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View article: Evaluation of the Activity of Amino Chalcone Against Staphylococcus Strains Harboring Efflux Pumps
Evaluation of the Activity of Amino Chalcone Against Staphylococcus Strains Harboring Efflux Pumps Open
Background/Objectives: The increasing prevalence of multidrug-resistant Staphylococcus aureus represents a major clinical challenge, primarily driven by the acquisition of multiple resistance mechanisms. Among these, efflux pumps such as N…
View article: Evaluation of the Activity of Amino Chalcone Against <em>Staphylococcus</em> Strains Harboring Efflux Pumps
Evaluation of the Activity of Amino Chalcone Against <em>Staphylococcus</em> Strains Harboring Efflux Pumps Open
The emergence of efflux-mediated resistance in Staphylococcus aureus has limited the effectiveness of conventional antibiotics, highlighting the need for novel adjuvant compounds. This study investigated the synthetic chalcone CMA4DMA as a…
View article: Mechanisms of Action Involved in the In Vivo Gastroprotective Response of Fruits: A Systematic Review
Mechanisms of Action Involved in the In Vivo Gastroprotective Response of Fruits: A Systematic Review Open
Gastrointestinal diseases remain a significant global health concern, primarily due to the limitations of current pharmacological treatments, which often come with adverse side effects and high recurrence rates. This situation highlights t…
View article: Botany, Ethnomedicinal Uses, Biological Activities, Phytochemistry, and Technological Applications of Morinda citrifolia Plants
Botany, Ethnomedicinal Uses, Biological Activities, Phytochemistry, and Technological Applications of Morinda citrifolia Plants Open
Morinda citrifolia L., known as noni, is a tropical plant belonging to the Rubiaceae family and is widely used in traditional medicine for its therapeutic properties. This review compiles botanical, ethnomedicinal, phytochemical, and pharm…
View article: Anti‐Inflammatory and Anti‐Hyperalgesic Effects of <i>Ximenia americana</i> Bark Extract in a Murine Model of Rheumatoid Arthritis
Anti‐Inflammatory and Anti‐Hyperalgesic Effects of <i>Ximenia americana</i> Bark Extract in a Murine Model of Rheumatoid Arthritis Open
The aim of this study was to evaluate the anti‐hyperalgesic and anti‐inflammatory profiles of the hydroethanolic extract of Ximenia americana bark (HEXA) in a murine model of rheumatoid arthritis (RA). The RA model was induced through intr…
View article: Avaliação dos efeitos adversos associados ao uso indiscriminado de esteroides anabólicos androgênicos: revisão sistemática com meta-agregação
Avaliação dos efeitos adversos associados ao uso indiscriminado de esteroides anabólicos androgênicos: revisão sistemática com meta-agregação Open
Os esteroides anabólicos androgênicos (EAA) destacam-se por melhorar tanto o desempenho quanto a aparência física. No entanto, o uso indiscriminado de EAA frequentemente resulta em uma ampla gama de efeitos adversos, tanto a curto quanto a…
View article: Study of the Antioxidant and Antibacterial Effects of Genipa americana L. Against Food Pathogens
Study of the Antioxidant and Antibacterial Effects of Genipa americana L. Against Food Pathogens Open
This study presents the chemical profile of the ethanolic extract of Genipa americana L. stem bark and the evaluation of its antibacterial and antioxidant activities. The chemical prospecting consisted of a qualitative analysis and quantif…
View article: Evaluation of the Efflux Pump Inhibition Activity of Thiadiazine-Derived Compounds Against the Staphylococcus aureus 1199B Strain
Evaluation of the Efflux Pump Inhibition Activity of Thiadiazine-Derived Compounds Against the Staphylococcus aureus 1199B Strain Open
Background: Substances with antibacterial properties have become crucial in light of the continuous increase in infections caused by multidrug-resistant bacteria. In this context, thiadiazines have emerged as heterocyclic compounds already…
View article: ADME/Tox study and the effect of β-Caryophyllene on the resistant strain of Staphylococcus aureus carrying the QacA/B efflux pump gene
ADME/Tox study and the effect of β-Caryophyllene on the resistant strain of Staphylococcus aureus carrying the QacA/B efflux pump gene Open
View article: Evaluation of the Efflux Pump Inhibition Activity of Thiadiazine-Derived Compounds Against the <em>Staphylococcus aureus </em>1199B Strain
Evaluation of the Efflux Pump Inhibition Activity of Thiadiazine-Derived Compounds Against the <em>Staphylococcus aureus </em>1199B Strain Open
Substances with antibacterial properties have become crucial in light of the continuous increase in infections caused by multidrug-resistant bacteria. In this context, thiadiazines have emerged as heterocyclic compounds already known for t…
View article: Plinia peruviana (jaboticaba) extract inhibits the development of gastric ulcers in animal models through gastroprotective mechanisms
Plinia peruviana (jaboticaba) extract inhibits the development of gastric ulcers in animal models through gastroprotective mechanisms Open
