initial spread of the pande…
View article: Glycemic status of infants of diabetic mothers; a study at the Children’s Hospital and Institute of Child Health, Multan.
Glycemic status of infants of diabetic mothers; a study at the Children’s Hospital and Institute of Child Health, Multan. Open
Objective: To find out the frequency of hypoglycemia among infants of diabetic mothers (IDMs) and factors affecting it. Study Design: Descriptive Cross Sectional study. Setting: Department of Neonatology, The Children’s Hospital and Instit…
View article: External validation of the RISC, RISC-Malawi, and PERCH clinical prediction rules to identify risk of death in children hospitalized with pneumonia
External validation of the RISC, RISC-Malawi, and PERCH clinical prediction rules to identify risk of death in children hospitalized with pneumonia Open
In a large external application of the RISC, RISC-Malawi, and PERCH scores, a substantial number of children were misclassified for their risk of hospitalized pneumonia-related mortality. Although pneumonia risk scores have performed well …
View article: A clinical risk score to predict in-hospital mortality in critically ill patients with COVID-19: a retrospective cohort study
A clinical risk score to predict in-hospital mortality in critically ill patients with COVID-19: a retrospective cohort study Open
Objectives To identify factors influencing the mortality risk in critically ill patients with COVID-19, and to develop a risk prediction score to be used at admission to intensive care unit (ICU). Design A multicentre cohort study. Setting…
View article: Early nasal continuous positive airway pressure in preterm neonates with Respiratory Distress Syndrome.
Early nasal continuous positive airway pressure in preterm neonates with Respiratory Distress Syndrome. Open
Objective: To assess the effectiveness of early nasal Continuous Positive Airway Pressure (nCPAP) in preterm neonates with respiratory distress syndrome (RDS). Study Design: Cohort study. Setting: Department of Neonatology, The Children’s …
View article: Clinical prediction system of complications among COVID-19 patients: a development and validation retrospective multicentre study
Clinical prediction system of complications among COVID-19 patients: a development and validation retrospective multicentre study Open
Existing prognostic tools mainly focus on predicting the risk of mortality among patients with coronavirus disease 2019. However, clinical evidence suggests that COVID-19 can result in non-mortal complications that affect patient prognosis…
View article: Thyroid function disorders in low birth weight/preterm neonates admitted in NICU, Children Hospital Complex Multan.
Thyroid function disorders in low birth weight/preterm neonates admitted in NICU, Children Hospital Complex Multan. Open
Objectives: Congenital hypothyroidism (CHT) is one of the major endocrine and metabolic disorders in neonates. Delayed diagnosis and treatment of CHT may lead to certain neuro-developmental disorders. Study Design: Prospective study. Setti…
View article: Five years study of mortality and morbidity patterns of Tetanus cases in a Tertiary Care PICU (Pediatric Intensive Care Unit), Multan Pakistan.
Five years study of mortality and morbidity patterns of Tetanus cases in a Tertiary Care PICU (Pediatric Intensive Care Unit), Multan Pakistan. Open
Objectives: Tetanus is an avoidable disease. Significant reduction in the incidence of tetanus is observed around the globe but in Pakistan, its incidence is still high. The objective of current study was to determine the demographic, clin…
View article: Neonatal-sepsis causative microorganisms and antimicrobial sensitivity in NICU, Children Hospital and Institute of Child Health, Multan.
Neonatal-sepsis causative microorganisms and antimicrobial sensitivity in NICU, Children Hospital and Institute of Child Health, Multan. Open
Objectives: The objective of this study was to identify the microorganisms and antimicrobial susceptibility pattern of neonatal septicemia in NICU, Children Hospital and Institute of Child Health, Multan. Study Design: Descriptive study. S…
View article: Clinical Efficacy and Safety of Injectable Levetiracetam Versus Phenytoin as Second-Line Therapy in the Management of Generalized Convulsive Status Epilepticus in Children: An Open-Label Randomized Controlled Trial
Clinical Efficacy and Safety of Injectable Levetiracetam Versus Phenytoin as Second-Line Therapy in the Management of Generalized Convulsive Status Epilepticus in Children: An Open-Label Randomized Controlled Trial Open
Levetiracetam is significantly more effective than phenytoin for the treatment of convulsive status epilepticus in children who have failed to respond to benzodiazepines.
View article: HEPATITIS–B VIRUS INFECTION;
HEPATITIS–B VIRUS INFECTION; Open
Objective: To describe the clinical presentations of hepatitis B virus infectionin children. Methodology: Children presenting with symptoms of liver diseases and otherdiseases who were found to be HBsAg positive by screening or ELISA metho…
View article: DIAMETER OF NORMAL CORONARY ARTERIES IN ADULT PAKISTANIS
DIAMETER OF NORMAL CORONARY ARTERIES IN ADULT PAKISTANIS Open
Objective: To determine the diameters of normal coronary arteries in a group ofadult Pakistanis and to compare the results with the data mentioned in literature. Methodology: Cross-sectional study conducted at Department of Cardiology,…
View article: EVALUATION RISK FACTORS OF NECROTIZING ENTEROCOLITIS
EVALUATION RISK FACTORS OF NECROTIZING ENTEROCOLITIS Open
Introduction: Necrotizing enterocolitis (NEC) is a condition where the intestinesbecome infected and can begin to die. Necrotizing enterocolitis is a serious condition that mayrequire surgery, and has a high morbidity and mortality rate. O…
View article: EVALUATION RISK FACTORS OF NECROTIZING ENTEROCOLITIS
EVALUATION RISK FACTORS OF NECROTIZING ENTEROCOLITIS Open
Introduction: Necrotizing enterocolitis (NEC) is a condition where the intestinesbecome infected and can begin to die. Necrotizing enterocolitis is a serious condition that mayrequire surgery, and has a high morbidity and mortality rate. O…
View article: FULL TERM BABIES;
FULL TERM BABIES; Open
Introduction: Perinatal asphyxia is one of the most common causes of neonatalmorbidity and mortality in most countries of the world. The objective of my study was to assessthe correlation of clinical findings of perinatal asphyxia with cra…