View article: Antinociceptive Potential of Ximenia americana L. Bark Extract and Caffeic Acid: Insights into Pain Modulation Pathways
Antinociceptive Potential of Ximenia americana L. Bark Extract and Caffeic Acid: Insights into Pain Modulation Pathways Open
Background/Objectives: This study evaluated the antinociceptive effect of the Ximenia americana L. bark extract (HEXA) and its primary component, caffeic acid (CA), through in vivo assays. Methods: The antinociceptive properties were asses…
View article: Analysis of the Antibiotic-Potentiating Activity, Absorption, Distribution, Metabolism, and Excretion (ADME) and the Molecular Docking Properties of Phytol Against Multi-Drug-Resistant (MDR) Strains
Analysis of the Antibiotic-Potentiating Activity, Absorption, Distribution, Metabolism, and Excretion (ADME) and the Molecular Docking Properties of Phytol Against Multi-Drug-Resistant (MDR) Strains Open
Background: Phytol is a diterpene from the long-chain unsaturated acyclic alcohols, known for its diverse biological effects, including antimicrobial and anti-inflammatory activities. Present in essential oils, phytol is a promising candid…
View article: Antibacterial and Inhibitory Activity of Nora and Mepa Efflux Pumps of Estragole Complexed to β-Cyclodextrin (ES/β-CD) In Vitro Against Staphylococcus aureus Bacteria, Molecular Docking and MPO-Based Pharmacokinetics Prediction
Antibacterial and Inhibitory Activity of Nora and Mepa Efflux Pumps of Estragole Complexed to β-Cyclodextrin (ES/β-CD) In Vitro Against Staphylococcus aureus Bacteria, Molecular Docking and MPO-Based Pharmacokinetics Prediction Open
Background/Objectives: The work investigates the effect of the estragole complex encapsulated in beta-cyclodextrin (ES/β-CD) in modulating bacterial resistance, specifically in Staphylococcus aureus strains expressing NorA and MepA efflux …
View article: Co-Extraction of DNA and RNA from Candida albicans Using a Chemical Method in Conjunction with Silicon Carbide with Few Cells
Co-Extraction of DNA and RNA from Candida albicans Using a Chemical Method in Conjunction with Silicon Carbide with Few Cells Open
Objective: The study aimed to optimize protocols for the joint extraction of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) from 0.025 × 106 CFU of Candida albicans, targeting to overcome the challenges in the extraction of these g…
View article: Antiedematogenic and Anti‐Inflammatory Effects of the Essential Oil from the Fruits of <i>Piper tuberculatum</i> Jacq. (Piperaceae) in Animal Models
Antiedematogenic and Anti‐Inflammatory Effects of the Essential Oil from the Fruits of <i>Piper tuberculatum</i> Jacq. (Piperaceae) in Animal Models Open
Piper tuberculatum , traditionally known in Brazil as ‘pimenta‐d'arda,’ ‘pimenta‐longa,’ or ‘pimenta de macaco,’ has been used in Brazilian folk medicine to treat inflammatory symptoms. Considering this species’ significant essential oil c…
View article: Antinociceptive Potential of <em>Ximenia americana</em> L. Bark Extract and Caffeic Acid: Insights into Pain Modulation Pathways
Antinociceptive Potential of <em>Ximenia americana</em> L. Bark Extract and Caffeic Acid: Insights into Pain Modulation Pathways Open
Ximenia americana L. (Olacaceae) has traditionally been used in folk medicine in the African continent and Brazilian Northeast to treat diseases such as diarrhea, fever, wounds, and pain. This study evaluated the antinociceptive effect of …
View article: Evaluation of the Antifungal Activity of Eugenol against the <em>Candida albicans</em> Genomic DNA
Evaluation of the Antifungal Activity of Eugenol against the <em>Candida albicans</em> Genomic DNA Open
The objective of this study was to evaluate the antifungal activity of eugenol against the genomic DNA of Candida albicans. A quantitative experimental study was conducted with the C. albicans INCQS 40006 strain. Eugenol was tested in conc…
View article: Co-extraction of DNA and RNA from Candida albicans Using a Chemical Method in Conjunction with Silicon Carbide with Few Cells
Co-extraction of DNA and RNA from Candida albicans Using a Chemical Method in Conjunction with Silicon Carbide with Few Cells Open
The study aimed to optimize protocols for the joint extraction of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) from 0.025 x 106 CFU of Candida albicans, aiming to overcome challenges in the extraction of these genetic materials. …
View article: Thiazine-derived compounds in inhibiting efflux pump in Staphylococcus aureus K2068, mepA gene expression, and membrane permeability alteration
Thiazine-derived compounds in inhibiting efflux pump in Staphylococcus aureus K2068, mepA gene expression, and membrane permeability alteration Open
Staphylococcus aureus is a bacterium responsible for resistance to multiple drugs and the efflux system is widely studied among the resistance mechanisms developed by this species. The present study evaluates the inhibition of the MepA eff…
View article: Vasorelaxant effect of phenylpropanoids: Methyl eugenol and eugenol in human umbilical cord vein
Vasorelaxant effect of phenylpropanoids: Methyl eugenol and eugenol in human umbilical cord vein Open
Methyl-eugenol (ME) and eugenol (EUG) are phenylpropanoids with vasodilatory effects. While EUG's vasorelaxant effect in human umbilical artery (HUA) is known, their action in veins is unclear. This study aimed to evaluate ME and EUG in hu…
View article: Chemical analysis of Moringa oleifera (Moringaceae) seed oil and potentiation of antibiotic activity against standard and multidrug-resistant bacterial strains
Chemical analysis of Moringa oleifera (Moringaceae) seed oil and potentiation of antibiotic activity against standard and multidrug-resistant bacterial strains Open
Moringa oleifera (“moringa”) seeds are sources of fixed oil with a composition of fatty acids important for their biological properties. This work aimed to verify the fixed oil of seed, regarding chemical composition, antibacterial activit…
View article: Consensus of the medicinal use of Copaifera langsdorffii Desf. in different phytophysiognomies
Consensus of the medicinal use of Copaifera langsdorffii Desf. in different phytophysiognomies Open
The present study had as its objective to carry out an ethnobotanical survey of Copaíba in Cerradão, Carrasco, Wetland and Caatinga phytophysiognomies in the Chapada do Araripe, Northeast, Brazil, with a standardized form. Semi-structured …
View article: Assessment of Quercetin Antiemetic Properties: In Vivo and In Silico Investigations on Receptor Binding Affinity and Synergistic Effects
Assessment of Quercetin Antiemetic Properties: In Vivo and In Silico Investigations on Receptor Binding Affinity and Synergistic Effects Open
Quercetin (QUA), a flavonoid compound, is ubiquitously found in plants and has demonstrated a diverse range of biological activities. The primary objective of the current study is to assess the potential antiemetic properties of QUA using …
View article: Comparative Antibacterial and Efflux Pump Inhibitory Activity of Isolated Nerolidol, Farnesol, and α-Bisabolol Sesquiterpenes and Their Liposomal Nanoformulations
Comparative Antibacterial and Efflux Pump Inhibitory Activity of Isolated Nerolidol, Farnesol, and α-Bisabolol Sesquiterpenes and Their Liposomal Nanoformulations Open
The efflux systems are considered important mechanisms of bacterial resistance due to their ability to extrude various antibiotics. Several naturally occurring compounds, such as sesquiterpenes, have demonstrated antibacterial activity and…
View article: Assessment of Quercetin Antiemetic Properties: In Vivo and In Silico Investigations on Receptor Binding Affinity and Synergistic Effects
Assessment of Quercetin Antiemetic Properties: In Vivo and In Silico Investigations on Receptor Binding Affinity and Synergistic Effects Open
Quercetin (QUA), a flavonoid compound, is ubiquitously found in plants and has demonstrated a diverse range of biological activities. The primary objective of the present study is to assess the potential antiemetic properties of QUA using …
View article: Comparative antimicrobial potential of Ocimum basilicum essential oil, estragole and estragole/β-cyclodextrin complex in an infection model on adult zebrafish
Comparative antimicrobial potential of Ocimum basilicum essential oil, estragole and estragole/β-cyclodextrin complex in an infection model on adult zebrafish Open
Background: The need of the growth the production of more efficient medications for the control of bacterial infections has waked up the pharmaceutical industry to develop new drugs from compounds isolated from plants. Purpose: Therefore, …
View article: Enhancing the Antifungal Efficacy of Fluconazole with a Diterpene: Abietic Acid as a Promising Adjuvant to Combat Antifungal Resistance in Candida spp.
Enhancing the Antifungal Efficacy of Fluconazole with a Diterpene: Abietic Acid as a Promising Adjuvant to Combat Antifungal Resistance in Candida spp. Open
The increasing antifungal resistance rates against conventional drugs reveal the urgent need to search for new therapeutic alternatives. In this context, natural bioactive compounds have a critical role in antifungal drug development. Sinc…
View article: Biochemical aspects of the inflammatory process: A narrative review
Biochemical aspects of the inflammatory process: A narrative review Open
Inflammation is a protective response of the body potentially caused by microbial, viral, or fungal infections, tissue damage, or even autoimmune reactions. The cardinal signs of inflammation are consequences of immunological, biochemical,…
View article: Screening of the action mechanisms involved in the antinociceptive effect of isopulegol and its complex in cyclodextrin using acute nociception models in mice
Screening of the action mechanisms involved in the antinociceptive effect of isopulegol and its complex in cyclodextrin using acute nociception models in mice Open
Isopulegol, a terpene compound commonly present in the essential oils of several aromatic plants, may present a number of important pharmacological activities. Besides the screening of the antinociceptive effect of the monoterpene isopuleg…